Small Angle Scattering Biological Data Bank SASBDB

SASDSK9 – SAM riboswitch element A aptamer domain

SAM riboswitch element A aptamer domain (RNA) experimental SAS data

SAM riboswitch element A aptamer domain (RNA) Kratky plot

Sample:	SAM riboswitch element A aptamer domain (RNA) monomer, 39 kDa Listeria monocytogenes RNA
Buffer:	50 mM potassium phosphate, 135 mM NaCl, 5 mM MgCl2, pH: 6.5
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2022 Jun 9

Functional Validation of SAM Riboswitch Element A from Listeria monocytogenes. Biochemistry (2024)
Hall I, Zablock K, Sobetski R, Weidmann CA, Keane SC

R_g^Guinier	3.2	nm
D_max	11.7	nm
Volume^Porod	76	nm³

SASDSL9 – SAM riboswitch element A aptamer domain with bound S-adenosyl-L-methionine (SAM)

SAM riboswitch element A aptamer domain (RNA)S-adenosyl-L-methionine experimental SAS data

SAM riboswitch element A aptamer domain (RNA) S-adenosyl-L-methionine Kratky plot

Sample:	SAM riboswitch element A aptamer domain (RNA) monomer, 39 kDa Listeria monocytogenes RNA S-adenosyl-L-methionine monomer, 0 kDa
Buffer:	50 mM potassium phosphate, 135 mM NaCl, 5 mM MgCl2, pH: 6.5
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2022 Jun 9

Functional Validation of SAM Riboswitch Element A from Listeria monocytogenes. Biochemistry (2024)
Hall I, Zablock K, Sobetski R, Weidmann CA, Keane SC

R_g^Guinier	2.7	nm
D_max	10.2	nm
Volume^Porod	56	nm³

SASDNW9 – Glucose-regulated protein 78, nucleotide-binding domain

Endoplasmic reticulum chaperone BiP experimental SAS data

Sample:	Endoplasmic reticulum chaperone BiP monomer, 42 kDa Homo sapiens protein
Buffer:	phosphate buffered saline, pH: 7.2
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2021 Mar 21

Structural basis of CDNF interaction with the UPR regulator GRP78. Nat Commun 15(1):8175 (2024)
Graewert MA, Volkova M, Jonasson K, Määttä JAE, Gräwert T, Mamidi S, Kulesskaya N, Evenäs J, Johnsson RE, Svergun D, Bhattacharjee A, Huttunen HJ

R_g^Guinier	2.2	nm
D_max	6.5	nm
Volume^Porod	70	nm³

SASDNX9 – Glucose-regulated protein 78 nucleotide-binding domain (GRP78-NBD) in complex with Cerebral dopamine neurotrophic factor (CDNF)

Endoplasmic reticulum chaperone BiPCerebral dopamine neurotrophic factor experimental SAS data

Sample:	Endoplasmic reticulum chaperone BiP monomer, 42 kDa Homo sapiens protein Cerebral dopamine neurotrophic factor monomer, 21 kDa Homo sapiens protein
Buffer:	phosphate buffered saline, pH: 7.2
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2021 Mar 21

R_g^Guinier	2.8	nm
D_max	10.0	nm
Volume^Porod	75	nm³

SASDQS6 – Glucose-regulated protein 78 nucleotide-binding domain (GRP78-NBD) in complex with the C-terminal of Cerebral dopamine neurotrophic factor (C-CDNF)

Endoplasmic reticulum chaperone BiPC-terminal of the Cerebral dopamine neurotrophic factor experimental SAS data

Sample:	Endoplasmic reticulum chaperone BiP monomer, 42 kDa Homo sapiens protein C-terminal of the Cerebral dopamine neurotrophic factor monomer, 7 kDa Homo sapiens protein
Buffer:	phosphate buffered saline, pH: 7.2
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2021 Mar 23

R_g^Guinier	2.4	nm
D_max	6.9	nm
Volume^Porod	66	nm³

SASDUQ4 – Calcium/calmodulin-dependent protein kinase type II alpha (CaMKIIα) WT hub domain

Calcium/calmodulin-dependent protein kinase type II subunit alpha experimental SAS data

Sample:	Calcium/calmodulin-dependent protein kinase type II subunit alpha dodecamer, 186 kDa Homo sapiens protein
Buffer:	20 mM MES, 150 mM NaCl, 1 mM DTT, pH: 6
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2022 Oct 3

Ligand‐induced CaMKIIα hub Trp403 flip, hub domain stacking, and modulation of kinase activity Protein Science 33(10) (2024)
Narayanan D, Larsen A, Gauger S, Adafia R, Hammershøi R, Hamborg L, Bruus‐Jensen J, Griem‐Krey N, Gee C, Frølund B, Stratton M, Kuriyan J, Kastrup J, Langkilde A, Wellendorph P, Solbak S

R_g^Guinier	4.5	nm
D_max	15.2	nm
Volume^Porod	367	nm³

SASDUR4 – Calcium/calmodulin-dependent protein kinase type II alpha (CaMKIIα) WT hub domain

Sample:	Calcium/calmodulin-dependent protein kinase type II subunit alpha dodecamer, 186 kDa Homo sapiens protein
Buffer:	20 mM MES, 150 mM NaCl, 1 mM DTT, pH: 6
Experiment:	SAXS data collected at Xenocs BioXolver L with MetalJet, University of Copenhagen, Department of Drug Design and Pharmacology on 2020 Nov 19

R_g^Guinier	4.4	nm
D_max	14.9	nm
Volume^Porod	351	nm³

SASDUS4 – Calcium/calmodulin-dependent protein kinase type II alpha (CaMKIIα) WT hub domain with PIPA (i)

Calcium/calmodulin-dependent protein kinase type II subunit alpha2-(6-(4-chlorophenyl)imidazo[1,2-b]pyridazine-2-yl)acetic acid experimental SAS data

Sample:	Calcium/calmodulin-dependent protein kinase type II subunit alpha dodecamer, 186 kDa Homo sapiens protein 2-(6-(4-chlorophenyl)imidazo[1,2-b]pyridazine-2-yl)acetic acid monomer, 0 kDa
Buffer:	20 mM MES, 150 mM NaCl, 1 mM DTT, 200 µM PIPA, pH: 6
Experiment:	SAXS data collected at Xenocs BioXolver L with MetalJet, University of Copenhagen, Department of Drug Design and Pharmacology on 2022 Nov 30

R_g^Guinier	4.8	nm
D_max	16.0	nm
Volume^Porod	396	nm³

SASDUT4 – Calcium/calmodulin-dependent protein kinase type II alpha (CaMKIIα) WT hub domain with PIPA (ii)

Sample:	Calcium/calmodulin-dependent protein kinase type II subunit alpha dodecamer, 186 kDa Homo sapiens protein 2-(6-(4-chlorophenyl)imidazo[1,2-b]pyridazine-2-yl)acetic acid monomer, 0 kDa
Buffer:	20 mM MES, 150 mM NaCl, 1 mM DTT, 200 µM PIPA, pH: 6
Experiment:	SAXS data collected at Xenocs BioXolver L with MetalJet, University of Copenhagen, Department of Drug Design and Pharmacology on 2023 May 30

R_g^Guinier	5.5	nm
D_max	27.0	nm

SASDUU4 – Calcium/calmodulin-dependent protein kinase type II alpha (CaMKIIα) WT hub domain with PIPA (ii-remeasured after storage)

Sample:	Calcium/calmodulin-dependent protein kinase type II subunit alpha dodecamer, 186 kDa Homo sapiens protein 2-(6-(4-chlorophenyl)imidazo[1,2-b]pyridazine-2-yl)acetic acid monomer, 0 kDa
Buffer:	20 mM MES, 150 mM NaCl, 1 mM DTT, 200 µM PIPA, pH: 6
Experiment:	SAXS data collected at Xenocs BioXolver L with MetalJet, University of Copenhagen, Department of Drug Design and Pharmacology on 2023 May 31

R_g^Guinier	8.8	nm
D_max	37.0	nm

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