Dimerization of kringle 1 domain from hepatocyte growth factor/scatter factor provides a potent MET receptor agonist

de Nola G, Leclercq B, Mougel A, Taront S, Simonneau C, Forneris F, Adriaenssens E, Drobecq H, Iamele L, Dubuquoy L, Melnyk O, Gherardi E, de Jonge H, Vicogne J
Life Science Alliance 5(12):e202201424 (2022 Jul 29)

doi: 10.26508/lsa.202201424

Submitted to SASBDB: 2021 Jul 20 Published in SASBDB: 2022 Jul 20

SASDLM9 – Minimal hepatocyte growth factor mimic K1K1 Sample: Minimal hepatocyte growth factor mimic K1K1 monomer, 19 kDa synthetic construct protein Buffer: 25 mM Tris, 150 mM NaCl, pH: 7.4 Experiment: SAXS data collected at BM29, ESRF on 2016 Nov 3 RgGuinier 2.2 nm Dmax 6.6 nm VolumePorod 22 nm3

SASDLN9 – Hepatocyte growth factor HGF/SF receptor - fragment MET567 Sample: Hepatocyte growth factor receptor monomer, 62 kDa Homo sapiens protein Buffer: 25 mM Tris, 150 mM NaCl, pH: 7.4 Experiment: SAXS data collected at BM29, ESRF on 2018 Jan 27 RgGuinier 3.2 nm Dmax 11.7 nm VolumePorod 126 nm3

SASDLP9 – Hepatocyte growth factor HGF/SF receptor - fragment MET567 in complex with the minimal hepatocyte growth factor mimic K1K1 Sample: Minimal hepatocyte growth factor mimic K1K1 monomer, 19 kDa synthetic construct protein Hepatocyte growth factor receptor monomer, 62 kDa Homo sapiens protein Buffer: 25 mM Tris, 150 mM NaCl, pH: 7.4 Experiment: SAXS data collected at BM29, ESRF on 2018 Jan 23 RgGuinier 3.7 nm Dmax 14.3 nm VolumePorod 136 nm3