Macromolecular HPMA-based nanoparticles with cholesterol for solid-tumor targeting: detailed study of the inner structure of a highly efficient drug delivery system.

Filippov SK, Chytil P, Konarev PV, Dyakonova M, Papadakis C, Zhigunov A, Plestil J, Stepanek P, Etrych T, Ulbrich K, Svergun DI
Biomacromolecules 13(8):2594-604 (2012 Aug 13)

PMID: 22793269 doi: 10.1021/bm3008555

Submitted to SASBDB: 2021 Aug 16 Published in SASBDB: 2021 Aug 18

SASDMR2 – HPMA-Based Nanoparticles with Cholesterol (1.4%) Sample: N-(2-hydroxypropyl)- 31 methacrylamide (HPMA) copolymers with cholesterol 1.4% 0, 16272 kDa Buffer: phosphate buffer saline (PBS) (pH 5.0), pH: 5 Experiment: SAXS data collected at EMBL X33, DORIS III, DESY on 2011 Mar 27 RgGuinier 6.2 nm Dmax 22.0 nm

SASDMS2 – HPMA-Based Nanoparticles with Cholesterol (2.7%) Sample: N-(2-hydroxypropyl)- 31 methacrylamide (HPMA) copolymers with Cholesterol (2.7%) 0, 16740 kDa Buffer: phosphate buffer saline (PBS) (pH 7.2), pH: 7.2 Experiment: SAXS data collected at EMBL X33, DORIS III, DESY on 2011 Mar 27 RgGuinier 5.2 nm Dmax 28.1 nm

SASDMT2 – HPMA-Based Nanoparticles with Cholesterol (3.0%) Sample: N-(2-hydroxypropyl)- 31 methacrylamide (HPMA) copolymers with Cholesterol (3.0%) 0, 29520 kDa Buffer: phosphate buffer saline (PBS) (pH 5.0), pH: 5 Experiment: SAXS data collected at EMBL X33, DORIS III, DESY on 2011 Mar 27 RgGuinier 9.4 nm Dmax 43.2 nm