The two non-visual arrestins engage ERK2 differently.

Perry-Hauser NA, Bennett Hopkins J, Zhuo Y, Zheng C, Perez I, Schultz KM, Vishnivetskiy SA, Kaya AI, Sharma P, Dalby KN, Young Chung K, Klug CS, Gurevich VV, Iverson TM
J Mol Biol :167465 (2022 Jan 22)

PMID: 35077767 doi: 10.1016/j.jmb.2022.167465

Submitted to SASBDB: 2021 Aug 31 Published in SASBDB: 2022 Feb 2

SASDMG4 – Arrestin-3 ERK2 fusion, monomer (Arrestin-3 fused to extracellular signal-regulated kinase 2) Sample: Arrestin-3 fused to extracellular signal-regulated kinase 2 monomer, 89 kDa Bos taurus/Rattus norvegicus protein Buffer: 20 mM MOPS pH 7.5, 150 mM NaCl, 1 mM TCEP, and 5% glycerol, pH: 7.5 Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2019 Mar 23 RgGuinier 3.6 nm Dmax 14.0 nm

SASDMH4 – Arrestin-3 ERK2 fusion, dimer (Arrestin-3 fused to extracellular signal-regulated kinase 2) Sample: Arrestin-3 fused to extracellular signal-regulated kinase 2 dimer, 178 kDa Bos taurus/Rattus norvegicus protein Buffer: 20 mM MOPS pH 7.5, 150 mM NaCl, 1 mM TCEP, and 5% glycerol, pH: 7.5 Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2019 Mar 23 RgGuinier 4.3 nm Dmax 16.0 nm