Structure and activation of C1, the complex initiating the classical pathway of the complement cascade.

Mortensen SA, Sander B, Jensen RK, Pedersen JS, Golas MM, Jensenius JC, Hansen AG, Thiel S, Andersen GR
Proc Natl Acad Sci U S A 114(5):986-991 (2017 Jan 31)

PMID: 28104818 doi: 10.1073/pnas.1616998114

Submitted to SASBDB: 2016 Dec 2 Published in SASBDB: 2017 Jan 9

SASDBZ7 – Complement factor 1s in complex with Complement factor 1r Sample: Complement C1r subcomponent dimer, 156 kDa Homo sapiens protein Complement C1s subcomponent dimer, 150 kDa Homo sapiens protein Buffer: 50 mM TrisHCl, 145 mM NaCl, 3 mM CaCl2, pH: 7.4 Experiment: SAXS data collected at BM29, ESRF on 2014 Dec 8 RgGuinier 11.6 nm

SASDB28 – Complement factor 1q (C1q) Sample: Complement C1q subcomponent subunit C hexamer, 142 kDa Homo sapiens protein Complement C1q subcomponent subunit B hexamer, 142 kDa Homo sapiens protein Complement C1q subcomponent subunit A hexamer, 142 kDa Homo sapiens protein Buffer: 50 mM TrisHCl, 145 mM NaCl, 3 mM CaCl2, pH: 7.4 Experiment: SAXS data collected at BM29, ESRF on 2014 Dec 8 RgGuinier 12.6 nm

SASDB38 – Inactivated complement factor 1 (C1) Sample: Complement C1q subcomponent subunit C hexamer, 142 kDa Homo sapiens protein Complement C1q subcomponent subunit B hexamer, 142 kDa Homo sapiens protein Complement C1q subcomponent subunit A hexamer, 142 kDa Homo sapiens protein Complement C1r subcomponent dimer, 156 kDa Homo sapiens protein Complement C1s subcomponent dimer, 150 kDa Homo sapiens protein Buffer: 50 mM EPPS, 145 mM NaCl, 3 mM CaCl2, pH: 8.5 Experiment: SAXS data collected at EMBL P12, PETRA III on 2015 Aug 16 RgGuinier 11.5 nm Dmax 36.6 nm