Structural flexibility of the human vault particle revealed by high-resolution cryo-EM and molecular dynamics simulations.

Lapenta F, Palacio-Rodriguez K, Cruz-León S, Marrancone S, Aupič J, Marechal N, Durand A, Moussaoui D, Covaceuszach S, Gangupam B, D'Ercole C, Parra C, Cotugno D, Tomaino G, Tortora P, de Marco A, Cassetta A, Magistrato A, Hummer G
Nat Commun (2026 May 2)

PMID: 42069735 doi: 10.1038/s41467-026-72674-4

Submitted to SASBDB: 2025 Apr 11 Published in SASBDB: 2026 Apr 27

SASDXJ3 – Human major vault protein Sample: Major vault protein, 7747 kDa Homo sapiens protein Buffer: 25 mM HEPES, 150 mM NaCl, 1 mM TCEP, pH: 7.5 Experiment: SAXS data collected at BM29, ESRF on 2022 Jun 8 RgGuinier 16.3 nm Dmax 65.0 nm VolumePorod 16650 nm3