Structural flexibility of the human vault particle revealed by high-resolution cryo-EM and molecular dynamics simulations

SASDXJ3 – Human major vault protein Sample: Major vault protein, 7747 kDa Homo sapiens protein Buffer: 25 mM HEPES, 150 mM NaCl, 1 mM TCEP, pH: 7.5 Experiment: SAXS data collected at BM29, ESRF on 2022 Jun 8 RgGuinier 16.3 nm Dmax 65.0 nm VolumePorod 16650 nm3