CD2AP’s Structure and Oligomerization are compromised by the K301M mutation: implications for Nephrotic syndrome

Anil Kumar Pasupulati et .al Submitted to SASBDB: 2025 Jul 16
Published in SASBDB:

SASDXJ6 – CD2-associated protein (CD2AP)

CD2-associated protein experimental SAS data
CD2-associated protein Kratky plot
Sample: CD2-associated protein hexamer, 429 kDa Homo sapiens protein
Buffer: 10 mM potassium phosphate, pH: 7.6
Experiment: SAXS data collected at Anton Paar SAXSpace, CSIR-Central Drug Research Institute on 2025 May 16
RgGuinier 10.7 nm
Dmax 35.5 nm

SASDXK6 – CD2-associated protein (CD2AP) K301M point mutant

CD2-associated protein experimental SAS data
CD2-associated protein Kratky plot
Sample: CD2-associated protein trimer, 214 kDa Homo sapiens protein
Buffer: 10 mM potassium phosphate, pH: 7.6
Experiment: SAXS data collected at Anton Paar SAXSpace, CSIR-Central Drug Research Institute on 2025 May 18
RgGuinier 9.6 nm
Dmax 33.9 nm