Integrative structural analysis of human endosomal NHE6 reveals a lipid-associated gate and disordered C-terminus

Feilen L, Sach L, Tranchant E, Lalic M, Havelund J, Jeria Cerda C, Ginsthofer M, Ostendorf J, Ma L, Morrow E, Færgeman N, Pedersen S, Kragelund B, Autzen H
Nature Communications (2026 Aug 11)

doi: 10.1038/s41467-026-76368-9

Submitted to SASBDB: 2025 Jul 9 Published in SASBDB: 2026 Jul 3

SASDXC6 – Sodium/hydrogen exchanger 6 protein (HsNHE6) C-terminal end (G586-A701) Sample: Sodium/hydrogen exchanger 6 monomer, 13 kDa Homo sapiens protein Buffer: 20 mM HEPES, 150 mM NaCl, 5 mM DTT, pH: 7.4 Experiment: SAXS data collected at EMBL P12, PETRA III on 2024 Dec 14 RgGuinier 3.1 nm