Atomistic scattering modelling of the solution structure of human dimeric IgA1 reveals a structural and mechanistic basis for IgA nephropathy.

Bhatt JS, Yeo SC, Ireland SM, Ben-Younis A, Gor J, Molyneux K, Barratt J, Perkins SJ
J Biol Chem :113156 (2026 May 14)
PMID: 42140437
doi: 10.1016/j.jbc.2026.113156 		Submitted to SASBDB: 2025 Nov 29
Published in SASBDB:

SASDYW2 – IgA1 dimer - Control

Human immunoglobulin IgA1 experimental SAS data
CUSTOM IN-HOUSE model
Sample: Human immunoglobulin IgA1 dimer, 320 kDa protein
Buffer: 8.2 mM Na2HPO4, 1.5 mM KH2PO4, 137 mM NaCl, 2.6 mM KCl (PBS), pH: 7.4
Experiment: SAXS data collected at BM29, ESRF on 2014 Sep 7
RgGuinier 8.7 nm
Dmax 35.0 nm

SASDYX2 – IgA1 dimer - Patient A

Human immunoglobulin IgA1 experimental SAS data
CUSTOM IN-HOUSE model
Sample: Human immunoglobulin IgA1 dimer, 320 kDa protein
Buffer: PBS buffer, 137 mM NaCl, 8.2 mM Na2HPO4, 2.6 mM KCl, 1.5 mM KH2PO4, pH: 7.4
Experiment: SAXS data collected at BM29, ESRF on 2014 Sep 7
RgGuinier 8.6 nm
Dmax 35.0 nm

SASDYY2 – IgA1 dimer - Patient B

Human immunoglobulin IgA1 experimental SAS data
CUSTOM IN-HOUSE model
Sample: Human immunoglobulin IgA1 dimer, 320 kDa protein
Buffer: PBS buffer, 137 mM NaCl, 8.2 mM Na2HPO4, 2.6 mM KCl, 1.5 mM KH2PO4, pH: 7.4
Experiment: SAXS data collected at BM29, ESRF on 2014 Sep 7
RgGuinier 8.4 nm
Dmax 35.0 nm

SASDYZ2 – IgA1 dimer - Patient C

Human immunoglobulin IgA1 experimental SAS data
CUSTOM IN-HOUSE model
Sample: Human immunoglobulin IgA1 dimer, 320 kDa protein
Buffer: PBS buffer, 137 mM NaCl, 8.2 mM Na2HPO4, 2.6 mM KCl, 1.5 mM KH2PO4, pH: 7.4
Experiment: SAXS data collected at BM29, ESRF on 2014 Sep 7
RgGuinier 8.5 nm
Dmax 35.0 nm