Ligands reshape the compactness, stability, and topology of telomeric G-quadruplex dimers.

Bertini L, Libera V, Arciuolo V, Trapella M, Marzano S, Mostarac D, Schirò G, Petrillo C, Giancola C, De Michele C, Amato J, Comez L, Pagano B, Paciaroni A
Nucleic Acids Res 54(8) (2026 Apr 23)
PMID: 42080259
doi: 10.1093/nar/gkag403 		Submitted to SASBDB: 2025 Dec 11
Published in SASBDB:

SASDY63 – human telomeric g-quadruplex (Tel50)

human telomeric g-quadruplex experimental SAS data
human telomeric g-quadruplex Kratky plot
Sample: Human telomeric g-quadruplex, 16 kDa DNA
Buffer: 5 mM KH2PO4/K2HPO4, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2024 Jul 12
RgGuinier 2.1 nm

SASDY73 – human telomeric g-quadruplex (Tel26)

human telomeric g-quadruplex experimental SAS data
human telomeric g-quadruplex Kratky plot
Sample: Human telomeric g-quadruplex monomer, 8 kDa DNA
Buffer: 5 mM KH2PO4/K2HPO4, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2024 Jul 12
RgGuinier 1.3 nm

SASDY83 – human telomeric g-quadruplex Tel50+BRACO-19 (1:2)

human telomeric g-quadruplex experimental SAS data
human telomeric g-quadruplex Kratky plot
Sample: Human telomeric g-quadruplex, 16 kDa DNA
Buffer: 5 mM KH2PO4/K2HPO4, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2024 Jul 12
RgGuinier 2.0 nm

SASDY93 – human telomeric g-quadruplex Tel50+BRACO-19 (1:3)

human telomeric g-quadruplex experimental SAS data
human telomeric g-quadruplex Kratky plot
Sample: Human telomeric g-quadruplex, 16 kDa DNA
Buffer: 5 mM KH2PO4/K2HPO4, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2024 Jul 12
RgGuinier 2.0 nm

SASDYA3 – human telomeric g-quadruplex Tel50+BRACO-19 (1:4)

human telomeric g-quadruplex experimental SAS data
human telomeric g-quadruplex Kratky plot
Sample: Human telomeric g-quadruplex, 16 kDa DNA
Buffer: 5 mM KH2PO4/K2HPO4, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2024 Jul 12
RgGuinier 2.0 nm

SASDYB3 – human telomeric g-quadruplex Tel50+PhenDC3 (1:2)

human telomeric g-quadruplex experimental SAS data
human telomeric g-quadruplex Kratky plot
Sample: Human telomeric g-quadruplex, 16 kDa DNA
Buffer: 5 mM KH2PO4/K2HPO4, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2024 Jul 12
RgGuinier 2.0 nm

SASDYC3 – human telomeric g-quadruplex Tel50+PhenDC3 (1:3)

human telomeric g-quadruplex experimental SAS data
human telomeric g-quadruplex Kratky plot
Sample: Human telomeric g-quadruplex, 16 kDa DNA
Buffer: 5 mM KH2PO4/K2HPO4, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2024 Jul 12
RgGuinier 2.0 nm

SASDYD3 – human telomeric g-quadruplex Tel50+PhenDC3 (1:4)

human telomeric g-quadruplex experimental SAS data
human telomeric g-quadruplex Kratky plot
Sample: Human telomeric g-quadruplex, 16 kDa DNA
Buffer: 5 mM KH2PO4/K2HPO4, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2024 Jul 12
RgGuinier 2.0 nm

SASDYE3 – human telomeric G-quadruplex Tel50+RHPS4 (1:2)

human telomeric g-quadruplex experimental SAS data
human telomeric g-quadruplex Kratky plot
Sample: Human telomeric g-quadruplex, 16 kDa DNA
Buffer: 5 mM KH2PO4/K2HPO4, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2024 Jul 12
RgGuinier 2.0 nm

SASDYF3 – human telomeric g-quadruplex Tel50+RHPS4(1:3)

human telomeric g-quadruplex experimental SAS data
human telomeric g-quadruplex Kratky plot
Sample: Human telomeric g-quadruplex, 16 kDa DNA
Buffer: 5 mM KH2PO4/K2HPO4, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2024 Jul 12
RgGuinier 2.0 nm

SASDYG3 – human telomeric g-quadruplex Tel50+RHPS4(1:4)

human telomeric g-quadruplex experimental SAS data
human telomeric g-quadruplex Kratky plot
Sample: Human telomeric g-quadruplex, 16 kDa DNA
Buffer: 5 mM KH2PO4/K2HPO4, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2024 Jul 12
RgGuinier 2.0 nm

SASDYH3 – human telomeric g-quadruplex Tel50+SYUIQ-5 (1:2)

human telomeric g-quadruplex experimental SAS data
human telomeric g-quadruplex Kratky plot
Sample: Human telomeric g-quadruplex, 16 kDa DNA
Buffer: 5 mM KH2PO4/K2HPO4, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2024 Jul 12
RgGuinier 2.0 nm

SASDYJ3 – human telomeric g-quadruplex Tel50+SYUIQ-5 (1:3)

human telomeric g-quadruplex experimental SAS data
human telomeric g-quadruplex Kratky plot
Sample: Human telomeric g-quadruplex, 16 kDa DNA
Buffer: 5 mM KH2PO4/K2HPO4, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2024 Jul 12
RgGuinier 1.9 nm

SASDYK3 – human telomeric g-quadruplex Tel50+SYUIQ-5 (1:4)

human telomeric g-quadruplex experimental SAS data
human telomeric g-quadruplex Kratky plot
Sample: Human telomeric g-quadruplex, 16 kDa DNA
Buffer: 5 mM KH2PO4/K2HPO4, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2024 Jul 12
RgGuinier 1.9 nm

SASDYL3 – human telomeric g-quadruplex Tel26+BRACO-19 (1:1)

human telomeric g-quadruplex experimental SAS data
human telomeric g-quadruplex Kratky plot
Sample: Human telomeric g-quadruplex monomer, 8 kDa DNA
Buffer: 5 mM KH2PO4/K2HPO4, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2024 Jul 12
RgGuinier 1.3 nm

SASDYM3 – human telomeric g-quadruplex Tel26+BRACO-19 (1:2)

human telomeric g-quadruplex experimental SAS data
human telomeric g-quadruplex Kratky plot
Sample: Human telomeric g-quadruplex monomer, 8 kDa DNA
Buffer: 5 mM KH2PO4/K2HPO4, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2024 Jul 12
RgGuinier 1.3 nm

SASDYN3 – human telomeric g-quadruplex Tel26+PhenDC3 (1:1)

human telomeric g-quadruplex experimental SAS data
human telomeric g-quadruplex Kratky plot
Sample: Human telomeric g-quadruplex monomer, 8 kDa DNA
Buffer: 5 mM KH2PO4/K2HPO4, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2024 Jul 12
RgGuinier 1.3 nm

SASDYP3 – human telomeric g-quadruplex Tel26+RHPS4 (1:1)

human telomeric g-quadruplex experimental SAS data
human telomeric g-quadruplex Kratky plot
Sample: Human telomeric g-quadruplex monomer, 8 kDa DNA
Buffer: 5 mM KH2PO4/K2HPO4, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2024 Jul 12
RgGuinier 1.3 nm

SASDYQ3 – human telomeric g-quadruplex Tel26+PhenDC3 (1:2)

human telomeric g-quadruplex experimental SAS data
human telomeric g-quadruplex Kratky plot
Sample: Human telomeric g-quadruplex monomer, 8 kDa DNA
Buffer: 5 mM KH2PO4/K2HPO4, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2024 Jul 12
RgGuinier 1.3 nm

SASDYR3 – human telomeric g-quadruplex Tel26+RHPS4 (1:2)

human telomeric g-quadruplex experimental SAS data
human telomeric g-quadruplex Kratky plot
Sample: Human telomeric g-quadruplex monomer, 8 kDa DNA
Buffer: 5 mM KH2PO4/K2HPO4, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2024 Jul 12
RgGuinier 1.3 nm

SASDYS3 – human telomeric g-quadruplex Tel26+SYUIQ-5 (1:1)

human telomeric g-quadruplex experimental SAS data
human telomeric g-quadruplex Kratky plot
Sample: Human telomeric g-quadruplex monomer, 8 kDa DNA
Buffer: 5 mM KH2PO4/K2HPO4, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2024 Jul 12
RgGuinier 1.3 nm

SASDYT3 – human telomeric g-quadruplex Tel26+SYUIQ-5 (1:2)

human telomeric g-quadruplex experimental SAS data
human telomeric g-quadruplex Kratky plot
Sample: Human telomeric g-quadruplex monomer, 8 kDa DNA
Buffer: 5 mM KH2PO4/K2HPO4, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2024 Jul 12
RgGuinier 1.3 nm