Human lncRNA RMRP interacts with DEAD-box helicases and modulates mitochondrial function.

Pereira HS, Luddu J, Veerareddygari GR, Sanghvi SK, Patel PB, Robinson ZE, Siddiqui MQ, Singh H, Patel TR
Proc Natl Acad Sci U S A 123(8):e2522583123 (2026 Feb 24)
PMID: 41719330
doi: 10.1073/pnas.2522583123 		Submitted to SASBDB: 2025 Dec 19
Published in SASBDB:

SASDYD4 – RNA component of mitochondrial RNA processing endoribonuclease (RMRP in 5 mM Mg2+)

RMRP experimental SAS data
DAMMIN model
Sample: RMRP monomer, 90 kDa Homo sapiens RNA
Buffer: 10 mM Bis-Tris, 100 mM NaCl, 5 mM MgCl2, pH: 6.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2022 Mar 1
RgGuinier 7.1 nm
Dmax 23.0 nm
VolumePorod 316 nm3

SASDYE4 – RNA component of mitochondrial RNA processing endoribonuclease (RMRP in 20 mM Mg2+)

RMRP experimental SAS data
DAMMIN model
Sample: RMRP monomer, 91 kDa Homo sapiens RNA
Buffer: 10 mM Bis-Tris, 100 mM NaCl, 5 mM MgCl2, pH: 6.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2022 Mar 1
RgGuinier 5.8 nm
Dmax 18.0 nm
VolumePorod 205 nm3