A structure-based epitope tagging approach identifies vulnerable sites on the malarial P36-P52 protein complex for antibody-mediated neutralization of Plasmodium sporozoites.

Das S, Boeykens L, Loubens M, Marinach C, Briquet S, De Vocht L, Pintelon I, Timmermans JP, Sterckx YG, Silvie O
PLoS Pathog 22(7):e1014418 (2026 Jul)

PMID: 42418521 doi: 10.1371/journal.ppat.1014418

Submitted to SASBDB: 2026 Jan 19 Published in SASBDB: 2026 Aug 27

SASDY36 – Plasmodium falciparum P52-P36 fusion protein Sample: Plasmodium falciparum P52-P36 fusion protein monomer, 84 kDa protein Buffer: 20 mM HEPES, 200 mM NaCl, 3% glycerol, pH: 8 Experiment: SAXS data collected at SWING, SOLEIL on 2025 Jun 25 RgGuinier 4.1 nm Dmax 20.8 nm VolumePorod 180 nm3