The hearing-essential intracellular domain of PCDH15 reveals a new layer of auditory mechanotransduction

Van de Velde J, Bighiu R, Mandal N, Lapouge K, Skepo M, Sterckx Y, Petit C, Van Rompaey V, Van Wielendaele P
(2026 Sep 19)

doi: 10.64898/2026.09.17.752191

Submitted to SASBDB: 2026 Sep 15 Published in SASBDB: 2026 Sep 23

SASD2B8 – Recombinant CD2-specific cytoplasmic region of mouse protocadherin-15 in 10 mM NaCl Sample: Tag + Intracellular region of Isoform 10 of Protocadherin-15 monomer, 42 kDa Mus musculus protein Buffer: 20 mM Tris, 10 mM NaCl, pH: 8 Experiment: SAXS data collected at BM29, ESRF on 2025 Sep 27 RgGuinier 6.0 nm Dmax 23.9 nm

SASD2C8 – Recombinant CD2-specific cytoplasmic region of mouse protocadherin-15 in 150 mM NaCl Sample: Tag + Intracellular region of Isoform 10 of Protocadherin-15 monomer, 42 kDa Mus musculus protein Buffer: 20 mM Tris-HCl, 150 mM NaCl, pH: 8 Experiment: SAXS data collected at BM29, ESRF on 2025 Sep 27 RgGuinier 7.8 nm Dmax 36.5 nm