Non-syndromic Mitral Valve Dysplasia Mutation Changes the Force Resilience and Interaction of Human Filamin A.

Haataja TJK, Bernardi RC, Lecointe S, Capoulade R, Merot J, Pentikäinen U
Structure (2018 Oct 9)
PMID: 30344108
doi: 10.1016/j.str.2018.09.007 		Submitted to SASBDB: 2018 Nov 12
Published in SASBDB:

SASDEQ7 – Filamin A Ig-like domains 3-5 (FLNa3-5)

Filamin A Ig-like domains 3-5 experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Filamin A Ig-like domains 3-5 monomer, 31 kDa Homo sapiens protein
Buffer: 20 mM Tris, 100 mM NaCl, 1 mM DTT, pH: 8
Experiment: SAXS data collected at BM29, ESRF on 2017 Feb 10
RgGuinier 2.2 nm
Dmax 7.3 nm
VolumePorod 39 nm3

SASDEP7 – Filamin A Ig-like domains 3-5 P637Q mutant (FLNa3-5 P637Q)

Filamin A Ig.like domains 3-5 P637Q mutant experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Filamin A Ig.like domains 3-5 P637Q mutant monomer, 31 kDa Homo sapiens protein
Buffer: 20 mM Tris, 100 mM NaCl, 1 mM DTT, pH: 8
Experiment: SAXS data collected at BM29, ESRF on 2017 Feb 10
RgGuinier 2.2 nm
Dmax 7.4 nm
VolumePorod 39 nm3