Structural Basis of Membrane Protein Chaperoning through the Mitochondrial Intermembrane Space.

Weinhäupl K, Lindau C, Hessel A, Wang Y, Schütze C, Jores T, Melchionda L, Schönfisch B, Kalbacher H, Bersch B, Rapaport D, Brennich M, Lindorff-Larsen K, Wiedemann N, Schanda P
Cell 175(5):1365-1379.e25 (2018 Nov 15)

PMID: 30445040 doi: 10.1016/j.cell.2018.10.039

Submitted to SASBDB: 2018 Aug 13 Published in SASBDB: 2018 Nov 21

SASDEF2 – Mitochondrial import inner membrane translocase complex TIM9·10 Sample: Mitochondrial import inner membrane translocase subunit TIM9 trimer, 31 kDa Saccharomyces cerevisiae protein Mitochondrial import inner membrane translocase subunit TIM10 trimer, 31 kDa Saccharomyces cerevisiae protein Buffer: 50mM Tris, 150mM NaCl, pH: 7.4 Experiment: SAXS data collected at BM29, ESRF on 2015 Aug 27 RgGuinier 2.7 nm Dmax 10.0 nm VolumePorod 103 nm3

SASDEG2 – Mitochondrial import inner membrane translocase complex TIM9·10 in complex with a precursor (GDP/GTP carrier (Ggc1)) Sample: Mitochondrial import inner membrane translocase subunit TIM9 hexamer, 61 kDa Saccharomyces cerevisiae protein Mitochondrial import inner membrane translocase subunit TIM10 hexamer, 61 kDa Saccharomyces cerevisiae protein Mitochondrial GTP/GDP carrier protein 1 monomer, 33 kDa Saccharomyces cerevisiae protein Buffer: 50mM Tris, 150mM NaCl, imidiazole, pH: 7.4 Experiment: SAXS data collected at BM29, ESRF on 2016 Feb 22 RgGuinier 4.5 nm Dmax 16.0 nm VolumePorod 272 nm3