Structure of a collagen VI α3 chain VWA domain array: adaptability and functional implications of myopathy causing mutations

Solomon-Degefa H, Gebauer J, Jeffries C, Freiburg C, Meckelburg P, Bird L, Baumann U, Svergun D, Owens R, Werner J, Behrmann E, Paulsson M, Wagener R
Journal of Biological Chemistry :jbc.RA120.014865 (2020 Jul 21)

doi: 10.1074/jbc.RA120.014865

Published in SASBDB: 2020 Jul 25

SASDEY9 – Collagen VI von Willebrand factor (VWA) double-domain fragment, N5N4 Sample: Collagen, type VI, alpha 3 monomer, 44 kDa Mus musculus protein Buffer: 20 mM TRIS, 150mM NaCl 3% v/v glycerol, pH: 7.4 Experiment: SAXS data collected at EMBL P12, PETRA III on 2018 Apr 20 RgGuinier 2.9 nm Dmax 9.9 nm VolumePorod 66 nm3

SASDEZ9 – Collagen VI von Willebrand factor (VWA) four-domain fragment, N6N3 Sample: Collagen, type VI, alpha 3 monomer, 93 kDa Mus musculus protein Buffer: 20 mM TRIS, 150mM NaCl 3% v/v glycerol, pH: 7.4 Experiment: SAXS data collected at EMBL P12, PETRA III on 2018 Nov 4 RgGuinier 4.1 nm Dmax 15.6 nm VolumePorod 143 nm3

SASDJJ4 – Collagen VI von Willebrand factor (VWA) N2 domain Sample: Collagen alpha-3(VI) chain, N2 domain monomer, 22 kDa Homo sapiens protein Buffer: 20 mM TRIS, pH 7.4, 150mM NaCl 3% v/v glycerol, pH: 7.4 Experiment: SAXS data collected at EMBL P12, PETRA III on 2018 May 4 RgGuinier 1.8 nm Dmax 5.8 nm VolumePorod 40 nm3