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4 hits found for Higgins

SASDUW6 – Alarmin release inhibitor (HpARI2), full-length

Alarmin release inhibitor (Δ1-62) experimental SAS data
DAMMIF model
Sample: Alarmin release inhibitor (Δ1-62) monomer, 26 kDa Heligmosomoides polygyrus protein
Buffer: 137 mM NaCl, 2.7 mM KCl, 10 mM phosphate buffer, 5% glycerol, pH: 7.2
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Feb 9
Structural basis for IL-33 recognition and its antagonism by the helminth effector protein HpARI2. Nat Commun 15(1):5226 (2024)
...Higgins MK
RgGuinier 2.6 nm
Dmax 9.9 nm
VolumePorod 31 nm3

SASDUX6 – Alarmin release inhibitor (HpARI2) domains CCP2 and CCP3

Alarmin release inhibitor (Δ1-125; N175Q, N190Q) experimental SAS data
DAMMIF model
Sample: Alarmin release inhibitor (Δ1-125; N175Q, N190Q) monomer, 19 kDa Heligmosomoides polygyrus protein
Buffer: 137 mM NaCl, 2.7 mM KCl, 10 mM phosphate buffer, 5% glycerol, pH: 7.2
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Feb 9
Structural basis for IL-33 recognition and its antagonism by the helminth effector protein HpARI2. Nat Commun 15(1):5226 (2024)
...Higgins MK
RgGuinier 2.3 nm
Dmax 8.2 nm
VolumePorod 28 nm3

SASDUY6 – Alarmin release inhibitor (HpARI2), full length, bound to Interleukin-33

Alarmin release inhibitor (Δ1-62)Interleukin-33 (L179V) experimental SAS data
DAMMIF model
Sample: Alarmin release inhibitor (Δ1-62) monomer, 26 kDa Heligmosomoides polygyrus protein
Interleukin-33 (L179V) monomer, 18 kDa Mus musculus protein
Buffer: 137 mM NaCl, 2.7 mM KCl, 10 mM phosphate buffer, 5% glycerol, pH: 7.2
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Feb 9
Structural basis for IL-33 recognition and its antagonism by the helminth effector protein HpARI2. Nat Commun 15(1):5226 (2024)
...Higgins MK
RgGuinier 2.7 nm
Dmax 9.7 nm
VolumePorod 62 nm3

SASDUZ6 – Alarmin release inhibitor (HpARI2) domains CCP2 and CCP3 bound to Interleukin-33

Interleukin-33 (L179V)Alarmin release inhibitor (Δ1-125; N175Q, N190Q) experimental SAS data
REFMAC model
Sample: Interleukin-33 (L179V) monomer, 18 kDa Mus musculus protein
Alarmin release inhibitor (Δ1-125; N175Q, N190Q) monomer, 19 kDa Heligmosomoides polygyrus protein
Buffer: 137 mM NaCl, 2.7 mM KCl, 10 mM phosphate buffer, 5% glycerol, pH: 7.2
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Feb 9
Structural basis for IL-33 recognition and its antagonism by the helminth effector protein HpARI2. Nat Commun 15(1):5226 (2024)
...Higgins MK
RgGuinier 2.5 nm
Dmax 8.3 nm
VolumePorod 58 nm3