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10 hits found for Sutton

SASDDP6 – Anti-CD32b Antibody Clone 6G08 Antibody Binding Fragment (6G08 F(ab))

Anti-CD32b Antibody Clone 6G08 Antibody Binding Fragment experimental SAS data
Anti-CD32b Antibody Clone 6G08 Antibody Binding Fragment Kratky plot
Sample: Anti-CD32b Antibody Clone 6G08 Antibody Binding Fragment monomer, 46 kDa Homo sapiens protein
Buffer: 50mM HEPES, 150mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2014 Dec 5
Evaluating Anti-CD32b F(ab) Conformation Using Molecular Dynamics and Small-Angle X-Ray Scattering. Biophys J 115(2):289-299 (2018)
Sutton EJ, Bradshaw RT, Orr CM, Frendéus B, Larsson G, Teige I, Cragg MS, Tews I, Essex JW
RgGuinier 2.6 nm
Dmax 7.3 nm
VolumePorod 68 nm3

SASDU77 – Human IgG1 F(ab') 5C05

Human IgG1 F(ab') 5C05 experimental SAS data
Human IgG1 F(ab') 5C05 Kratky plot
Sample: Human IgG1 F(ab') 5C05 monomer, 46 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2016 May 9
Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling. Immunity (2026)
...Sutton EJ, Oldham RJ, Bradshaw RT, Duriez PJ, Frendéus B, Larsson G, Manfredi G, Martin-Fernandez ML, Mockridge I, Needham SR, Rolfe DJ, Orr CM, Patel K, Roghanian A, Simpson A, Tully MD, Teige I, Tor...
RgGuinier 2.5 nm
Dmax 7.7 nm
VolumePorod 59 nm3

SASDU87 – Deglycosylated Fc gamma receptor IIb (CD32b) extracellular domain in complex with human IgG1 5C05 F(ab')

Low affinity immunoglobulin gamma Fc region receptor II-bHuman IgG1 F(ab') 5C05 experimental SAS data
MOLECULAR DYNAMICS FRAME model
Sample: Low affinity immunoglobulin gamma Fc region receptor II-b monomer, 20 kDa Homo sapiens protein
Human IgG1 F(ab') 5C05 monomer, 46 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2016 May 18
Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling. Immunity (2026)
...Sutton EJ, Oldham RJ, Bradshaw RT, Duriez PJ, Frendéus B, Larsson G, Manfredi G, Martin-Fernandez ML, Mockridge I, Needham SR, Rolfe DJ, Orr CM, Patel K, Roghanian A, Simpson A, Tully MD, Teige I, Tor...
RgGuinier 3.5 nm
Dmax 14.0 nm
VolumePorod 95 nm3

SASDU97 – Human IgG1 F(ab') 6C11

Human IgG1 F(ab') 6C11 experimental SAS data
Human IgG1 F(ab') 6C11 Kratky plot
Sample: Human IgG1 F(ab') 6C11 monomer, 24 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2016 May 9
Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling. Immunity (2026)
...Sutton EJ, Oldham RJ, Bradshaw RT, Duriez PJ, Frendéus B, Larsson G, Manfredi G, Martin-Fernandez ML, Mockridge I, Needham SR, Rolfe DJ, Orr CM, Patel K, Roghanian A, Simpson A, Tully MD, Teige I, Tor...
RgGuinier 2.5 nm
Dmax 7.6 nm
VolumePorod 56 nm3

SASDUA7 – Fc gamma receptor IIb (CD32b) extracellular domain in complex with human IgG1 6C11 F(ab')

Low affinity immunoglobulin gamma Fc region receptor II-bHuman IgG1 F(ab') 6C11 experimental SAS data
Low affinity immunoglobulin gamma Fc region receptor II-b Human IgG1 F(ab') 6C11 Kratky plot
Sample: Low affinity immunoglobulin gamma Fc region receptor II-b monomer, 20 kDa Homo sapiens protein
Human IgG1 F(ab') 6C11 monomer, 24 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2016 May 9
Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling. Immunity (2026)
...Sutton EJ, Oldham RJ, Bradshaw RT, Duriez PJ, Frendéus B, Larsson G, Manfredi G, Martin-Fernandez ML, Mockridge I, Needham SR, Rolfe DJ, Orr CM, Patel K, Roghanian A, Simpson A, Tully MD, Teige I, Tor...
RgGuinier 3.4 nm
Dmax 12.0 nm
VolumePorod 110 nm3

SASDUB7 – Human IgG1 F(ab') 6G11

Human IgG1 F(ab') 6G11 experimental SAS data
Human IgG1 F(ab') 6G11 Kratky plot
Sample: Human IgG1 F(ab') 6G11 monomer, 25 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2014 Dec 5
Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling. Immunity (2026)
...Sutton EJ, Oldham RJ, Bradshaw RT, Duriez PJ, Frendéus B, Larsson G, Manfredi G, Martin-Fernandez ML, Mockridge I, Needham SR, Rolfe DJ, Orr CM, Patel K, Roghanian A, Simpson A, Tully MD, Teige I, Tor...
RgGuinier 2.6 nm
Dmax 8.5 nm
VolumePorod 60 nm3

SASDUC7 – Deglycosylated Fc gamma receptor IIb (CD32b) extracellular domain in complex with human IgG1 6G11 F(ab')

Low affinity immunoglobulin gamma Fc region receptor II-bHuman IgG1 F(ab') 6G11 experimental SAS data
MOLECULAR DYNAMICS FRAME model
Sample: Low affinity immunoglobulin gamma Fc region receptor II-b monomer, 20 kDa Homo sapiens protein
Human IgG1 F(ab') 6G11 monomer, 25 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2017 Apr 9
Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling. Immunity (2026)
...Sutton EJ, Oldham RJ, Bradshaw RT, Duriez PJ, Frendéus B, Larsson G, Manfredi G, Martin-Fernandez ML, Mockridge I, Needham SR, Rolfe DJ, Orr CM, Patel K, Roghanian A, Simpson A, Tully MD, Teige I, Tor...
RgGuinier 3.5 nm
Dmax 13.5 nm
VolumePorod 97 nm3

SASDUD7 – Human IgG1 F(ab') 7C07

Human IgG1 F(ab') 7C07 experimental SAS data
Human IgG1 F(ab') 7C07 Kratky plot
Sample: Human IgG1 F(ab') 7C07 monomer, 25 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2014 Dec 5
Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling. Immunity (2026)
...Sutton EJ, Oldham RJ, Bradshaw RT, Duriez PJ, Frendéus B, Larsson G, Manfredi G, Martin-Fernandez ML, Mockridge I, Needham SR, Rolfe DJ, Orr CM, Patel K, Roghanian A, Simpson A, Tully MD, Teige I, Tor...
RgGuinier 2.6 nm
Dmax 8.2 nm
VolumePorod 59 nm3

SASDUE7 – Fc gamma receptor IIb (CD32b) extracellular domain in complex with human IgG1 7C07 F(ab')

Low affinity immunoglobulin gamma Fc region receptor II-bHuman IgG1 F(ab') 7C07 experimental SAS data
Low affinity immunoglobulin gamma Fc region receptor II-b Human IgG1 F(ab') 7C07 Kratky plot
Sample: Low affinity immunoglobulin gamma Fc region receptor II-b monomer, 20 kDa Homo sapiens protein
Human IgG1 F(ab') 7C07 monomer, 25 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2014 Dec 5
Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling. Immunity (2026)
...Sutton EJ, Oldham RJ, Bradshaw RT, Duriez PJ, Frendéus B, Larsson G, Manfredi G, Martin-Fernandez ML, Mockridge I, Needham SR, Rolfe DJ, Orr CM, Patel K, Roghanian A, Simpson A, Tully MD, Teige I, Tor...
RgGuinier 3.6 nm
Dmax 13.5 nm
VolumePorod 110 nm3

SASDUF7 – Deglycosylated Fc gamma receptor IIb (CD32b) extracellular domain in complex with human IgG1 6G08 F(ab')

Low affinity immunoglobulin gamma Fc region receptor II-bHuman IgG1 F(ab') 6G08 experimental SAS data
MOLECULAR DYNAMICS FRAME model
Sample: Low affinity immunoglobulin gamma Fc region receptor II-b monomer, 20 kDa Homo sapiens protein
Human IgG1 F(ab') 6G08 monomer, 24 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2016 Dec 14
Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling. Immunity (2026)
...Sutton EJ, Oldham RJ, Bradshaw RT, Duriez PJ, Frendéus B, Larsson G, Manfredi G, Martin-Fernandez ML, Mockridge I, Needham SR, Rolfe DJ, Orr CM, Patel K, Roghanian A, Simpson A, Tully MD, Teige I, Tor...
RgGuinier 3.3 nm
Dmax 12.0 nm
VolumePorod 96 nm3