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10 hits found for Nuclear receptor corepressor 1

SASDXS2 – RAR/RXR heterodimer : BMS493 : NCoR NID : DR0L element

Retinoic acid receptor alphaBMS493 (RAR inverse agonist ligand)Direct Repeat binding site with zero-base-pair spacing (long sequence)Retinoid X receptor alphaNuclear receptor corepressor 1 experimental SAS data
Retinoic acid receptor alpha BMS493 (RAR inverse agonist ligand) Direct Repeat binding site with zero-base-pair spacing (long sequence) Retinoid X receptor alpha Nuclear receptor corepressor 1 Kratky plot
Sample: ...receptor alpha monomer, 39 kDa Mus musculus protein
BMS493 (RAR inverse agonist ligand) monomer, 0 kDa
Direct Repeat binding site with zero-base-pair spacing (long sequence) monomer, 19 kDa DNA
...receptor alpha monomer, 38 kDa Homo sapiens protein
Nuclear receptor corepressor 1 monomer, 29 kDa Mus musculus protein
Buffer: ...12 mM TCEP, pH: 7.5
Experiment: SAXS data collected at SWING, SOLEIL on ...12
...receptors RAR/RXR by DNA, ligands, and transcriptional coregulators. Nucleic Acids Res 53(18) (2025)
Tambones I, Sagar A, Vankova P, Loginov D, Carivenc C, Rochel N, Bourguet W, Man P, Bernadó P, le Maire A
RgGuinier 5.4 nm
Dmax 20.1 nm
VolumePorod 363 nm3

SASDXT2 – ...1 element

Retinoic acid receptor alphaBMS493 (RAR inverse agonist ligand)Retinoid X receptor alphaDirect Repeat binding site with one-base-pair spacingNuclear receptor corepressor 1 experimental SAS data
Retinoic acid receptor alpha BMS493 (RAR inverse agonist ligand) Retinoid X receptor alpha Direct Repeat binding site with one-base-pair spacing Nuclear receptor corepressor 1 Kratky plot
Sample: ...receptor alpha monomer, 39 kDa Mus musculus protein
BMS493 (RAR inverse agonist ligand) monomer, 0 kDa
...receptor alpha monomer, 38 kDa Homo sapiens protein
Direct Repeat binding site with one-base-pair spacing monomer, 11 kDa DNA
Nuclear receptor corepressor 1 monomer, 29 kDa Mus musculus protein
Buffer: ...12 mM TCEP, pH: 7.5
Experiment: SAXS data collected at SWING, SOLEIL on 2022 Apr 20
...receptors RAR/RXR by DNA, ligands, and transcriptional coregulators. Nucleic Acids Res 53(18) (2025)
Tambones I, Sagar A, Vankova P, Loginov D, Carivenc C, Rochel N, Bourguet W, Man P, Bernadó P, le Maire A
RgGuinier 5.6 nm
Dmax 21.8 nm
VolumePorod 330 nm3

SASDXU2 – RAR/RXR heterodimer : BMS493 : NCoR NID : DR5 element

Retinoic acid receptor alphaBMS493 (RAR inverse agonist ligand)Retinoid X receptor alphaDirect Repeat binding site with five-base-pair spacingNuclear receptor corepressor 1 experimental SAS data
Retinoic acid receptor alpha BMS493 (RAR inverse agonist ligand) Retinoid X receptor alpha Direct Repeat binding site with five-base-pair spacing Nuclear receptor corepressor 1 Kratky plot
Sample: ...receptor alpha monomer, 39 kDa Mus musculus protein
BMS493 (RAR inverse agonist ligand) monomer, 0 kDa
...receptor alpha monomer, 38 kDa Homo sapiens protein
Direct Repeat binding site with five-base-pair spacing monomer, 13 kDa DNA
Nuclear receptor corepressor 1 monomer, 29 kDa Mus musculus protein
Buffer: ...12 mM TCEP, pH: 7.5
Experiment: SAXS data collected at SWING, SOLEIL on ...12
...receptors RAR/RXR by DNA, ligands, and transcriptional coregulators. Nucleic Acids Res 53(18) (2025)
Tambones I, Sagar A, Vankova P, Loginov D, Carivenc C, Rochel N, Bourguet W, Man P, Bernadó P, le Maire A
RgGuinier 5.7 nm
Dmax 21.8 nm
VolumePorod 363 nm3

SASDXV2 – RAR/RXR heterodimer : BMS493 : NCoR NID : IR0 element

Retinoic acid receptor alphaBMS493 (RAR inverse agonist ligand)Retinoid X receptor alphaInverted Repeat binding site with zero-base-pair spacingNuclear receptor corepressor 1 experimental SAS data
Retinoic acid receptor alpha BMS493 (RAR inverse agonist ligand) Retinoid X receptor alpha Inverted Repeat binding site with zero-base-pair spacing Nuclear receptor corepressor 1 Kratky plot
Sample: ...receptor alpha monomer, 39 kDa Mus musculus protein
BMS493 (RAR inverse agonist ligand) monomer, 0 kDa
...receptor alpha monomer, 38 kDa Homo sapiens protein
Inverted Repeat binding site with zero-base-pair spacing monomer, 11 kDa DNA
Nuclear receptor corepressor 1 monomer, 29 kDa Mus musculus protein
Buffer: ...12 mM TCEP, pH: 7.5
Experiment: SAXS data collected at SWING, SOLEIL on 2022 Apr 20
...receptors RAR/RXR by DNA, ligands, and transcriptional coregulators. Nucleic Acids Res 53(18) (2025)
Tambones I, Sagar A, Vankova P, Loginov D, Carivenc C, Rochel N, Bourguet W, Man P, Bernadó P, le Maire A
RgGuinier 5.5 nm
Dmax 22.9 nm
VolumePorod 257 nm3

SASDF34 – ...Nuclear receptor CoRepressor NID (spanning from residue Gln2059 to Glu2325)

Nuclear receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID) experimental SAS data
Sample: Nuclear receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID) monomer, 29 kDa Mus musculus protein
Buffer: ...150 mM NaCl, 2 mM TCEP, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on ...16 Jun 20
...Receptor Heterodimer and Its Corepressor Regulates Gene Expression. Structure (2019)
Cordeiro TN, Sibille N, Germain P, Barthe P, Boulahtouf A, Allemand F, Bailly R, Vivat V, Ebel C, Barducci A, Bourguet W, le Maire A, Bernadó P
RgGuinier 4.7 nm
Dmax 17.7 nm
VolumePorod 102 nm3

SASDF44 – ...1:1)

Nuclear receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID)Retinoid-X receptor alpha (RXR-alpha) Ligand Binding Domain (LBD)Retinoic acid receptor alpha (RAR-alpha) Ligand binding domain (LDB) experimental SAS data
Nuclear receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID) Retinoid-X receptor alpha (RXR-alpha) Ligand Binding Domain (LBD) Retinoic acid receptor alpha (RAR-alpha) Ligand binding domain (LDB) Kratky plot
Sample: Nuclear receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID) monomer, 29 kDa Mus musculus protein
...receptor alpha (RXR-alpha) Ligand Binding Domain (LBD) monomer, 26 kDa Mus musculus protein
...receptor alpha (RAR-alpha) Ligand binding domain (LDB) monomer, 28 kDa Homo sapiens protein
Buffer: ...150 mM NaCl, 2 mM TCEP, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on ...14 Jul 23
...Receptor Heterodimer and Its Corepressor Regulates Gene Expression. Structure (2019)
Cordeiro TN, Sibille N, Germain P, Barthe P, Boulahtouf A, Allemand F, Bailly R, Vivat V, Ebel C, Barducci A, Bourguet W, le Maire A, Bernadó P
RgGuinier 4.8 nm
Dmax 19.4 nm
VolumePorod 167 nm3

SASDF54 – ...12/RAR Heterodimer : N-CoRNID Complex (1:1)

Nuclear receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID)Retinoid-X receptor alpha (RXR-alpha) Ligand Binding Domain (LBD)Retinoid-X receptor alpha (RXR-alpha) Δ helix12 experimental SAS data
Nuclear receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID) Retinoid-X receptor alpha (RXR-alpha) Ligand Binding Domain (LBD) Retinoid-X receptor alpha (RXR-alpha) Δ helix12 Kratky plot
Sample: Nuclear receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID) monomer, 29 kDa Mus musculus protein
...receptor alpha (RXR-alpha) Ligand Binding Domain (LBD) monomer, 26 kDa Mus musculus protein
...receptor alpha (RXR-alpha) Δ helix12 monomer, 24 kDa Mus musculus protein
Buffer: ...150 mM NaCl, 2 mM TCEP, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on ...14 Jul 23
...Receptor Heterodimer and Its Corepressor Regulates Gene Expression. Structure (2019)
Cordeiro TN, Sibille N, Germain P, Barthe P, Boulahtouf A, Allemand F, Bailly R, Vivat V, Ebel C, Barducci A, Bourguet W, le Maire A, Bernadó P
RgGuinier 4.2 nm
Dmax 15.7 nm
VolumePorod 183 nm3

SASDF64 – ...1:1) with RAR inverse agonist (BMS493)

Nuclear receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID)Retinoid-X receptor alpha (RXR-alpha) Ligand Binding Domain (LBD)Retinoic acid receptor alpha (RAR-alpha) Ligand binding domain (LDB) experimental SAS data
Nuclear receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID) Retinoid-X receptor alpha (RXR-alpha) Ligand Binding Domain (LBD) Retinoic acid receptor alpha (RAR-alpha) Ligand binding domain (LDB) Kratky plot
Sample: Nuclear receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID) monomer, 29 kDa Mus musculus protein
...receptor alpha (RXR-alpha) Ligand Binding Domain (LBD) monomer, 26 kDa Mus musculus protein
...receptor alpha (RAR-alpha) Ligand binding domain (LDB) monomer, 28 kDa Homo sapiens protein
Buffer: ...150 mM NaCl, 2 mM TCEP, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on ...14 Jul 23
...Receptor Heterodimer and Its Corepressor Regulates Gene Expression. Structure (2019)
Cordeiro TN, Sibille N, Germain P, Barthe P, Boulahtouf A, Allemand F, Bailly R, Vivat V, Ebel C, Barducci A, Bourguet W, le Maire A, Bernadó P
RgGuinier 4.8 nm
Dmax 19.5 nm
VolumePorod 178 nm3

SASDF74 – ...1:1)

Nuclear receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID)Retinoid-X receptor alpha (RXR-alpha) Ligand Binding Domain (LBD)Retinoic acid receptor alpha (RAR-alpha) Ligand binding domain (LDB) mutant I396E experimental SAS data
Nuclear receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID) Retinoid-X receptor alpha (RXR-alpha) Ligand Binding Domain (LBD) Retinoic acid receptor alpha (RAR-alpha) Ligand binding domain (LDB) mutant I396E Kratky plot
Sample: Nuclear receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID) monomer, 29 kDa Mus musculus protein
...receptor alpha (RXR-alpha) Ligand Binding Domain (LBD) monomer, 26 kDa Mus musculus protein
...receptor alpha (RAR-alpha) Ligand binding domain (LDB) mutant I396E monomer, 28 kDa Homo sapiens protein
Buffer: ...150 mM NaCl, 2 mM TCEP, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on ...15 Mar 9
...Receptor Heterodimer and Its Corepressor Regulates Gene Expression. Structure (2019)
Cordeiro TN, Sibille N, Germain P, Barthe P, Boulahtouf A, Allemand F, Bailly R, Vivat V, Ebel C, Barducci A, Bourguet W, le Maire A, Bernadó P
RgGuinier 5.3 nm
Dmax 22.4 nm
VolumePorod 171 nm3

SASDF84 – ...1:1) with RAR agonist (Am580)

Nuclear receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID)Retinoid-X receptor alpha (RXR-alpha) Ligand Binding Domain (LBD)Retinoic acid receptor alpha (RAR-alpha) Ligand binding domain (LDB) experimental SAS data
Nuclear receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID) Retinoid-X receptor alpha (RXR-alpha) Ligand Binding Domain (LBD) Retinoic acid receptor alpha (RAR-alpha) Ligand binding domain (LDB) Kratky plot
Sample: Nuclear receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID) monomer, 29 kDa Mus musculus protein
...receptor alpha (RXR-alpha) Ligand Binding Domain (LBD) monomer, 26 kDa Mus musculus protein
...receptor alpha (RAR-alpha) Ligand binding domain (LDB) monomer, 28 kDa Homo sapiens protein
Buffer: ...150 mM NaCl, 2 mM TCEP, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on ...14 Jul 23
...Receptor Heterodimer and Its Corepressor Regulates Gene Expression. Structure (2019)
Cordeiro TN, Sibille N, Germain P, Barthe P, Boulahtouf A, Allemand F, Bailly R, Vivat V, Ebel C, Barducci A, Bourguet W, le Maire A, Bernadó P
RgGuinier 4.2 nm
Dmax 17.2 nm
VolumePorod 131 nm3