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20 hits found for Retinoic acid receptor alpha

SASDXM2 – RAR/RXR heterodimer : BMS493 : DR0 element

Retinoic acid receptor alphaDirect Repeat binding site with zero-base-pair spacingBMS493 (RAR inverse agonist ligand)Retinoid X receptor alpha experimental SAS data
Retinoic acid receptor alpha Direct Repeat binding site with zero-base-pair spacing BMS493 (RAR inverse agonist ligand) Retinoid X receptor alpha Kratky plot
Sample: Retinoic acid receptor alpha monomer, 39 kDa Mus musculus protein
Direct Repeat binding site with zero-base-pair spacing monomer, 10 kDa DNA
BMS493 (RAR inverse agonist ligand) monomer, 0 kDa
...receptor alpha monomer, 38 kDa Homo sapiens protein
Buffer: 20 mM Tris HCl, 75 mM NaCl, 75 mM KCl, 2 mM CHAPS, 4 mM MgCl₂, 12 mM TCEP, pH: 7.5
Experiment: SAXS data collected at SWING, SOLEIL on 2024 Apr 18
...retinoic acid receptors RAR/RXR by DNA, ligands, and transcriptional coregulators. ...Acids Res 53(18) (2025)
Tambones I, Sagar A, Vankova P, Loginov D, Carivenc C, Rochel N, Bourguet W, Man P, Bernadó P, le Maire A
RgGuinier 3.6 nm
Dmax 13.1 nm
VolumePorod 121 nm3

SASDXN2 – RAR/RXR heterodimer : BMS493 : DR0L element

Retinoic acid receptor alphaBMS493 (RAR inverse agonist ligand)Direct Repeat binding site with zero-base-pair spacing (long sequence)Retinoid X receptor alpha experimental SAS data
Retinoic acid receptor alpha BMS493 (RAR inverse agonist ligand) Direct Repeat binding site with zero-base-pair spacing (long sequence) Retinoid X receptor alpha Kratky plot
Sample: Retinoic acid receptor alpha monomer, 39 kDa Mus musculus protein
BMS493 (RAR inverse agonist ligand) monomer, 0 kDa
Direct Repeat binding site with zero-base-pair spacing (long sequence) monomer, 19 kDa DNA
...receptor alpha monomer, 38 kDa Homo sapiens protein
Buffer: 20 mM Tris HCl, 75 mM NaCl, 75 mM KCl, 2 mM CHAPS, 4 mM MgCl₂, 12 mM TCEP, pH: 7.5
Experiment: SAXS data collected at SWING, SOLEIL on 2022 Dec 12
...retinoic acid receptors RAR/RXR by DNA, ligands, and transcriptional coregulators. ...Acids Res 53(18) (2025)
Tambones I, Sagar A, Vankova P, Loginov D, Carivenc C, Rochel N, Bourguet W, Man P, Bernadó P, le Maire A
RgGuinier 4.1 nm
Dmax 14.8 nm
VolumePorod 152 nm3

SASDXP2 – RAR/RXR heterodimer : BMS493 : DR1 element

Retinoic acid receptor alphaBMS493 (RAR inverse agonist ligand)Retinoid X receptor alphaDirect Repeat binding site with one-base-pair spacing experimental SAS data
Retinoic acid receptor alpha BMS493 (RAR inverse agonist ligand) Retinoid X receptor alpha Direct Repeat binding site with one-base-pair spacing Kratky plot
Sample: Retinoic acid receptor alpha monomer, 39 kDa Mus musculus protein
BMS493 (RAR inverse agonist ligand) monomer, 0 kDa
...receptor alpha monomer, 38 kDa Homo sapiens protein
Direct Repeat binding site with one-base-pair spacing monomer, 11 kDa DNA
Buffer: 20 mM Tris HCl, 75 mM NaCl, 75 mM KCl, 2 mM CHAPS, 4 mM MgCl₂, 12 mM TCEP, pH: 7.5
Experiment: SAXS data collected at SWING, SOLEIL on 2022 Apr 20
...retinoic acid receptors RAR/RXR by DNA, ligands, and transcriptional coregulators. ...Acids Res 53(18) (2025)
Tambones I, Sagar A, Vankova P, Loginov D, Carivenc C, Rochel N, Bourguet W, Man P, Bernadó P, le Maire A
RgGuinier 3.8 nm
Dmax 13.9 nm
VolumePorod 120 nm3

SASDXQ2 – RAR/RXR heterodimer : BMS493 : DR5 element

Retinoic acid receptor alphaBMS493 (RAR inverse agonist ligand)Retinoid X receptor alphaDirect Repeat binding site with five-base-pair spacing experimental SAS data
Retinoic acid receptor alpha BMS493 (RAR inverse agonist ligand) Retinoid X receptor alpha Direct Repeat binding site with five-base-pair spacing Kratky plot
Sample: Retinoic acid receptor alpha monomer, 39 kDa Mus musculus protein
BMS493 (RAR inverse agonist ligand) monomer, 0 kDa
...receptor alpha monomer, 38 kDa Homo sapiens protein
Direct Repeat binding site with five-base-pair spacing monomer, 13 kDa DNA
Buffer: 20 mM Tris HCl, 75 mM NaCl, 75 mM KCl, 2 mM CHAPS, 4 mM MgCl₂, 12 mM TCEP, pH: 7.5
Experiment: SAXS data collected at SWING, SOLEIL on 2022 Sep 12
...retinoic acid receptors RAR/RXR by DNA, ligands, and transcriptional coregulators. ...Acids Res 53(18) (2025)
Tambones I, Sagar A, Vankova P, Loginov D, Carivenc C, Rochel N, Bourguet W, Man P, Bernadó P, le Maire A
RgGuinier 3.9 nm
Dmax 14.3 nm
VolumePorod 130 nm3

SASDXR2 – RAR/RXR heterodimer : BMS493 : IR0 element

Retinoic acid receptor alphaBMS493 (RAR inverse agonist ligand)Retinoid X receptor alphaInverted Repeat binding site with zero-base-pair spacing experimental SAS data
Retinoic acid receptor alpha BMS493 (RAR inverse agonist ligand) Retinoid X receptor alpha Inverted Repeat binding site with zero-base-pair spacing Kratky plot
Sample: Retinoic acid receptor alpha monomer, 39 kDa Mus musculus protein
BMS493 (RAR inverse agonist ligand) monomer, 0 kDa
...receptor alpha monomer, 38 kDa Homo sapiens protein
Inverted Repeat binding site with zero-base-pair spacing monomer, 11 kDa DNA
Buffer: 20 mM Tris HCl, 75 mM NaCl, 75 mM KCl, 2 mM CHAPS, 4 mM MgCl₂, 12 mM TCEP, pH: 7.5
Experiment: SAXS data collected at SWING, SOLEIL on 2022 Apr 20
...retinoic acid receptors RAR/RXR by DNA, ligands, and transcriptional coregulators. ...Acids Res 53(18) (2025)
Tambones I, Sagar A, Vankova P, Loginov D, Carivenc C, Rochel N, Bourguet W, Man P, Bernadó P, le Maire A
RgGuinier 3.9 nm
Dmax 12.9 nm
VolumePorod 121 nm3

SASDXS2 – RAR/RXR heterodimer : BMS493 : NCoR NID : DR0L element

Retinoic acid receptor alphaBMS493 (RAR inverse agonist ligand)Direct Repeat binding site with zero-base-pair spacing (long sequence)Retinoid X receptor alphaNuclear receptor corepressor 1 experimental SAS data
Retinoic acid receptor alpha BMS493 (RAR inverse agonist ligand) Direct Repeat binding site with zero-base-pair spacing (long sequence) Retinoid X receptor alpha Nuclear receptor corepressor 1 Kratky plot
Sample: Retinoic acid receptor alpha monomer, 39 kDa Mus musculus protein
BMS493 (RAR inverse agonist ligand) monomer, 0 kDa
Direct Repeat binding site with zero-base-pair spacing (long sequence) monomer, 19 kDa DNA
...receptor alpha monomer, 38 kDa Homo sapiens protein
...receptor corepressor 1 monomer, 29 kDa Mus musculus protein
Buffer: 20 mM Tris HCl, 75 mM NaCl, 75 mM KCl, 2 mM CHAPS, 4 mM MgCl₂, 12 mM TCEP, pH: 7.5
Experiment: SAXS data collected at SWING, SOLEIL on 2022 Dec 12
...retinoic acid receptors RAR/RXR by DNA, ligands, and transcriptional coregulators. ...Acids Res 53(18) (2025)
Tambones I, Sagar A, Vankova P, Loginov D, Carivenc C, Rochel N, Bourguet W, Man P, Bernadó P, le Maire A
RgGuinier 5.4 nm
Dmax 20.1 nm
VolumePorod 363 nm3

SASDXT2 – RAR/RXR heterodimer : BMS493 : NCoR NID : DR1 element

Retinoic acid receptor alphaBMS493 (RAR inverse agonist ligand)Retinoid X receptor alphaDirect Repeat binding site with one-base-pair spacingNuclear receptor corepressor 1 experimental SAS data
Retinoic acid receptor alpha BMS493 (RAR inverse agonist ligand) Retinoid X receptor alpha Direct Repeat binding site with one-base-pair spacing Nuclear receptor corepressor 1 Kratky plot
Sample: Retinoic acid receptor alpha monomer, 39 kDa Mus musculus protein
BMS493 (RAR inverse agonist ligand) monomer, 0 kDa
...receptor alpha monomer, 38 kDa Homo sapiens protein
Direct Repeat binding site with one-base-pair spacing monomer, 11 kDa DNA
...receptor corepressor 1 monomer, 29 kDa Mus musculus protein
Buffer: 20 mM Tris HCl, 75 mM NaCl, 75 mM KCl, 2 mM CHAPS, 4 mM MgCl₂, 12 mM TCEP, pH: 7.5
Experiment: SAXS data collected at SWING, SOLEIL on 2022 Apr 20
...retinoic acid receptors RAR/RXR by DNA, ligands, and transcriptional coregulators. ...Acids Res 53(18) (2025)
Tambones I, Sagar A, Vankova P, Loginov D, Carivenc C, Rochel N, Bourguet W, Man P, Bernadó P, le Maire A
RgGuinier 5.6 nm
Dmax 21.8 nm
VolumePorod 330 nm3

SASDXU2 – RAR/RXR heterodimer : BMS493 : NCoR NID : DR5 element

Retinoic acid receptor alphaBMS493 (RAR inverse agonist ligand)Retinoid X receptor alphaDirect Repeat binding site with five-base-pair spacingNuclear receptor corepressor 1 experimental SAS data
Retinoic acid receptor alpha BMS493 (RAR inverse agonist ligand) Retinoid X receptor alpha Direct Repeat binding site with five-base-pair spacing Nuclear receptor corepressor 1 Kratky plot
Sample: Retinoic acid receptor alpha monomer, 39 kDa Mus musculus protein
BMS493 (RAR inverse agonist ligand) monomer, 0 kDa
...receptor alpha monomer, 38 kDa Homo sapiens protein
Direct Repeat binding site with five-base-pair spacing monomer, 13 kDa DNA
...receptor corepressor 1 monomer, 29 kDa Mus musculus protein
Buffer: 20 mM Tris HCl, 75 mM NaCl, 75 mM KCl, 2 mM CHAPS, 4 mM MgCl₂, 12 mM TCEP, pH: 7.5
Experiment: SAXS data collected at SWING, SOLEIL on 2022 Dec 12
...retinoic acid receptors RAR/RXR by DNA, ligands, and transcriptional coregulators. ...Acids Res 53(18) (2025)
Tambones I, Sagar A, Vankova P, Loginov D, Carivenc C, Rochel N, Bourguet W, Man P, Bernadó P, le Maire A
RgGuinier 5.7 nm
Dmax 21.8 nm
VolumePorod 363 nm3

SASDXV2 – RAR/RXR heterodimer : BMS493 : NCoR NID : IR0 element

Retinoic acid receptor alphaBMS493 (RAR inverse agonist ligand)Retinoid X receptor alphaInverted Repeat binding site with zero-base-pair spacingNuclear receptor corepressor 1 experimental SAS data
Retinoic acid receptor alpha BMS493 (RAR inverse agonist ligand) Retinoid X receptor alpha Inverted Repeat binding site with zero-base-pair spacing Nuclear receptor corepressor 1 Kratky plot
Sample: Retinoic acid receptor alpha monomer, 39 kDa Mus musculus protein
BMS493 (RAR inverse agonist ligand) monomer, 0 kDa
...receptor alpha monomer, 38 kDa Homo sapiens protein
Inverted Repeat binding site with zero-base-pair spacing monomer, 11 kDa DNA
...receptor corepressor 1 monomer, 29 kDa Mus musculus protein
Buffer: 20 mM Tris HCl, 75 mM NaCl, 75 mM KCl, 2 mM CHAPS, 4 mM MgCl₂, 12 mM TCEP, pH: 7.5
Experiment: SAXS data collected at SWING, SOLEIL on 2022 Apr 20
...retinoic acid receptors RAR/RXR by DNA, ligands, and transcriptional coregulators. ...Acids Res 53(18) (2025)
Tambones I, Sagar A, Vankova P, Loginov D, Carivenc C, Rochel N, Bourguet W, Man P, Bernadó P, le Maire A
RgGuinier 5.5 nm
Dmax 22.9 nm
VolumePorod 257 nm3

SASDF44 – RXR/RAR Heterodimer : N-CoRNID Complex (1:1)

Nuclear receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID)Retinoid-X receptor alpha (RXR-alpha) Ligand Binding Domain (LBD)Retinoic acid receptor alpha (RAR-alpha) Ligand binding domain (LDB) experimental SAS data
Nuclear receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID) Retinoid-X receptor alpha (RXR-alpha) Ligand Binding Domain (LBD) Retinoic acid receptor alpha (RAR-alpha) Ligand binding domain (LDB) Kratky plot
Sample: ...receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID) monomer, 29 kDa Mus musculus protein
...receptor alpha (RXR-alpha) Ligand Binding Domain (LBD) monomer, 26 kDa Mus musculus protein
Retinoic acid receptor alpha (RAR-alpha) Ligand binding domain (LDB) monomer, 28 kDa Homo sapiens protein
Buffer: 50 mM Tris-HCl, 150 mM NaCl, 2 mM TCEP, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2014 Jul 23
...Retinoic Acid Receptor Heterodimer and Its Corepressor Regulates Gene Expression. Structure (2019)
Cordeiro TN, Sibille N, Germain P, Barthe P, Boulahtouf A, Allemand F, Bailly R, Vivat V, Ebel C, Barducci A, Bourguet W, le Maire A, Bernadó P
RgGuinier 4.8 nm
Dmax 19.4 nm
VolumePorod 167 nm3

SASDF64 – RXR/RAR Heterodimer : N-CoRNID Complex (1:1) with RAR inverse agonist (BMS493)

Nuclear receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID)Retinoid-X receptor alpha (RXR-alpha) Ligand Binding Domain (LBD)Retinoic acid receptor alpha (RAR-alpha) Ligand binding domain (LDB) experimental SAS data
Nuclear receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID) Retinoid-X receptor alpha (RXR-alpha) Ligand Binding Domain (LBD) Retinoic acid receptor alpha (RAR-alpha) Ligand binding domain (LDB) Kratky plot
Sample: ...receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID) monomer, 29 kDa Mus musculus protein
...receptor alpha (RXR-alpha) Ligand Binding Domain (LBD) monomer, 26 kDa Mus musculus protein
Retinoic acid receptor alpha (RAR-alpha) Ligand binding domain (LDB) monomer, 28 kDa Homo sapiens protein
Buffer: 50 mM Tris-HCl, 150 mM NaCl, 2 mM TCEP, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2014 Jul 23
...Retinoic Acid Receptor Heterodimer and Its Corepressor Regulates Gene Expression. Structure (2019)
Cordeiro TN, Sibille N, Germain P, Barthe P, Boulahtouf A, Allemand F, Bailly R, Vivat V, Ebel C, Barducci A, Bourguet W, le Maire A, Bernadó P
RgGuinier 4.8 nm
Dmax 19.5 nm
VolumePorod 178 nm3

SASDF74 – RXR/RARI396E Heterodimer : N-CoRNID Complex (1:1)

Nuclear receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID)Retinoid-X receptor alpha (RXR-alpha) Ligand Binding Domain (LBD)Retinoic acid receptor alpha (RAR-alpha) Ligand binding domain (LDB) mutant I396E experimental SAS data
Nuclear receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID) Retinoid-X receptor alpha (RXR-alpha) Ligand Binding Domain (LBD) Retinoic acid receptor alpha (RAR-alpha) Ligand binding domain (LDB) mutant I396E Kratky plot
Sample: ...receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID) monomer, 29 kDa Mus musculus protein
...receptor alpha (RXR-alpha) Ligand Binding Domain (LBD) monomer, 26 kDa Mus musculus protein
Retinoic acid receptor alpha (RAR-alpha) Ligand binding domain (LDB) mutant I396E monomer, 28 kDa Homo sapiens protein
Buffer: 50 mM Tris-HCl, 150 mM NaCl, 2 mM TCEP, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2015 Mar 9
...Retinoic Acid Receptor Heterodimer and Its Corepressor Regulates Gene Expression. Structure (2019)
Cordeiro TN, Sibille N, Germain P, Barthe P, Boulahtouf A, Allemand F, Bailly R, Vivat V, Ebel C, Barducci A, Bourguet W, le Maire A, Bernadó P
RgGuinier 5.3 nm
Dmax 22.4 nm
VolumePorod 171 nm3

SASDF84 – RXR/RAR Heterodimer : N-CoRNID Complex (1:1) with RAR agonist (Am580)

Nuclear receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID)Retinoid-X receptor alpha (RXR-alpha) Ligand Binding Domain (LBD)Retinoic acid receptor alpha (RAR-alpha) Ligand binding domain (LDB) experimental SAS data
Nuclear receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID) Retinoid-X receptor alpha (RXR-alpha) Ligand Binding Domain (LBD) Retinoic acid receptor alpha (RAR-alpha) Ligand binding domain (LDB) Kratky plot
Sample: ...receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID) monomer, 29 kDa Mus musculus protein
...receptor alpha (RXR-alpha) Ligand Binding Domain (LBD) monomer, 26 kDa Mus musculus protein
Retinoic acid receptor alpha (RAR-alpha) Ligand binding domain (LDB) monomer, 28 kDa Homo sapiens protein
Buffer: 50 mM Tris-HCl, 150 mM NaCl, 2 mM TCEP, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2014 Jul 23
...Retinoic Acid Receptor Heterodimer and Its Corepressor Regulates Gene Expression. Structure (2019)
Cordeiro TN, Sibille N, Germain P, Barthe P, Boulahtouf A, Allemand F, Bailly R, Vivat V, Ebel C, Barducci A, Bourguet W, le Maire A, Bernadó P
RgGuinier 4.2 nm
Dmax 17.2 nm
VolumePorod 131 nm3

SASDMU4 – Retinoic acid receptor RXR-alpha ligand binding domain (LBD)

Retinoic acid receptor RXR-alpha experimental SAS data
CUSTOM IN-HOUSE model
Sample: Retinoic acid receptor RXR-alpha dimer, 51 kDa Homo sapiens protein
Buffer: 20 mM Tris, 100 mM NaCl, 100 mM KCl, 5% glycerol, 2 mM Chaps, and 5 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL X33, DORIS III, DESY on 2010 Oct 7
...Receptor α in the Context of the Full-Length Protein Biochemistry 55(12):1741-1748 (2016)
Belorusova A, Osz J, Petoukhov M, Peluso-Iltis C, Kieffer B, Svergun D, Rochel N
RgGuinier 2.5 nm
Dmax 8.3 nm
VolumePorod 60 nm3

SASDMV4 – ...Retinoic acid receptor RXR-alpha in complex with Ramp2 DNA

Retinoic acid receptor RXR-alphaRamp2 DNA experimental SAS data
EOM/RANCH model
Sample: Retinoic acid receptor RXR-alpha dimer, 102 kDa Homo sapiens protein
Ramp2 DNA monomer, 11 kDa DNA
Buffer: 20 mM Tris, 50 mM NaCl, 50 mM KCl, 5% glycerol, 2 mM Chaps, and 5 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL X33, DORIS III, DESY on 2010 May 7
...Receptor α in the Context of the Full-Length Protein Biochemistry 55(12):1741-1748 (2016)
Belorusova A, Osz J, Petoukhov M, Peluso-Iltis C, Kieffer B, Svergun D, Rochel N
RgGuinier 4.4 nm
Dmax 13.9 nm
VolumePorod 161 nm3

SASDMW4 – Retinoic acid receptor RXR-alpha N-terminal and DNA binding domains (DBD) in complex with Ramp2 DNA

Ramp2 DNARetinoic acid receptor RXR-alpha experimental SAS data
EOM/RANCH model
Sample: Ramp2 DNA monomer, 11 kDa DNA
Retinoic acid receptor RXR-alpha dimer, 44 kDa Homo sapiens protein
Buffer: 20 mM Tris, 50 mM NaCl, 50 mM KCl, 5% glycerol, 2 mM Chaps, and 5 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL X33, DORIS III, DESY on 2009 Jul 17
...Receptor α in the Context of the Full-Length Protein Biochemistry 55(12):1741-1748 (2016)
Belorusova A, Osz J, Petoukhov M, Peluso-Iltis C, Kieffer B, Svergun D, Rochel N
RgGuinier 4.3 nm
Dmax 14.3 nm
VolumePorod 89 nm3

SASDMX4 – Retinoic acid receptor RXR-alpha DNA binding (DBD) and ligand binding (LBD) domains in complex with Ramp2 DNA

Ramp2 DNARetinoic acid receptor RXR-alpha experimental SAS data
CORAL model
Sample: Ramp2 DNA monomer, 11 kDa DNA
Retinoic acid receptor RXR-alpha dimer, 74 kDa Homo sapiens protein
Buffer: 20 mM Tris, 50 mM NaCl, 50 mM KCl, 5% glycerol, 2 mM Chaps, and 5 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL X33, DORIS III, DESY on 2010 Oct 7
...Receptor α in the Context of the Full-Length Protein Biochemistry 55(12):1741-1748 (2016)
Belorusova A, Osz J, Petoukhov M, Peluso-Iltis C, Kieffer B, Svergun D, Rochel N
RgGuinier 3.6 nm
Dmax 12.2 nm

SASDMY4 – Retinoic acid receptor RXR-alpha DNA binding domain (DBD) in complex with Ramp2

Ramp2 DNARetinoic acid receptor RXR-alpha experimental SAS data
CUSTOM IN-HOUSE model
Sample: Ramp2 DNA monomer, 11 kDa DNA
Retinoic acid receptor RXR-alpha dimer, 20 kDa Homo sapiens protein
Buffer: 20 mM Tris, 50 mM NaCl, 50 mM KCl, 5% glycerol, 2 mM Chaps, and 5 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL X33, DORIS III, DESY on 2010 Oct 7
...Receptor α in the Context of the Full-Length Protein Biochemistry 55(12):1741-1748 (2016)
Belorusova A, Osz J, Petoukhov M, Peluso-Iltis C, Kieffer B, Svergun D, Rochel N
RgGuinier 1.9 nm
Dmax 5.8 nm

SASDFT8 – ...retinoic acid receptor (RAR-RXR heterodimer) bound to the DNA response element HoxB13 DR0

Retinoic acid receptor alpha, RARRetinoic acid receptor RXR-alphaDNA response element HoxB13 DR0 experimental SAS data
CORAL model
Sample: Retinoic acid receptor alpha, RAR monomer, 41 kDa Mus musculus protein
Retinoic acid receptor RXR-alpha monomer, 38 kDa Mus musculus protein
DNA response element HoxB13 DR0 monomer, 10 kDa DNA
Buffer: 20 mM Tris, pH 8, 150 mM NaCl, 5% v/v glycerol, 1 mM CHAPS, 4 mM MgSO4, 1 mM TCEP, pH: 8
Experiment: SAXS data collected at EMBL P12, PETRA III on 2014 Jan 19
...retinoic acid receptors RAR–RXR ...Acids Research (2020)
Osz J, McEwen A, Bourguet M, Przybilla F, Peluso-Iltis C, Poussin-Courmontagne P, Mély Y, Cianférani S, Jeffries C, Svergun D, Rochel N
RgGuinier 3.8 nm
Dmax 14.5 nm
VolumePorod 132 nm3

SASDFU8 – ...retinoic acid receptor (RAR-RXR heterodimer) bound to the DNA response element F11r DR5.

Retinoic acid receptor alpha, RARRetinoic acid receptor RXR-alphaDNA response element F11r DR5 experimental SAS data
CORAL model
Sample: Retinoic acid receptor alpha, RAR monomer, 41 kDa Mus musculus protein
Retinoic acid receptor RXR-alpha monomer, 38 kDa Mus musculus protein
DNA response element F11r DR5 monomer, 13 kDa DNA
Buffer: 20 mM Tris, pH 8, 150 mM NaCl, 5% v/v glycerol, 1 mM CHAPS, 4 mM MgSO4, 1 mM TCEP, pH: 8
Experiment: SAXS data collected at EMBL P12, PETRA III on 2014 Jan 19
...retinoic acid receptors RAR–RXR ...Acids Research (2020)
Osz J, McEwen A, Bourguet M, Przybilla F, Peluso-Iltis C, Poussin-Courmontagne P, Mély Y, Cianférani S, Jeffries C, Svergun D, Rochel N
RgGuinier 4.0 nm
Dmax 13.5 nm
VolumePorod 130 nm3