Small Angle Scattering Biological Data Bank SASBDB


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14 hits found for Retinoid X receptor alpha

...XM2 – ...XR heterodimer : BMS493 : DR0 element

Retinoic acid receptor alphaDirect Repeat binding site with zero-base-pair spacingBMS493 (RAR inverse agonist ligand)Retinoid X receptor alpha experimental SAS data

Sample:	...receptor alpha monomer, 39 kDa Mus musculus protein Direct Repeat binding site with zero-base-pair spacing monomer, 10 kDa DNA BMS493 (RAR inverse agonist ligand) monomer, 0 kDa Retinoid X receptor alpha monomer, 38 kDa Homo sapiens protein
Buffer:	20 mM Tris HCl, 75 mM NaCl, 75 mM KCl, 2 mM CHAPS, 4 mM MgCl₂, 12 mM TCEP, pH: 7.5
Experiment:	...XS data collected at SWING, SOLEIL on 2024 Apr 18

...receptors RAR/RXR by DNA, ligands, and transcriptional coregulators. Nucleic Acids Res 53(18) (2025)
Tambones I, Sagar A, Vankova P, Loginov D, Carivenc C, Rochel N, Bourguet W, Man P, Bernadó P, le Maire A

R_g^Guinier	3.6	nm
D_max	13.1	nm
Volume^Porod	121	nm³

...XN2 – ...XR heterodimer : BMS493 : DR0L element

Retinoic acid receptor alphaBMS493 (RAR inverse agonist ligand)Direct Repeat binding site with zero-base-pair spacing (long sequence)Retinoid X receptor alpha experimental SAS data

Sample:	...receptor alpha monomer, 39 kDa Mus musculus protein BMS493 (RAR inverse agonist ligand) monomer, 0 kDa Direct Repeat binding site with zero-base-pair spacing (long sequence) monomer, 19 kDa DNA Retinoid X receptor alpha monomer, 38 kDa Homo sapiens protein
Buffer:	20 mM Tris HCl, 75 mM NaCl, 75 mM KCl, 2 mM CHAPS, 4 mM MgCl₂, 12 mM TCEP, pH: 7.5
Experiment:	...XS data collected at SWING, SOLEIL on 2022 Dec 12

R_g^Guinier	4.1	nm
D_max	14.8	nm
Volume^Porod	152	nm³

...XP2 – ...XR heterodimer : BMS493 : DR1 element

Retinoic acid receptor alphaBMS493 (RAR inverse agonist ligand)Retinoid X receptor alphaDirect Repeat binding site with one-base-pair spacing experimental SAS data

Sample:	...receptor alpha monomer, 39 kDa Mus musculus protein BMS493 (RAR inverse agonist ligand) monomer, 0 kDa Retinoid X receptor alpha monomer, 38 kDa Homo sapiens protein Direct Repeat binding site with one-base-pair spacing monomer, 11 kDa DNA
Buffer:	20 mM Tris HCl, 75 mM NaCl, 75 mM KCl, 2 mM CHAPS, 4 mM MgCl₂, 12 mM TCEP, pH: 7.5
Experiment:	...XS data collected at SWING, SOLEIL on 2022 Apr 20

R_g^Guinier	3.8	nm
D_max	13.9	nm
Volume^Porod	120	nm³

...XQ2 – ...XR heterodimer : BMS493 : DR5 element

Retinoic acid receptor alphaBMS493 (RAR inverse agonist ligand)Retinoid X receptor alphaDirect Repeat binding site with five-base-pair spacing experimental SAS data

Sample:	...receptor alpha monomer, 39 kDa Mus musculus protein BMS493 (RAR inverse agonist ligand) monomer, 0 kDa Retinoid X receptor alpha monomer, 38 kDa Homo sapiens protein Direct Repeat binding site with five-base-pair spacing monomer, 13 kDa DNA
Buffer:	20 mM Tris HCl, 75 mM NaCl, 75 mM KCl, 2 mM CHAPS, 4 mM MgCl₂, 12 mM TCEP, pH: 7.5
Experiment:	...XS data collected at SWING, SOLEIL on 2022 Sep 12

R_g^Guinier	3.9	nm
D_max	14.3	nm
Volume^Porod	130	nm³

...XR2 – ...XR heterodimer : BMS493 : IR0 element

Retinoic acid receptor alphaBMS493 (RAR inverse agonist ligand)Retinoid X receptor alphaInverted Repeat binding site with zero-base-pair spacing experimental SAS data

Sample:	...receptor alpha monomer, 39 kDa Mus musculus protein BMS493 (RAR inverse agonist ligand) monomer, 0 kDa Retinoid X receptor alpha monomer, 38 kDa Homo sapiens protein Inverted Repeat binding site with zero-base-pair spacing monomer, 11 kDa DNA
Buffer:	20 mM Tris HCl, 75 mM NaCl, 75 mM KCl, 2 mM CHAPS, 4 mM MgCl₂, 12 mM TCEP, pH: 7.5
Experiment:	...XS data collected at SWING, SOLEIL on 2022 Apr 20

R_g^Guinier	3.9	nm
D_max	12.9	nm
Volume^Porod	121	nm³

...XS2 – ...XR heterodimer : BMS493 : NCoR NID : DR0L element

Sample:	...receptor alpha monomer, 39 kDa Mus musculus protein BMS493 (RAR inverse agonist ligand) monomer, 0 kDa Direct Repeat binding site with zero-base-pair spacing (long sequence) monomer, 19 kDa DNA Retinoid X receptor alpha monomer, 38 kDa Homo sapiens protein ...receptor corepressor 1 monomer, 29 kDa Mus musculus protein
Buffer:	20 mM Tris HCl, 75 mM NaCl, 75 mM KCl, 2 mM CHAPS, 4 mM MgCl₂, 12 mM TCEP, pH: 7.5
Experiment:	...XS data collected at SWING, SOLEIL on 2022 Dec 12

R_g^Guinier	5.4	nm
D_max	20.1	nm
Volume^Porod	363	nm³

...XT2 – ...XR heterodimer : BMS493 : NCoR NID : DR1 element

Sample:	...receptor alpha monomer, 39 kDa Mus musculus protein BMS493 (RAR inverse agonist ligand) monomer, 0 kDa Retinoid X receptor alpha monomer, 38 kDa Homo sapiens protein Direct Repeat binding site with one-base-pair spacing monomer, 11 kDa DNA ...receptor corepressor 1 monomer, 29 kDa Mus musculus protein
Buffer:	20 mM Tris HCl, 75 mM NaCl, 75 mM KCl, 2 mM CHAPS, 4 mM MgCl₂, 12 mM TCEP, pH: 7.5
Experiment:	...XS data collected at SWING, SOLEIL on 2022 Apr 20

R_g^Guinier	5.6	nm
D_max	21.8	nm
Volume^Porod	330	nm³

...XU2 – ...XR heterodimer : BMS493 : NCoR NID : DR5 element

Sample:	...receptor alpha monomer, 39 kDa Mus musculus protein BMS493 (RAR inverse agonist ligand) monomer, 0 kDa Retinoid X receptor alpha monomer, 38 kDa Homo sapiens protein Direct Repeat binding site with five-base-pair spacing monomer, 13 kDa DNA ...receptor corepressor 1 monomer, 29 kDa Mus musculus protein
Buffer:	20 mM Tris HCl, 75 mM NaCl, 75 mM KCl, 2 mM CHAPS, 4 mM MgCl₂, 12 mM TCEP, pH: 7.5
Experiment:	...XS data collected at SWING, SOLEIL on 2022 Dec 12

R_g^Guinier	5.7	nm
D_max	21.8	nm
Volume^Porod	363	nm³

...XV2 – ...XR heterodimer : BMS493 : NCoR NID : IR0 element

Sample:	...receptor alpha monomer, 39 kDa Mus musculus protein BMS493 (RAR inverse agonist ligand) monomer, 0 kDa Retinoid X receptor alpha monomer, 38 kDa Homo sapiens protein Inverted Repeat binding site with zero-base-pair spacing monomer, 11 kDa DNA ...receptor corepressor 1 monomer, 29 kDa Mus musculus protein
Buffer:	20 mM Tris HCl, 75 mM NaCl, 75 mM KCl, 2 mM CHAPS, 4 mM MgCl₂, 12 mM TCEP, pH: 7.5
Experiment:	...XS data collected at SWING, SOLEIL on 2022 Apr 20

R_g^Guinier	5.5	nm
D_max	22.9	nm
Volume^Porod	257	nm³

SASDF44 – ...XR/RAR Heterodimer : N-CoRNID Complex (1:1)

Nuclear receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID)Retinoid-X receptor alpha (RXR-alpha) Ligand Binding Domain (LBD)Retinoic acid receptor alpha (RAR-alpha) Ligand binding domain (LDB) experimental SAS data

Sample:	...receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID) monomer, 29 kDa Mus musculus protein Retinoid-X receptor alpha (RXR-alpha) Ligand Binding Domain (LBD) monomer, 26 kDa Mus musculus protein ...receptor alpha (RAR-alpha) Ligand binding domain (LDB) monomer, 28 kDa Homo sapiens protein
Buffer:	50 mM Tris-HCl, 150 mM NaCl, 2 mM TCEP, pH: 7.5
Experiment:	...XS data collected at BM29, ESRF on 2014 Jul 23

...Receptor Heterodimer and Its Corepressor Regulates Gene Expression. Structure (2019)
Cordeiro TN, Sibille N, Germain P, Barthe P, Boulahtouf A, Allemand F, Bailly R, Vivat V, Ebel C, Barducci A, Bourguet W, le Maire A, Bernadó P

R_g^Guinier	4.8	nm
D_max	19.4	nm
Volume^Porod	167	nm³

SASDF54 – ...XRΔH12/RAR Heterodimer : N-CoRNID Complex (1:1)

Sample:	...receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID) monomer, 29 kDa Mus musculus protein Retinoid-X receptor alpha (RXR-alpha) Ligand Binding Domain (LBD) monomer, 26 kDa Mus musculus protein Retinoid-X receptor alpha (RXR-alpha) Δ helix12 monomer, 24 kDa Mus musculus protein
Buffer:	50 mM Tris-HCl, 150 mM NaCl, 2 mM TCEP, pH: 7.5
Experiment:	...XS data collected at BM29, ESRF on 2014 Jul 23

R_g^Guinier	4.2	nm
D_max	15.7	nm
Volume^Porod	183	nm³

SASDF64 – ...XR/RAR Heterodimer : N-CoRNID Complex (1:1) with RAR inverse agonist (BMS493)

Sample:	...receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID) monomer, 29 kDa Mus musculus protein Retinoid-X receptor alpha (RXR-alpha) Ligand Binding Domain (LBD) monomer, 26 kDa Mus musculus protein ...receptor alpha (RAR-alpha) Ligand binding domain (LDB) monomer, 28 kDa Homo sapiens protein
Buffer:	50 mM Tris-HCl, 150 mM NaCl, 2 mM TCEP, pH: 7.5
Experiment:	...XS data collected at BM29, ESRF on 2014 Jul 23

R_g^Guinier	4.8	nm
D_max	19.5	nm
Volume^Porod	178	nm³

SASDF74 – ...XR/RARI396E Heterodimer : N-CoRNID Complex (1:1)

Sample:	...receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID) monomer, 29 kDa Mus musculus protein Retinoid-X receptor alpha (RXR-alpha) Ligand Binding Domain (LBD) monomer, 26 kDa Mus musculus protein ...receptor alpha (RAR-alpha) Ligand binding domain (LDB) mutant I396E monomer, 28 kDa Homo sapiens protein
Buffer:	50 mM Tris-HCl, 150 mM NaCl, 2 mM TCEP, pH: 7.5
Experiment:	...XS data collected at BM29, ESRF on 2015 Mar 9

R_g^Guinier	5.3	nm
D_max	22.4	nm
Volume^Porod	171	nm³

SASDF84 – ...XR/RAR Heterodimer : N-CoRNID Complex (1:1) with RAR agonist (Am580)

Sample:	...receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID) monomer, 29 kDa Mus musculus protein Retinoid-X receptor alpha (RXR-alpha) Ligand Binding Domain (LBD) monomer, 26 kDa Mus musculus protein ...receptor alpha (RAR-alpha) Ligand binding domain (LDB) monomer, 28 kDa Homo sapiens protein
Buffer:	50 mM Tris-HCl, 150 mM NaCl, 2 mM TCEP, pH: 7.5
Experiment:	...XS data collected at BM29, ESRF on 2014 Jul 23

R_g^Guinier	4.2	nm
D_max	17.2	nm
Volume^Porod	131	nm³

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