SASBDB entries for UniProt ID: O60341

SASDH45 – Histone Deacetylase 1 (HDAC1) and Lysine-specific Demethylase 1 (LSD1) in the complex with CoREST

UniProt ID: Q13547 (1-482) Histone deacetylase 1

UniProt ID: O60341 (1-852) Lysine-specific histone demethylase 1A

UniProt ID: Q9UKL0 (86-485) REST corepressor 1

Histone deacetylase 1Lysine-specific histone demethylase 1AREST corepressor 1 experimental SAS data
DAMFILT model
Sample: Histone deacetylase 1 monomer, 55 kDa Homo sapiens protein
Lysine-specific histone demethylase 1A monomer, 93 kDa Homo sapiens protein
REST corepressor 1 monomer, 46 kDa Homo sapiens protein
Buffer: 25 mM Tris/Cl, 50 mM potassium acetate and 0.5 mM TCEP, pH: 7.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2015 Jan 23
Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex. Cell Rep 30(8):2699-2711.e8 (2020)
Song Y, Dagil L, Fairall L, Robertson N, Wu M, Ragan TJ, Savva CG, Saleh A, Morone N, Kunze MBA, Jamieson AG, Cole PA, Hansen DF, Schwabe JWR
RgGuinier 6.0 nm
Dmax 15.8 nm
VolumePorod 437 nm3