SASBDB entries for UniProt ID: P35609

SASDZN5 – ACTN2-R93Q using SEC-SAXS (dimer peak)

UniProt ID: P35609 (None-None) Alpha-actinin-2
Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
Comprehensive biophysical and structural profiling of alpha-actinin-2 variants reveals mechanistic diversity in hypertrophic cardiomyopathy. Nat Commun 17(1) (2026)
Noureddine M, Mikolajek H, Cowieson N, Pinotsis N, Robinson P, Slater A, Redwood C, Loughna S, Denning C, Mohammed F, Gehmlich K
RgGuinier 11.6 nm
Dmax 37.0 nm

SASDZP5 – ACTN2-R93Q using SEC-SAXS (aggregate peak)

UniProt ID: P35609 (None-None) Alpha-actinin-2
Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
Comprehensive biophysical and structural profiling of alpha-actinin-2 variants reveals mechanistic diversity in hypertrophic cardiomyopathy. Nat Commun 17(1) (2026)
Noureddine M, Mikolajek H, Cowieson N, Pinotsis N, Robinson P, Slater A, Redwood C, Loughna S, Denning C, Mohammed F, Gehmlich K
RgGuinier 12.9 nm
Dmax 57.0 nm

SASDZQ5 – ACTN2-M92V using SEC-SAXS (dimer peak)

UniProt ID: P35609 (None-None) Alpha-actinin-2
Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
Comprehensive biophysical and structural profiling of alpha-actinin-2 variants reveals mechanistic diversity in hypertrophic cardiomyopathy. Nat Commun 17(1) (2026)
Noureddine M, Mikolajek H, Cowieson N, Pinotsis N, Robinson P, Slater A, Redwood C, Loughna S, Denning C, Mohammed F, Gehmlich K
RgGuinier 11.5 nm
Dmax 36.1 nm

SASDZR5 – Alpha-actinin-2 (ACTN2) M92V variant, SEC-SAXS (aggregate peak)

UniProt ID: P35609 (None-None) Alpha-actinin-2
Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
Comprehensive biophysical and structural profiling of alpha-actinin-2 variants reveals mechanistic diversity in hypertrophic cardiomyopathy. Nat Commun 17(1) (2026)
Noureddine M, Mikolajek H, Cowieson N, Pinotsis N, Robinson P, Slater A, Redwood C, Loughna S, Denning C, Mohammed F, Gehmlich K
RgGuinier 11.6 nm
Dmax 49.0 nm