SASBDB entries for UniProt ID: P35609

SASDZC5 – ACTN2-R457C using SEC-SAXS (dimer peak)

UniProt ID: P35609 (None-None) Alpha-actinin-2

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
Comprehensive biophysical and structural profiling of alpha-actinin-2 variants reveals mechanistic diversity in hypertrophic cardiomyopathy. Nat Commun 17(1) (2026)
Noureddine M, Mikolajek H, Cowieson N, Pinotsis N, Robinson P, Slater A, Redwood C, Loughna S, Denning C, Mohammed F, Gehmlich K
RgGuinier 11.1 nm
Dmax 37.0 nm

SASDZD5 – ACTN2-E448A using SEC-SAXS (dimer peak)

UniProt ID: P35609 (None-None) Alpha-actinin-2

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
Comprehensive biophysical and structural profiling of alpha-actinin-2 variants reveals mechanistic diversity in hypertrophic cardiomyopathy. Nat Commun 17(1) (2026)
Noureddine M, Mikolajek H, Cowieson N, Pinotsis N, Robinson P, Slater A, Redwood C, Loughna S, Denning C, Mohammed F, Gehmlich K
RgGuinier 11.8 nm
Dmax 36.5 nm

SASDZE5 – ACTN2-R457C using SEC-SAXS (aggregate peak)

UniProt ID: P35609 (None-None) Alpha-actinin-2

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
Comprehensive biophysical and structural profiling of alpha-actinin-2 variants reveals mechanistic diversity in hypertrophic cardiomyopathy. Nat Commun 17(1) (2026)
Noureddine M, Mikolajek H, Cowieson N, Pinotsis N, Robinson P, Slater A, Redwood C, Loughna S, Denning C, Mohammed F, Gehmlich K
RgGuinier 12.8 nm
Dmax 49.9 nm

SASDZF5 – ACTN2-E448A using SEC-SAXS (aggregate peak)

UniProt ID: P35609 (None-None) Alpha-actinin-2

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
Comprehensive biophysical and structural profiling of alpha-actinin-2 variants reveals mechanistic diversity in hypertrophic cardiomyopathy. Nat Commun 17(1) (2026)
Noureddine M, Mikolajek H, Cowieson N, Pinotsis N, Robinson P, Slater A, Redwood C, Loughna S, Denning C, Mohammed F, Gehmlich K
RgGuinier 13.9 nm
Dmax 48.1 nm

SASDZG5 – ACTN2-R327C using SEC-SAXS (dimer peak)

UniProt ID: P35609 (None-None) Alpha-actinin-2

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
Comprehensive biophysical and structural profiling of alpha-actinin-2 variants reveals mechanistic diversity in hypertrophic cardiomyopathy. Nat Commun 17(1) (2026)
Noureddine M, Mikolajek H, Cowieson N, Pinotsis N, Robinson P, Slater A, Redwood C, Loughna S, Denning C, Mohammed F, Gehmlich K
RgGuinier 10.8 nm
Dmax 36.1 nm

SASDZH5 – ACTN2-R327C using SEC-SAXS (aggregate peak)

UniProt ID: P35609 (None-None) Alpha-actinin-2

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
Comprehensive biophysical and structural profiling of alpha-actinin-2 variants reveals mechanistic diversity in hypertrophic cardiomyopathy. Nat Commun 17(1) (2026)
Noureddine M, Mikolajek H, Cowieson N, Pinotsis N, Robinson P, Slater A, Redwood C, Loughna S, Denning C, Mohammed F, Gehmlich K
RgGuinier 12.8 nm
Dmax 49.1 nm

SASDZJ5 – ACTN2-T247M using SEC-SAXS (dimer peak)

UniProt ID: P35609 (None-None) Alpha-actinin-2

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
Comprehensive biophysical and structural profiling of alpha-actinin-2 variants reveals mechanistic diversity in hypertrophic cardiomyopathy. Nat Commun 17(1) (2026)
Noureddine M, Mikolajek H, Cowieson N, Pinotsis N, Robinson P, Slater A, Redwood C, Loughna S, Denning C, Mohammed F, Gehmlich K
RgGuinier 11.6 nm
Dmax 37.0 nm

SASDZK5 – ACTN2-T247M using SEC-SAXS (aggregate peak)

UniProt ID: P35609 (None-None) Alpha-actinin-2

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
Comprehensive biophysical and structural profiling of alpha-actinin-2 variants reveals mechanistic diversity in hypertrophic cardiomyopathy. Nat Commun 17(1) (2026)
Noureddine M, Mikolajek H, Cowieson N, Pinotsis N, Robinson P, Slater A, Redwood C, Loughna S, Denning C, Mohammed F, Gehmlich K
RgGuinier 16.1 nm
Dmax 78.0 nm

SASDZL5 – ACTN2-G111V using SEC-SAXS (dimer peak)

UniProt ID: P35609 (None-None) Alpha-actinin-2

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
Comprehensive biophysical and structural profiling of alpha-actinin-2 variants reveals mechanistic diversity in hypertrophic cardiomyopathy. Nat Commun 17(1) (2026)
Noureddine M, Mikolajek H, Cowieson N, Pinotsis N, Robinson P, Slater A, Redwood C, Loughna S, Denning C, Mohammed F, Gehmlich K
RgGuinier 10.4 nm
Dmax 37.0 nm

SASDZM5 – ACTN2-G111V using SEC-SAXS (aggregate peak)

UniProt ID: P35609 (None-None) Alpha-actinin-2

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
Comprehensive biophysical and structural profiling of alpha-actinin-2 variants reveals mechanistic diversity in hypertrophic cardiomyopathy. Nat Commun 17(1) (2026)
Noureddine M, Mikolajek H, Cowieson N, Pinotsis N, Robinson P, Slater A, Redwood C, Loughna S, Denning C, Mohammed F, Gehmlich K
RgGuinier 13.0 nm
Dmax 55.5 nm