SASBDB entries for UniProt ID: Q15796

SASDG35 – Mothers against decapentaplegic homolog 2, S2MH1E3

UniProt ID: Q15796 (10-174) Mothers against decapentaplegic homolog 2
Mothers against decapentaplegic homolog 2 experimental SAS data
Mothers against decapentaplegic homolog 2 Kratky plot
Sample: Mothers against decapentaplegic homolog 2 monomer, 19 kDa Homo sapiens protein
Buffer: 20 mM Tris, 150 mM NaCl, pH: 7.2
Experiment: SAXS data collected at BM29, ESRF on 2015 Jul 2
Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling. Genes Dev 33(21-22):1506-1524 (2019)
Aragón E, Wang Q, Zou Y, Morgani SM, Ruiz L, Kaczmarska Z, Su J, Torner C, Tian L, Hu J, Shu W, Agrawal S, Gomes T, Márquez JA, Hadjantonakis AK, Macias MJ, Massagué J
RgGuinier 1.9 nm
Dmax 7.4 nm
VolumePorod 35 nm3

SASDG45 – Mothers against decapentaplegic homolog 2, S2MH1noE3

UniProt ID: Q15796-2 (10-143) Mothers against decapentaplegic homolog 2
Mothers against decapentaplegic homolog 2 experimental SAS data
Mothers against decapentaplegic homolog 2 Kratky plot
Sample: Mothers against decapentaplegic homolog 2 monomer, 16 kDa Homo sapiens protein
Buffer: 20 mM Tris, 150 mM NaCl, pH: 7.2
Experiment: SAXS data collected at BM29, ESRF on 2015 Jul 2
Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling. Genes Dev 33(21-22):1506-1524 (2019)
Aragón E, Wang Q, Zou Y, Morgani SM, Ruiz L, Kaczmarska Z, Su J, Torner C, Tian L, Hu J, Shu W, Agrawal S, Gomes T, Márquez JA, Hadjantonakis AK, Macias MJ, Massagué J
RgGuinier 1.7 nm
Dmax 6.6 nm
VolumePorod 31 nm3

SASDKZ8 – Mothers against decapentaplegic homolog 2, SMAD2, wild-type 0.74 mg/ml

UniProt ID: Q15796 (1-467) Mothers against decapentaplegic homolog 2
Mothers against decapentaplegic homolog 2 experimental SAS data
Mothers against decapentaplegic homolog 2 Kratky plot
Sample: Mothers against decapentaplegic homolog 2, 160 kDa Homo sapiens protein
Buffer: 20 mM Tris, 150 mM NaCl, pH: 7.2
Experiment: SAXS data collected at BM29, ESRF on 2016 Nov 11
Conformational landscape of multidomain SMAD proteins Computational and Structural Biotechnology Journal (2021)
Gomes T, Martin-Malpartida P, Ruiz L, Aragón E, Cordeiro T, Macias M
RgGuinier 3.4 nm
Dmax 15.0 nm

SASDK29 – Mothers against decapentaplegic homolog 2, SMAD2, wild-type 1.3 mg/ml

UniProt ID: Q15796 (1-467) Mothers against decapentaplegic homolog 2
Mothers against decapentaplegic homolog 2 experimental SAS data
Mothers against decapentaplegic homolog 2 Kratky plot
Sample: Mothers against decapentaplegic homolog 2, 160 kDa Homo sapiens protein
Buffer: 20 mM Tris, 150 mM NaCl, pH: 7.2
Experiment: SAXS data collected at BM29, ESRF on 2016 Nov 11
Conformational landscape of multidomain SMAD proteins Computational and Structural Biotechnology Journal (2021)
Gomes T, Martin-Malpartida P, Ruiz L, Aragón E, Cordeiro T, Macias M
RgGuinier 3.8 nm
Dmax 21.0 nm

SASDK39 – Mothers against decapentaplegic homolog 2, SMAD2, wild-type 2.5 mg/ml

UniProt ID: Q15796 (1-467) Mothers against decapentaplegic homolog 2
Mothers against decapentaplegic homolog 2 experimental SAS data
Mothers against decapentaplegic homolog 2 Kratky plot
Sample: Mothers against decapentaplegic homolog 2, 160 kDa Homo sapiens protein
Buffer: 20 mM Tris, 150 mM NaCl, pH: 7.2
Experiment: SAXS data collected at BM29, ESRF on 2016 Nov 11
Conformational landscape of multidomain SMAD proteins Computational and Structural Biotechnology Journal (2021)
Gomes T, Martin-Malpartida P, Ruiz L, Aragón E, Cordeiro T, Macias M
RgGuinier 3.8 nm
Dmax 20.0 nm

SASDK49 – Mothers against decapentaplegic homolog 2, SMAD2, wild-type 3mg/ml

UniProt ID: Q15796 (1-467) Mothers against decapentaplegic homolog 2
Mothers against decapentaplegic homolog 2 experimental SAS data
Mothers against decapentaplegic homolog 2 Kratky plot
Sample: Mothers against decapentaplegic homolog 2, 160 kDa Homo sapiens protein
Buffer: 20 mM Tris, 150 mM NaCl, pH: 7.2
Experiment: SAXS data collected at BM29, ESRF on 2016 Nov 11
Conformational landscape of multidomain SMAD proteins Computational and Structural Biotechnology Journal (2021)
Gomes T, Martin-Malpartida P, Ruiz L, Aragón E, Cordeiro T, Macias M
RgGuinier 4.3 nm
Dmax 23.0 nm

SASDK59 – Mothers against decapentaplegic homolog 2, SMAD2, linker fragment (amino acids 175-262)

UniProt ID: Q15796 (175-262) Mothers against decapentaplegic homolog 2 (linker)
Mothers against decapentaplegic homolog 2 (linker) experimental SAS data
Mothers against decapentaplegic homolog 2 (linker) Kratky plot
Sample: Mothers against decapentaplegic homolog 2 (linker) monomer, 10 kDa Homo sapiens protein
Buffer: 20 mM Tris, 150 mM NaCl, pH: 7.2
Experiment: SAXS data collected at BM29, ESRF on 2016 Nov 11
Conformational landscape of multidomain SMAD proteins Computational and Structural Biotechnology Journal (2021)
Gomes T, Martin-Malpartida P, Ruiz L, Aragón E, Cordeiro T, Macias M
RgGuinier 2.9 nm
Dmax 14.0 nm
VolumePorod 20 nm3

SASDK69 – Mothers against decapentaplegic homolog 2, SMAD2, linker-MH2 fragment (amino acids 186-467) 0.5 mg/ml

UniProt ID: Q15796 (186-467) Mothers against decapentaplegic homolog 2 (linker-MH2)
Mothers against decapentaplegic homolog 2 (linker-MH2) experimental SAS data
Mothers against decapentaplegic homolog 2 (linker-MH2) Kratky plot
Sample: Mothers against decapentaplegic homolog 2 (linker-MH2), 99 kDa Homo sapiens protein
Buffer: 20 mM Tris, 150 mM NaCl, pH: 7.2
Experiment: SAXS data collected at BM29, ESRF on 2016 Nov 11
Conformational landscape of multidomain SMAD proteins Computational and Structural Biotechnology Journal (2021)
Gomes T, Martin-Malpartida P, Ruiz L, Aragón E, Cordeiro T, Macias M
RgGuinier 3.6 nm
Dmax 15.0 nm

SASDK79 – Mothers against decapentaplegic homolog 2, SMAD2, linker-MH2 fragment (amino acids 186-467) 1.1 mg/ml

UniProt ID: Q15796 (186-467) Mothers against decapentaplegic homolog 2 (linker-MH2)
Mothers against decapentaplegic homolog 2 (linker-MH2) experimental SAS data
Mothers against decapentaplegic homolog 2 (linker-MH2) Kratky plot
Sample: Mothers against decapentaplegic homolog 2 (linker-MH2), 99 kDa Homo sapiens protein
Buffer: 20 mM Tris, 150 mM NaCl, pH: 7.2
Experiment: SAXS data collected at BM29, ESRF on 2016 Nov 11
Conformational landscape of multidomain SMAD proteins Computational and Structural Biotechnology Journal (2021)
Gomes T, Martin-Malpartida P, Ruiz L, Aragón E, Cordeiro T, Macias M
RgGuinier 3.7 nm
Dmax 17.0 nm

SASDK89 – Mothers against decapentaplegic homolog 2, SMAD2, linker-MH2 fragment (amino acids 186-467) 2.2 mg/ml

UniProt ID: Q15796 (186-467) Mothers against decapentaplegic homolog 2 (linker-MH2)
Mothers against decapentaplegic homolog 2 (linker-MH2) experimental SAS data
Mothers against decapentaplegic homolog 2 (linker-MH2) Kratky plot
Sample: Mothers against decapentaplegic homolog 2 (linker-MH2), 99 kDa Homo sapiens protein
Buffer: 20 mM Tris, 150 mM NaCl, pH: 7.2
Experiment: SAXS data collected at BM29, ESRF on 2016 Nov 11
Conformational landscape of multidomain SMAD proteins Computational and Structural Biotechnology Journal (2021)
Gomes T, Martin-Malpartida P, Ruiz L, Aragón E, Cordeiro T, Macias M
RgGuinier 4.2 nm
Dmax 19.0 nm