Small Angle Scattering Biological Data Bank SASBDB

Browse by DISSEMINATION: Published

SASDWE9 – Proliferating cell nuclear antigen:PCNA-associated factor (PCNA:P15) titration, 150 µM:300 µM

Proliferating cell nuclear antigenPCNA-associated factor experimental SAS data

Proliferating cell nuclear antigen PCNA-associated factor Kratky plot

Sample:	Proliferating cell nuclear antigen trimer, 87 kDa Homo sapiens protein PCNA-associated factor monomer, 12 kDa Homo sapiens protein
Buffer:	137 mM NaCl, 2.7 mM KCl, 10 mM sodium phosphate, 2 mM potassium phosphate (PBS), pH: 7
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2012 Apr 23

KDSAXS: A tool for Analyzing Binding Equilibria with SAXS Data using Explicit Models Journal of Molecular Biology :169103 (2025)
Gomes T, Ruiz L, Martin-Malpartida P, Bernadó P, Baptista A, Macias M, Cordeiro T

R_g^Guinier	3.9	nm
D_max	11.5	nm
Volume^Porod	194	nm³

SASDWF9 – Proliferating cell nuclear antigen:PCNA-associated factor (PCNA:P15) titration, 150 µM:370 µM

Sample:	Proliferating cell nuclear antigen trimer, 87 kDa Homo sapiens protein PCNA-associated factor monomer, 12 kDa Homo sapiens protein
Buffer:	137 mM NaCl, 2.7 mM KCl, 10 mM sodium phosphate, 2 mM potassium phosphate (PBS), pH: 7
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2012 Apr 23

R_g^Guinier	3.7	nm
D_max	11.0	nm
Volume^Porod	187	nm³

SASDSP8 – RNA Device 43 in ligand-free state (apo-D43)

RNA Device 43 in ligand-free state experimental SAS data

Sample:	RNA Device 43 in ligand-free state monomer, 40 kDa synthetic construct RNA
Buffer:	10 mM Bis-Tris, 100 mM KCl, and 1 mM MgCl2, pH: 6.8
Experiment:	SAXS data collected at 16-ID (LiX), National Synchrotron Light Source II (NSLS-II) on 2023 Jul 25

Structural investigation of an RNA device that regulates PD-1 expression in mammalian cells. Nucleic Acids Res 53(5) (2025)
Stagno JR, Deme JC, Dwivedi V, Lee YT, Lee HK, Yu P, Chen SY, Fan L, Degenhardt MFS, Chari R, Young HA, Lea SM, Wang YX

R_g^Guinier	3.4	nm
D_max	12.2	nm
Volume^Porod	58	nm³

SASDSQ8 – RNA Device 43 in ligand-bound state (holo-D43)

RNA Device 43 in ligand-bound state experimental SAS data

Sample:	RNA Device 43 in ligand-bound state monomer, 40 kDa synthetic construct RNA
Buffer:	10 mM Bis-Tris, 100 mM KCl, and 1 mM MgCl2, pH: 6.8
Experiment:	SAXS data collected at 16-ID (LiX), National Synchrotron Light Source II (NSLS-II) on 2023 Jul 25

R_g^Guinier	3.3	nm
D_max	12.1	nm
Volume^Porod	56	nm³

SASDWF4 – Outer membrane protein MIP from Legionella pneumophila (LpMIP) in complex with inhibitor NJS224

Outer membrane protein MIP(2S)‐2‐{[(2S)‐1‐[(4‐ fluorophenyl)methanesulfonyl]piperidin‐2‐ yl]formamido}‐4‐methyl‐N‐[(pyridin‐3‐ yl)methyl]pentanamide experimental SAS data

Sample:	Outer membrane protein MIP dimer, 46 kDa Legionella pneumophila subsp. … protein (2S)‐2‐{[(2S)‐1‐[(4‐ fluorophenyl)methanesulfonyl]piperidin‐2‐ yl]formamido}‐4‐methyl‐N‐[(pyridin‐3‐ yl)methyl]pentanamide monomer, 1 kDa
Buffer:	20 mM Tris, 150 mM NaCl, pH: 7.5
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2021 Nov 22

Structure and Dynamics of Macrophage Infectivity Potentiator Proteins from Pathogenic Bacteria and Protozoans Bound to Fluorinated Pipecolic Acid Inhibitors. J Med Chem (2025)
Pérez Carrillo VH, Whittaker JJ, Wiedemann C, Harder JM, Lohr T, Jamithireddy AK, Dajka M, Goretzki B, Joseph B, Guskov A, Harmer NJ, Holzgrabe U, Hellmich UA

R_g^Guinier	2.9	nm
D_max	9.7	nm
Volume^Porod	61	nm³

SASDWG4 – Outer membrane protein MIP from Legionella pneumophila (LpMIP) in complex with inhibitor NJS227

Outer membrane protein MIP(2S)‐3‐(4‐fluorophenyl)‐2‐{[(2S)‐1‐[(4‐ fluorophenyl)methanesulfonyl]piperidin‐2‐ yl]formamido}‐N‐[(pyridin‐3‐yl)methyl]propanamide experimental SAS data

Sample:	Outer membrane protein MIP dimer, 46 kDa Legionella pneumophila subsp. … protein (2S)‐3‐(4‐fluorophenyl)‐2‐{[(2S)‐1‐[(4‐ fluorophenyl)methanesulfonyl]piperidin‐2‐ yl]formamido}‐N‐[(pyridin‐3‐yl)methyl]propanamide monomer, 1 kDa
Buffer:	20 mM Tris, 150 mM NaCl, pH: 7.5
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2021 Nov 22

R_g^Guinier	3.0	nm
D_max	10.0	nm
Volume^Porod	65	nm³

SASDVK4 – Immunoglobulin light chain AL55

Immunoglobulin light chain AL55 experimental SAS data

Sample:	Immunoglobulin light chain AL55 dimer, 47 kDa Homo sapiens protein
Buffer:	20 mM TrisHCL, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at BM29, ESRF on 2022 Jan 15

A conformational fingerprint for amyloidogenic light chains eLife 13 (2025)
Paissoni C, Puri S, Broggini L, Sriramoju M, Maritan M, Russo R, Speranzini V, Ballabio F, Nuvolone M, Merlini G, Palladini G, Hsu S, Ricagno S, Camilloni C

R_g^Guinier	2.6	nm
D_max	8.5	nm
Volume^Porod	61	nm³

SASDVL4 – Immunoglobulin light chain H3

Immunoglobulin light chain H3 experimental SAS data

Sample:	Immunoglobulin light chain H3 dimer, 45 kDa Homo sapiens protein
Buffer:	20 mM TrisHCL, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2018 May 12

R_g^Guinier	2.6	nm
D_max	8.4	nm
Volume^Porod	56	nm³

SASDVM4 – Immunoglobulin light chain H7

Immunoglobulin light chain H7 experimental SAS data

Sample:	Immunoglobulin light chain H7 dimer, 45 kDa Homo sapiens protein
Buffer:	20 mM TrisHCL, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2018 May 12

R_g^Guinier	2.5	nm
D_max	8.4	nm
Volume^Porod	54	nm³

SASDVN4 – Immunoglobulin light chain H18

Immunoglobulin light chain H18 experimental SAS data

Sample:	Immunoglobulin light chain H18 dimer, 43 kDa Homo sapiens protein
Buffer:	20 mM TrisHCL, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at BM29, ESRF on 2021 Jul 2

R_g^Guinier	2.6	nm
D_max	8.2	nm
Volume^Porod	58	nm³

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