Small Angle Scattering Biological Data Bank SASBDB

Browse by MODEL: Hybrid

SASDMD4 – Plasmodium falciparum tyrosyl-tRNA synthetase, S234C mutant

Tyrosine--tRNA ligase (S234C) experimental SAS data

Sample:	Tyrosine--tRNA ligase (S234C) dimer, 87 kDa Plasmodium falciparum (isolate … protein
Buffer:	20 mM Tris-HCl, 150 mM NaCl, 0.5 mM TCEP, 0.1% sodium azide, pH: 7.4
Experiment:	SAXS data collected at SAXS/WAXS, Australian Synchrotron on 2021 Jun 4

Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy Science 376(6597):1074-1079 (2022)
Xie S, Metcalfe R, Dunn E, Morton C, Huang S, Puhalovich T, Du Y, Wittlin S, Nie S, Luth M, Ma L, Kim M, Pasaje C, Kumpornsin K, Giannangelo C, Houghton F, Churchyard A, Famodimu M, Barry D, Gillett D, Dey S, Kosasih C, Newman W, Niles J, Lee M, Baum J, Ottilie S, Winzeler E, Creek D, Williamson N, Parker M, Brand S, Langston S, Dick L, Griffin M, Gould A, Tilley L

R_g^Guinier	3.7	nm
D_max	12.0	nm
Volume^Porod	124	nm³

SASDME4 – Human tyrosyl tRNA synthetase

Tyrosine--tRNA ligase, cytoplasmic experimental SAS data

Sample:	Tyrosine--tRNA ligase, cytoplasmic dimer, 82 kDa Homo sapiens protein
Buffer:	20 mM Tris-HCl, 150 mM NaCl, 0.5 mM TCEP, 0.1% sodium azide, pH: 7.4
Experiment:	SAXS data collected at SAXS/WAXS, Australian Synchrotron on 2021 Jun 4

R_g^Guinier	3.6	nm
D_max	11.5	nm
Volume^Porod	118	nm³

SASDNB7 – C-terminal domain of pUL21 with N-terminal His-tag

Tegument protein UL21 (C-terminal domain) experimental SAS data

Sample:	Tegument protein UL21 (C-terminal domain) monomer, 29 kDa Human herpesvirus 1 … protein
Buffer:	20 mM Tris pH 8.5, 500 mM NaCl, 3% (v/v) glycerol, 1 mM DTT, pH: 8.5
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2020 Sep 25

Herpes simplex virus 1 protein pUL21 alters ceramide metabolism by activating the inter-organelle transport protein CERT Journal of Biological Chemistry :102589 (2022)
Benedyk T, Connor V, Caroe E, Shamin M, Svergun D, Deane J, Jeffries C, Crump C, Graham S

R_g^Guinier	2.2	nm
D_max	8.5	nm
Volume^Porod	49	nm³

SASDNC7 – miniCERTL with N-terminal His-tag

Ceramide transfer protein (recombinant CERTL: amino acids 20-130 and 351-624) experimental SAS data

Sample:	Ceramide transfer protein (recombinant CERTL: amino acids 20-130 and 351-624) monomer, 45 kDa Homo sapiens protein
Buffer:	20 mM Tris pH 8.5, 500 mM NaCl, 3% (v/v) glycerol, 1 mM DTT, pH: 8.5
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2020 Sep 25

R_g^Guinier	2.7	nm
D_max	9.1	nm
Volume^Porod	71	nm³

SASDND7 – Complex of H6-pUL21C and H6-miniCERTL

Tegument protein UL21 (C-terminal domain)Ceramide transfer protein (recombinant CERTL: amino acids 20-130 and 351-624) experimental SAS data

Sample:	Tegument protein UL21 (C-terminal domain) monomer, 29 kDa Human herpesvirus 1 … protein Ceramide transfer protein (recombinant CERTL: amino acids 20-130 and 351-624) monomer, 45 kDa Homo sapiens protein
Buffer:	20 mM Tris pH 8.5, 500 mM NaCl, 3% (v/v) glycerol, 1 mM DTT, pH: 8.5
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2020 Sep 25

R_g^Guinier	3.3	nm
D_max	13.6	nm
Volume^Porod	84	nm³

SASDNE7 – Complex of H6-miniCERTL and full-length pUL21-H6

Tegument protein UL21Ceramide transfer protein (recombinant CERTL: amino acids 20-130 and 351-624) experimental SAS data

Sample:	Tegument protein UL21 monomer, 59 kDa Human alphaherpesvirus 1 … protein Ceramide transfer protein (recombinant CERTL: amino acids 20-130 and 351-624) monomer, 45 kDa Homo sapiens protein
Buffer:	20 mM Tris pH 8.5, 500 mM NaCl, 3% (v/v) glycerol, 1 mM DTT, pH: 8.5
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2020 Sep 25

R_g^Guinier	4.1	nm
D_max	15.8	nm
Volume^Porod	158	nm³

SASDPF2 – Structure of an extracellular superoxide dismutase from Onchocerca volvulus

Extracellular superoxide dismutase [Cu-Zn] experimental SAS data

Sample:	Extracellular superoxide dismutase [Cu-Zn] dimer, 34 kDa Onchocerca volvulus protein
Buffer:	50 mM Tris-HCl, 200 mM NaCl, 2 mM DTT, pH: 8
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2013 Nov 13

Crystal structure of an extracellular superoxide dismutase from Onchocerca volvulus and implications for parasite-specific drug development Acta Crystallographica Section F Structural Biology Communications 78(6) (2022)
Moustafa A, Perbandt M, Liebau E, Betzel C, Falke S

R_g^Guinier	2.6	nm
D_max	9.0	nm
Volume^Porod	55	nm³

SASDPG2 – Spiegelmer NOX-E36, 1.15 mg/ml

Spiegelmer NOX-E36 experimental SAS data

Sample:	Spiegelmer NOX-E36 monomer, 13 kDa synthetic construct RNA
Buffer:	20 mM HEPES, pH: 7.5
Experiment:	SAXS data collected at EMBL X33, DORIS III, DESY on 2009 Feb 20

Spiegelmers® NOX-E36 and NOX-A12
Al Kikhney, Bara Schmidt

R_g^Guinier	2.1	nm
D_max	8.0	nm
Volume^Porod	18	nm³

SASDPH2 – Spiegelmer NOX-E36, 4.46 mg/ml

Sample:	Spiegelmer NOX-E36 monomer, 13 kDa synthetic construct RNA
Buffer:	20 mM HEPES, pH: 7.5
Experiment:	SAXS data collected at EMBL X33, DORIS III, DESY on 2009 Feb 20

Spiegelmers® NOX-E36 and NOX-A12
Al Kikhney, Bara Schmidt

R_g^Guinier

2.1

SASDPJ2 – Spiegelmer NOX-A12, 1.0 mg/ml

Spiegelmer NOX-A12 experimental SAS data

Sample:	Spiegelmer NOX-A12 monomer, 15 kDa synthetic construct RNA
Buffer:	20 mM HEPES, pH: 7.5
Experiment:	SAXS data collected at EMBL X33, DORIS III, DESY on 2009 Feb 20

Spiegelmers® NOX-E36 and NOX-A12
Al Kikhney, Bara Schmidt

R_g^Guinier	2.1	nm
D_max	7.8	nm
Volume^Porod	21	nm³

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