|
|
|
|
|
| Sample: |
Human immunoglobulin gamma 1 (IgG1) SAP1.3 - heavy chain dimer, 99 kDa Homo sapiens protein
Human immunoglobulin SAP1.3 - kappa chain dimer, 48 kDa Homo sapiens protein
|
| Buffer: |
50 mM HEPES, 150 mM KCl, pH: 7.5 |
| Experiment: |
SAXS
data collected at BM29, ESRF on 2024 Sep 28
|
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism.
Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
|
| RgGuinier |
5.2 |
nm |
| Dmax |
16.8 |
nm |
| VolumePorod |
229 |
nm3 |
|
|
|
|
|
|
|
| Sample: |
Human immunoglobulin SAP1.3 - kappa chain dimer, 48 kDa Homo sapiens protein
Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain dimer, 99 kDa Homo sapiens protein
|
| Buffer: |
50 mM HEPES, 150 mM KCl, pH: 7.5 |
| Experiment: |
SAXS
data collected at BM29, ESRF on 2024 Sep 28
|
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism.
Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
|
| RgGuinier |
4.9 |
nm |
| Dmax |
15.9 |
nm |
| VolumePorod |
214 |
nm3 |
|
|
|
|
|
|
|
| Sample: |
Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C226S dimer, 99 kDa Homo sapiens protein
Human immunoglobulin SAP1.3 - kappa chain C214S dimer, 48 kDa Homo sapiens protein
|
| Buffer: |
50 mM HEPES, 150 mM KCl, pH: 7.5 |
| Experiment: |
SAXS
data collected at BM29, ESRF on 2024 Sep 28
|
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism.
Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
|
| RgGuinier |
4.9 |
nm |
| Dmax |
15.8 |
nm |
| VolumePorod |
213 |
nm3 |
|
|
|
|
|
|
|
| Sample: |
Human immunoglobulin SAP1.3 - kappa chain C214S dimer, 48 kDa Homo sapiens protein
Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C227S dimer, 99 kDa Homo sapiens protein
|
| Buffer: |
50 mM HEPES, 150 mM KCl, pH: 7.5 |
| Experiment: |
SAXS
data collected at BM29, ESRF on 2024 Sep 28
|
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism.
Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
|
| RgGuinier |
4.9 |
nm |
| Dmax |
15.7 |
nm |
| VolumePorod |
222 |
nm3 |
|
|
|
|
|
|
|
| Sample: |
Human immunoglobulin SAP1.3 - kappa chain dimer, 48 kDa Homo sapiens protein
Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C226S/C227S dimer, 99 kDa Homo sapiens protein
|
| Buffer: |
50 mM HEPES, 150 mM KCl, pH: 7.5 |
| Experiment: |
SAXS
data collected at BM29, ESRF on 2024 Sep 28
|
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism.
Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
|
| RgGuinier |
5.0 |
nm |
| Dmax |
15.8 |
nm |
| VolumePorod |
222 |
nm3 |
|
|
|
|
|
|
|
| Sample: |
Heterochromatin protein HP1α, S97A mutant, full-length dimer, 41 kDa Homo sapiens protein
|
| Buffer: |
20 mM sodium phosphate, 50 mM NaCl, 1 mM DTT, pH: 7 |
| Experiment: |
SAXS
data collected at BL-10C, Photon Factory (PF), High Energy Accelerator Research Organization (KEK) on 2018 Jun 2
|
A dynamic structural unit of phase-separated heterochromatin protein 1α as revealed by integrative structural analyses
Nucleic Acids Research 53(6) (2025)
Furukawa A, Yonezawa K, Negami T, Yoshimura Y, Hayashi A, Nakayama J, Adachi N, Senda T, Shimizu K, Terada T, Shimizu N, Nishimura Y
|
| RgGuinier |
4.0 |
nm |
| Dmax |
14.4 |
nm |
| VolumePorod |
117 |
nm3 |
|
|
|
|
|
|
|
| Sample: |
Phosphorylated Heterochromatin protein HP1α, S97A mutant, full-length dimer, 41 kDa Homo sapiens protein
|
| Buffer: |
20 mM sodium phosphate, 50 mM NaCl, 1 mM DTT, pH: 7 |
| Experiment: |
SAXS
data collected at BL-10C, Photon Factory (PF), High Energy Accelerator Research Organization (KEK) on 2018 Jun 2
|
A dynamic structural unit of phase-separated heterochromatin protein 1α as revealed by integrative structural analyses
Nucleic Acids Research 53(6) (2025)
Furukawa A, Yonezawa K, Negami T, Yoshimura Y, Hayashi A, Nakayama J, Adachi N, Senda T, Shimizu K, Terada T, Shimizu N, Nishimura Y
|
| RgGuinier |
3.8 |
nm |
| Dmax |
19.5 |
nm |
| VolumePorod |
129 |
nm3 |
|
|
|
|
|
|
|
| Sample: |
Heterochromatin protein HP1α, S97A mutant, full-length dimer, 41 kDa Homo sapiens protein
|
| Buffer: |
20 mM sodium phosphate, 500 mM NaCl, 1mM DTT, pH: 7 |
| Experiment: |
SAXS
data collected at BL-10C, Photon Factory (PF), High Energy Accelerator Research Organization (KEK) on 2018 Nov 19
|
A dynamic structural unit of phase-separated heterochromatin protein 1α as revealed by integrative structural analyses
Nucleic Acids Research 53(6) (2025)
Furukawa A, Yonezawa K, Negami T, Yoshimura Y, Hayashi A, Nakayama J, Adachi N, Senda T, Shimizu K, Terada T, Shimizu N, Nishimura Y
|
| RgGuinier |
4.5 |
nm |
| Dmax |
17.1 |
nm |
| VolumePorod |
94 |
nm3 |
|
|
|
|
|
|
|
| Sample: |
Phosphorylated Heterochromatin protein HP1α, S97A mutant, full-length dimer, 41 kDa Homo sapiens protein
|
| Buffer: |
20 mM sodium phosphate, 500 mM NaCl, 1mM DTT, pH: 7 |
| Experiment: |
SAXS
data collected at BL-10C, Photon Factory (PF), High Energy Accelerator Research Organization (KEK) on 2018 Nov 19
|
A dynamic structural unit of phase-separated heterochromatin protein 1α as revealed by integrative structural analyses
Nucleic Acids Research 53(6) (2025)
Furukawa A, Yonezawa K, Negami T, Yoshimura Y, Hayashi A, Nakayama J, Adachi N, Senda T, Shimizu K, Terada T, Shimizu N, Nishimura Y
|
| RgGuinier |
4.6 |
nm |
| Dmax |
17.7 |
nm |
| VolumePorod |
104 |
nm3 |
|
|
|
|
|
|
|
| Sample: |
Heterochromatin protein HP1α, delta CSD mutant monomer, 13 kDa Homo sapiens protein
|
| Buffer: |
20 mM sodium phosphate, 50 mM NaCl, 1 mM DTT, pH: 7 |
| Experiment: |
SAXS
data collected at BL-15A2, Photon Factory (PF), High Energy Accelerator Research Organization (KEK) on 2020 Nov 27
|
A dynamic structural unit of phase-separated heterochromatin protein 1α as revealed by integrative structural analyses
Nucleic Acids Research 53(6) (2025)
Furukawa A, Yonezawa K, Negami T, Yoshimura Y, Hayashi A, Nakayama J, Adachi N, Senda T, Shimizu K, Terada T, Shimizu N, Nishimura Y
|
| RgGuinier |
2.8 |
nm |
| Dmax |
13.0 |
nm |
| VolumePorod |
23 |
nm3 |
|
|