Browse by MACROMOLECULE type: protein

SASDWW2 – Human immunoglobulin gamma 2 (IgG2) SAP1.3

Human immunoglobulin SAP1.3 - kappa chainHuman immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain experimental SAS data
Human immunoglobulin SAP1.3 - kappa chain Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain Kratky plot
Sample: Human immunoglobulin SAP1.3 - kappa chain dimer, 48 kDa Homo sapiens protein
Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain dimer, 99 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2024 Sep 28
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 4.9 nm
Dmax 15.9 nm
VolumePorod 214 nm3

SASDWX2 – Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C226S kappa chain C214S mutant

Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C226SHuman immunoglobulin SAP1.3 - kappa chain C214S experimental SAS data
Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C226S Human immunoglobulin SAP1.3 - kappa chain C214S Kratky plot
Sample: Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C226S dimer, 99 kDa Homo sapiens protein
Human immunoglobulin SAP1.3 - kappa chain C214S dimer, 48 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2024 Sep 28
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 4.9 nm
Dmax 15.8 nm
VolumePorod 213 nm3

SASDWY2 – Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C227S kappa chain C214S mutant

Human immunoglobulin SAP1.3 - kappa chain C214SHuman immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C227S experimental SAS data
Human immunoglobulin SAP1.3 - kappa chain C214S Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C227S Kratky plot
Sample: Human immunoglobulin SAP1.3 - kappa chain C214S dimer, 48 kDa Homo sapiens protein
Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C227S dimer, 99 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2024 Sep 28
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 4.9 nm
Dmax 15.7 nm
VolumePorod 222 nm3

SASDWZ2 – Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C226S/C227S mutant

Human immunoglobulin SAP1.3 - kappa chainHuman immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C226S/C227S experimental SAS data
Human immunoglobulin SAP1.3 - kappa chain Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C226S/C227S Kratky plot
Sample: Human immunoglobulin SAP1.3 - kappa chain dimer, 48 kDa Homo sapiens protein
Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C226S/C227S dimer, 99 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2024 Sep 28
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 5.0 nm
Dmax 15.8 nm
VolumePorod 222 nm3

SASDVV6 – Extended single alpha-helix (SAH) region of Drebrin

Drebrin experimental SAS data
OTHER [STATIC IMAGE] model
Sample: Drebrin monomer, 10 kDa Homo sapiens protein
Buffer: 17 mM NaH2PO4, 3 mM Na2HPO4, 50 mM NaCl, pH: 6
Experiment: SAXS data collected at EMBL P12, PETRA III on 2023 Jul 7
Dynamic Interchange of Local Residue-Residue Interactions in the Largely Extended Single Alpha-Helix in Drebrin Biochemical Journal (2025)
Varga S, Péterfia B, Dudola D, Farkas V, Jeffries C, Permi P, Gáspári Z
RgGuinier 3.0 nm
Dmax 12.0 nm
VolumePorod 18 nm3

SASDVZ8 – Pro-Trp-Trp-Pro (PWWP) domain from human DNA (cytosine-5)-methyltransferase 3B (DNMT3B)

DNA (cytosine-5)-methyltransferase 3B Pro-Trp-Trp-Pro (PWWP) domain experimental SAS data
GASBOR model
Sample: DNA (cytosine-5)-methyltransferase 3B Pro-Trp-Trp-Pro (PWWP) domain monomer, 17 kDa Homo sapiens protein
Buffer: 20 mM Tris, 300 mM NaCl, 1 mM TCEP, 5% glycerol, pH: 8
Experiment: SAXS data collected at 13A, Taiwan Photon Source, NSRRC on 2024 Apr 20
Histone modification-driven structural remodeling unleashes DNMT3B in DNA methylation. Sci Adv 11(13):eadu8116 (2025)
Cho CC, Huang HH, Jiang BC, Yang WZ, Chen YN, Yuan HS
RgGuinier 1.8 nm
Dmax 6.4 nm
VolumePorod 20464 nm3

SASDV29 – Complex of human DNA methyltransferase 3 beta DNMT3B (215-853) and DNA methyltransferase 3-like DNMT3L (178-379)

DNA methyltransferase 3 beta (215-853)DNA methyltransferase 3-like (178-379) experimental SAS data
GASBOR model
Sample: DNA methyltransferase 3 beta (215-853) dimer, 145 kDa Homo sapiens protein
DNA methyltransferase 3-like (178-379) dimer, 47 kDa Homo sapiens protein
Buffer: 20 mM Tris, 300 mM NaCl, 1 mM TCEP, 5% glycerol, pH: 8
Experiment: SAXS data collected at 13A, Taiwan Photon Source, NSRRC on 2021 Apr 16
Histone modification-driven structural remodeling unleashes DNMT3B in DNA methylation. Sci Adv 11(13):eadu8116 (2025)
Cho CC, Huang HH, Jiang BC, Yang WZ, Chen YN, Yuan HS
RgGuinier 5.2 nm
Dmax 21.2 nm
VolumePorod 271263 nm3

SASDVJ9 – Human DNA methyltransferase 3 beta DNMT3B (215-853) and DNA methyltransferase 3-like DNMT3L (178-379) in complex with histone H3

Histone H3.3DNA methyltransferase 3 beta (215-853) experimental SAS data
GASBOR model
Sample: Histone H3.3 dimer, 8 kDa Homo sapiens protein
DNA methyltransferase 3 beta (215-853) dimer, 145 kDa Homo sapiens protein
Buffer: 20 mM Tris, 300 mM NaCl, 1 mM TCEP, 5% glycerol, pH: 8
Experiment: SAXS data collected at 13A, Taiwan Photon Source, NSRRC on 2021 Apr 16
Histone modification-driven structural remodeling unleashes DNMT3B in DNA methylation. Sci Adv 11(13):eadu8116 (2025)
Cho CC, Huang HH, Jiang BC, Yang WZ, Chen YN, Yuan HS
RgGuinier 5.1 nm
Dmax 18.9 nm
VolumePorod 275 nm3

SASDVK9 – Pro-Trp-Trp-Pro (PWWP) domain from human DNA (cytosine-5)-methyltransferase 3B (DNMT3B) in complex with histone H3

Histone H3.3DNA (cytosine-5)-methyltransferase 3B Pro-Trp-Trp-Pro (PWWP) domain experimental SAS data
GASBOR model
Sample: Histone H3.3 monomer, 4 kDa Homo sa protein
DNA (cytosine-5)-methyltransferase 3B Pro-Trp-Trp-Pro (PWWP) domain monomer, 17 kDa Homo sapiens protein
Buffer: 20 mM Tris, 300 mM NaCl, 1 mM TCEP, 5% glycerol, pH: 8
Experiment: SAXS data collected at 13A, Taiwan Photon Source, NSRRC on 2024 Sep 17
Histone modification-driven structural remodeling unleashes DNMT3B in DNA methylation. Sci Adv 11(13):eadu8116 (2025)
Cho CC, Huang HH, Jiang BC, Yang WZ, Chen YN, Yuan HS
RgGuinier 1.8 nm
Dmax 7.4 nm
VolumePorod 19 nm3

SASDVL9 – Human DNA methyltransferase 3 beta DNMT3B (413-853) and DNA methyltransferase 3-like DNMT3L (178-379)

DNA methyltransferase 3-like (178-379)DNA methyltransferase 3 beta (413-853) experimental SAS data
GASBOR model
Sample: DNA methyltransferase 3-like (178-379) dimer, 47 kDa Homo sapiens protein
DNA methyltransferase 3 beta (413-853) dimer, 100 kDa Homo sapiens protein
Buffer: 20 mM Tris, 300 mM NaCl, 1 mM TCEP, 5% glycerol, pH: 8
Experiment: SAXS data collected at 13A, Taiwan Photon Source, NSRRC on 2022 Nov 2
Histone modification-driven structural remodeling unleashes DNMT3B in DNA methylation. Sci Adv 11(13):eadu8116 (2025)
Cho CC, Huang HH, Jiang BC, Yang WZ, Chen YN, Yuan HS
RgGuinier 4.5 nm
Dmax 15.9 nm
VolumePorod 191 nm3