Small Angle Scattering Biological Data Bank SASBDB

Browse by MACROMOLECULE type: protein

SASDX72 – Fatty acyl-CoA synthetase FadD5 with 2 mM coenzyme A (CoA)

Probable fatty-acid-CoA ligase FadD5 (Fatty-acid-CoA synthetase) (Fatty-acid-CoA synthase) experimental SAS data

Sample:	Probable fatty-acid-CoA ligase FadD5 (Fatty-acid-CoA synthetase) (Fatty-acid-CoA synthase) dimer, 123 kDa Mycobacterium tuberculosis (strain … protein
Buffer:	20 mM HEPES, 500 mM NaCl, 5 mM MgCl2, 1 mM β-mercaptoethanol, 2 mM coenzyme A (CoA), pH: 7.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2022 Oct 20

Structural enzymological studies of the long chain fatty acyl-CoA synthetase FadD5 from the mce1 operon of Mycobacterium tuberculosis. Biochem Biophys Res Commun 769:151960 (2025)
Rahman MA, Dalwani S, Venkatesan R

R_g^Guinier	3.7	nm
D_max	12.0	nm
Volume^Porod	210	nm³

SASDCN8 – SAXS data of Legionella pneumophila phosphocholine hydrolase Lem3(19-570)

Phosphocholine hydrolase Lem3 experimental SAS data

Phosphocholine hydrolase Lem3 Kratky plot

Sample:	Phosphocholine hydrolase Lem3 monomer, 63 kDa Legionella pneumophila subsp. … protein
Buffer:	300 mM NaCl, 2 mM 2-mercaptoethanol and 30 mM Tris-HCl, pH: 7.5
Experiment:	SAXS data collected at SWING, SOLEIL on 2015 Sep 20

The structural analysis of dephosphocholinase Legionella pneumophila Lem3
Wenhua Zhang

R_g^Guinier	3.5	nm
D_max	12.2	nm
Volume^Porod	95	nm³

SASDTW8 – Staphylococcus aureus Fatty Acid Kinase A

Uncharacterized protein SAUSA300_1119 experimental SAS data

Sample:	Uncharacterized protein SAUSA300_1119 dimer, 125 kDa Staphylococcus aureus (strain … protein
Buffer:	50 mM Tris, 150 mM KCl, 1 mM TCEP, 5% glycerol, pH: 7.4
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2022 Oct 5

Molecular insights into the structure and function of the Staphylococcus aureus fatty acid kinase. J Biol Chem 300(12):107920 (2024)
Myers MJ, Xu Z, Ryan BJ, DeMars ZR, Ridder MJ, Johnson DK, Krute CN, Flynn TS, Kashipathy MM, Battaile KP, Schnicker N, Lovell S, Freudenthal BD, Bose JL

R_g^Guinier	4.3	nm
D_max	16.0	nm
Volume^Porod	219	nm³

SASDV75 – S9 carboxypeptidase from Bacillus subtilis (4 mg/ml)

Putative acylaminoacyl-peptidase experimental SAS data

Sample:	Putative acylaminoacyl-peptidase tetramer, 293 kDa Bacillus spizizenii (strain … protein
Buffer:	10 mM Tris-HCl, 135 mM NaCl, pH: 8
Experiment:	SAXS data collected at BL-18, INDUS-2 on 2024 Mar 18

Structural adaptations for carboxypeptidase activity in putative S9 acylaminoacyl peptidase from Bacillus subtilis. Int J Biol Macromol :136734 (2024)
Chandravanshi K, Singh R, Kumar A, Bhange GN, Kumar A, Makde RD

R_g^Guinier	5.2	nm
D_max	15.9	nm
Volume^Porod	439	nm³

SASDV85 – S9 carboxypeptidase from Bacillus subtilis (6 mg/ml)

Sample:	Putative acylaminoacyl-peptidase tetramer, 293 kDa Bacillus spizizenii (strain … protein
Buffer:	10 mM Tris-HCl, 135 mM NaCl, pH: 8
Experiment:	SAXS data collected at BL-18, INDUS-2 on 2024 Mar 18

R_g^Guinier	5.2	nm
D_max	14.7	nm
Volume^Porod	435	nm³

SASDV95 – S9 carboxypeptidase from Bacillus subtilis (8 mg/ml)

Sample:	Putative acylaminoacyl-peptidase tetramer, 293 kDa Bacillus spizizenii (strain … protein
Buffer:	10 mM Tris-HCl, 135 mM NaCl, pH: 8
Experiment:	SAXS data collected at BL-18, INDUS-2 on 2024 Mar 18

R_g^Guinier	5.2	nm
D_max	15.3	nm
Volume^Porod	446	nm³

SASDU52 – Cereblon-midi (CRBNmidi), an engineered Cereblon construct for crystallographic and biophysical studies, apo form

Sample:	Cereblon-midi monomer, 37 kDa protein
Buffer:	20 mM Hepes, 500 mM NaCl, 0.5 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2023 Mar 1

Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders Nature Communications 15(1) (2024)
Kroupova A, Spiteri V, Rutter Z, Furihata H, Darren D, Ramachandran S, Chakraborti S, Haubrich K, Pethe J, Gonzales D, Wijaya A, Rodriguez-Rios M, Sturbaut M, Lynch D, Farnaby W, Nakasone M, Zollman D, Ciulli A

R_g^Guinier	2.7	nm
D_max	8.6	nm
Volume^Porod	61	nm³

SASDU62 – Cereblon-midi (CRBNmidi), an engineered Cereblon construct for crystallographic and biophysical studies, bound to Mezigdomide

Cereblon-midimezigdomide experimental SAS data

Sample:	Cereblon-midi monomer, 37 kDa protein Mezigdomide monomer, 1 kDa synthetic construct
Buffer:	20 mM Hepes, 500 mM NaCl, 0.5 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2023 Mar 1

R_g^Guinier	2.3	nm
D_max	7.3	nm
Volume^Porod	60	nm³

SASDU72 – Cereblon-midi (CRBNmidi), an engineered Cereblon construct for crystallographic and biophysical studies, bound to Pomalidomide

Cereblon-midipomalidomide experimental SAS data

Sample:	Cereblon-midi monomer, 37 kDa protein Pomalidomide monomer, 0 kDa synthetic construct
Buffer:	20 mM Hepes, 500 mM NaCl, 0.5 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2023 Mar 1

R_g^Guinier	2.3	nm
D_max	6.9	nm
Volume^Porod	63	nm³

SASDU82 – Cereblon-midi (CRBNmidi), an engineered Cereblon construct for crystallographic and biophysical studies, bound to Iberdomide

Cereblon-midiIberdomide experimental SAS data

Sample:	Cereblon-midi monomer, 37 kDa protein Iberdomide monomer, 0 kDa synthetic construct
Buffer:	20 mM Hepes, 500 mM NaCl, 0.5 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2023 Mar 1

R_g^Guinier	2.4	nm
D_max	7.7	nm
Volume^Porod	68	nm³

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