Small Angle Scattering Biological Data Bank SASBDB

Browse by ORGANISM: Homo sapiens (Human)

SASDUU7 – The tandem SH2 domains of Tyrosine-protein kinase SYK with a bound FCER1G diphospho-ITAM peptide

Tyrosine-protein kinase SYKHigh affinity immunoglobulin epsilon receptor subunit gamma experimental SAS data

Tyrosine-protein kinase SYK High affinity immunoglobulin epsilon receptor subunit gamma Kratky plot

Sample:	Tyrosine-protein kinase SYK monomer, 30 kDa Homo sapiens protein High affinity immunoglobulin epsilon receptor subunit gamma monomer, 2 kDa Homo sapiens protein
Buffer:	10 mM HEPES, 150 mM NaCl, 1 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2023 Nov 13

The mechanism of allosteric activation of SYK kinase derived from multiple phospho-ITAM-bound structures Structure (2024)
Bradshaw W, Harris G, Gileadi O, Katis V

R_g^Guinier	2.1	nm
D_max	7.0	nm
Volume^Porod	54	nm³

SASDUV7 – The tandem SH2 domains of Tyrosine-protein kinase SYK with a bound CD3G diphospho-ITAM peptide

Tyrosine-protein kinase SYKT-cell surface glycoprotein CD3 gamma chain experimental SAS data

Tyrosine-protein kinase SYK T-cell surface glycoprotein CD3 gamma chain Kratky plot

Sample:	Tyrosine-protein kinase SYK monomer, 30 kDa Homo sapiens protein T-cell surface glycoprotein CD3 gamma chain monomer, 3 kDa Homo sapiens protein
Buffer:	10 mM HEPES, 150 mM NaCl, 1 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2023 Nov 13

The mechanism of allosteric activation of SYK kinase derived from multiple phospho-ITAM-bound structures Structure (2024)
Bradshaw W, Harris G, Gileadi O, Katis V

R_g^Guinier	2.1	nm
D_max	7.1	nm
Volume^Porod	56	nm³

SASDUW7 – The tandem SH2 domains of Tyrosine-protein kinase SYK with a bound TYROBP diphospho-ITAM peptide

Tyrosine-protein kinase SYKTYRO protein tyrosine kinase-binding protein experimental SAS data

Tyrosine-protein kinase SYK TYRO protein tyrosine kinase-binding protein Kratky plot

Sample:	Tyrosine-protein kinase SYK monomer, 30 kDa Homo sapiens protein TYRO protein tyrosine kinase-binding protein monomer, 2 kDa Homo sapiens protein
Buffer:	10 mM HEPES, 150 mM NaCl, 1 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2023 Nov 13

The mechanism of allosteric activation of SYK kinase derived from multiple phospho-ITAM-bound structures Structure (2024)
Bradshaw W, Harris G, Gileadi O, Katis V

R_g^Guinier	2.1	nm
D_max	7.1	nm
Volume^Porod	53	nm³

SASDNW9 – Glucose-regulated protein 78, nucleotide-binding domain

Endoplasmic reticulum chaperone BiP experimental SAS data

Sample:	Endoplasmic reticulum chaperone BiP monomer, 42 kDa Homo sapiens protein
Buffer:	phosphate buffered saline, pH: 7.2
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2021 Mar 21

Structural basis of CDNF interaction with the UPR regulator GRP78. Nat Commun 15(1):8175 (2024)
Graewert MA, Volkova M, Jonasson K, Määttä JAE, Gräwert T, Mamidi S, Kulesskaya N, Evenäs J, Johnsson RE, Svergun D, Bhattacharjee A, Huttunen HJ

R_g^Guinier	2.2	nm
D_max	6.5	nm
Volume^Porod	70	nm³

SASDNX9 – Glucose-regulated protein 78 nucleotide-binding domain (GRP78-NBD) in complex with Cerebral dopamine neurotrophic factor (CDNF)

Endoplasmic reticulum chaperone BiPCerebral dopamine neurotrophic factor experimental SAS data

Sample:	Endoplasmic reticulum chaperone BiP monomer, 42 kDa Homo sapiens protein Cerebral dopamine neurotrophic factor monomer, 21 kDa Homo sapiens protein
Buffer:	phosphate buffered saline, pH: 7.2
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2021 Mar 21

R_g^Guinier	2.8	nm
D_max	10.0	nm
Volume^Porod	75	nm³

SASDQS6 – Glucose-regulated protein 78 nucleotide-binding domain (GRP78-NBD) in complex with the C-terminal of Cerebral dopamine neurotrophic factor (C-CDNF)

Endoplasmic reticulum chaperone BiPC-terminal of the Cerebral dopamine neurotrophic factor experimental SAS data

Sample:	Endoplasmic reticulum chaperone BiP monomer, 42 kDa Homo sapiens protein C-terminal of the Cerebral dopamine neurotrophic factor monomer, 7 kDa Homo sapiens protein
Buffer:	phosphate buffered saline, pH: 7.2
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2021 Mar 23

R_g^Guinier	2.4	nm
D_max	6.9	nm
Volume^Porod	66	nm³

SASDUQ4 – Calcium/calmodulin-dependent protein kinase type II alpha (CaMKIIα) WT hub domain

Calcium/calmodulin-dependent protein kinase type II subunit alpha experimental SAS data

Sample:	Calcium/calmodulin-dependent protein kinase type II subunit alpha dodecamer, 186 kDa Homo sapiens protein
Buffer:	20 mM MES, 150 mM NaCl, 1 mM DTT, pH: 6
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2022 Oct 3

Ligand‐induced CaMKIIα hub Trp403 flip, hub domain stacking, and modulation of kinase activity Protein Science 33(10) (2024)
Narayanan D, Larsen A, Gauger S, Adafia R, Hammershøi R, Hamborg L, Bruus‐Jensen J, Griem‐Krey N, Gee C, Frølund B, Stratton M, Kuriyan J, Kastrup J, Langkilde A, Wellendorph P, Solbak S

R_g^Guinier	4.5	nm
D_max	15.2	nm
Volume^Porod	367	nm³

SASDUR4 – Calcium/calmodulin-dependent protein kinase type II alpha (CaMKIIα) WT hub domain

Sample:	Calcium/calmodulin-dependent protein kinase type II subunit alpha dodecamer, 186 kDa Homo sapiens protein
Buffer:	20 mM MES, 150 mM NaCl, 1 mM DTT, pH: 6
Experiment:	SAXS data collected at Xenocs BioXolver L with MetalJet, University of Copenhagen, Department of Drug Design and Pharmacology on 2020 Nov 19

R_g^Guinier	4.4	nm
D_max	14.9	nm
Volume^Porod	351	nm³

SASDUS4 – Calcium/calmodulin-dependent protein kinase type II alpha (CaMKIIα) WT hub domain with PIPA (i)

Calcium/calmodulin-dependent protein kinase type II subunit alpha2-(6-(4-chlorophenyl)imidazo[1,2-b]pyridazine-2-yl)acetic acid experimental SAS data

Sample:	Calcium/calmodulin-dependent protein kinase type II subunit alpha dodecamer, 186 kDa Homo sapiens protein 2-(6-(4-chlorophenyl)imidazo[1,2-b]pyridazine-2-yl)acetic acid monomer, 0 kDa
Buffer:	20 mM MES, 150 mM NaCl, 1 mM DTT, 200 µM PIPA, pH: 6
Experiment:	SAXS data collected at Xenocs BioXolver L with MetalJet, University of Copenhagen, Department of Drug Design and Pharmacology on 2022 Nov 30

R_g^Guinier	4.8	nm
D_max	16.0	nm
Volume^Porod	396	nm³

SASDUT4 – Calcium/calmodulin-dependent protein kinase type II alpha (CaMKIIα) WT hub domain with PIPA (ii)

Sample:	Calcium/calmodulin-dependent protein kinase type II subunit alpha dodecamer, 186 kDa Homo sapiens protein 2-(6-(4-chlorophenyl)imidazo[1,2-b]pyridazine-2-yl)acetic acid monomer, 0 kDa
Buffer:	20 mM MES, 150 mM NaCl, 1 mM DTT, 200 µM PIPA, pH: 6
Experiment:	SAXS data collected at Xenocs BioXolver L with MetalJet, University of Copenhagen, Department of Drug Design and Pharmacology on 2023 May 30

R_g^Guinier	5.5	nm
D_max	27.0	nm

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