Browse by ORGANISM: Homo sapiens (Human)

SASDT72 – GAGE6 60bp dsDNA oligonucleotide

GAGE6 60bp dsDNA oligo experimental SAS data
DAMMIN model
Sample: GAGE6 60bp dsDNA oligo monomer, 37 kDa Homo sapiens DNA
Buffer: 150 mM KCl, 20 mM HEPES, 5% glycerol, 5 mM MgCl2, 1 mM DTT, pH: 7.5
Experiment: SAXS data collected at SAXS/WAXS, Australian Synchrotron on 2023 Mar 14
Probing the statistics of sequence-dependent DNA conformations in solution using SAXS
Heidar Koning
RgGuinier 4.7 nm
Dmax 20.7 nm
VolumePorod 101 nm3

SASDV87 – The 60bp dsDNA oligo GAGE6_1

GAGE6_1 experimental SAS data
GAGE6_1 Kratky plot
Sample: GAGE6_1 dimer, 37 kDa Homo sapiens DNA
Buffer: 150 mM KCl, 20 mM HEPES, 5% glycerol, 5 mM MgCl2, 1 mM DTT, pH: 7.5
Experiment: SAXS data collected at SAXS/WAXS, Australian Synchrotron on 2023 Nov 28
Probing the statistics of sequence-dependent DNA conformations in solution using SAXS
Heidar Koning
RgGuinier 5.1 nm
Dmax 19.2 nm
VolumePorod 67 nm3

SASDV97 – The 60bp dsDNA oligo GAGE6_2

GAGE6_2 experimental SAS data
GAGE6_2 Kratky plot
Sample: GAGE6_2 dimer, 37 kDa Homo sapiens DNA
Buffer: 150 mM KCl, 20 mM HEPES, 5% glycerol, 5 mM MgCl2, 1 mM DTT, pH: 7.5
Experiment: SAXS data collected at SAXS/WAXS, Australian Synchrotron on 2023 Nov 28
Probing the statistics of sequence-dependent DNA conformations in solution using SAXS
Heidar Koning
RgGuinier 5.2 nm
Dmax 18.4 nm
VolumePorod 72 nm3

SASDVA7 – The 60bp dsDNA oligo GAGE6_3

GAGE6_3 experimental SAS data
GAGE6_3 Kratky plot
Sample: GAGE6_3 dimer, 37 kDa Homo sapiens DNA
Buffer: 150 mM KCl, 20 mM HEPES, 5% glycerol, 5 mM MgCl2, 1 mM DTT, pH: 7.5
Experiment: SAXS data collected at SAXS/WAXS, Australian Synchrotron on 2023 Nov 28
Probing the statistics of sequence-dependent DNA conformations in solution using SAXS
Heidar Koning
RgGuinier 5.0 nm
Dmax 21.4 nm
VolumePorod 80 nm3

SASDVC4 – Shwachman-Bodian-Diamond syndrome protein (SBDS) - wild type

Ribosome maturation protein SBDS experimental SAS data
MULTIFOXS model
Sample: Ribosome maturation protein SBDS monomer, 29 kDa Homo sapiens protein
Buffer: 50 mM Tris pH 8.0, 10% glycerol, 300 mM NaCl, 5 mM MgCl2., pH:
Experiment: SAXS data collected at EMBL P12, PETRA III on 2022 Apr 6
Structural Implications of Missense Point Mutations in Shwachman–Bodian–Diamond Syndrome Protein (SBDS): A Combined SAXS/MD Investigation ACS Omega (2025)
Mattiotti G, Nanna V, Giulini M, Alberga D, Mangiatordi G, Sánchez-Puig N, Saviano M, Tubiana L, Potestio R, Lattanzi G, Siliqi D
RgGuinier 3.0 nm
Dmax 11.4 nm
VolumePorod 50 nm3

SASDVD4 – Shwachman-Bodian-Diamond syndrome protein (SBDS) - R19Q mutant

Ribosome maturation protein SBDS (R19Q) experimental SAS data
MULTIFOXS model
Sample: Ribosome maturation protein SBDS (R19Q) monomer, 29 kDa Homo sapiens protein
Buffer: 50 mM Tris pH 8.0, 10% glycerol, 300 mM NaCl, 5 mM MgCl2., pH:
Experiment: SAXS data collected at EMBL P12, PETRA III on 2022 Apr 6
Structural Implications of Missense Point Mutations in Shwachman–Bodian–Diamond Syndrome Protein (SBDS): A Combined SAXS/MD Investigation ACS Omega (2025)
Mattiotti G, Nanna V, Giulini M, Alberga D, Mangiatordi G, Sánchez-Puig N, Saviano M, Tubiana L, Potestio R, Lattanzi G, Siliqi D
RgGuinier 2.9 nm
Dmax 12.2 nm
VolumePorod 46 nm3

SASDVE4 – Shwachman-Bodian-Diamond syndrome protein (SBDS) - I167T mutant

Ribosome maturation protein SBDS (I167T) experimental SAS data
MULTIFOXS model
Sample: Ribosome maturation protein SBDS (I167T) monomer, 29 kDa Homo sapiens protein
Buffer: 50 mM Tris pH 8.0, 10% glycerol, 300 mM NaCl, 5 mM MgCl2., pH:
Experiment: SAXS data collected at EMBL P12, PETRA III on 2022 Apr 6
Structural Implications of Missense Point Mutations in Shwachman–Bodian–Diamond Syndrome Protein (SBDS): A Combined SAXS/MD Investigation ACS Omega (2025)
Mattiotti G, Nanna V, Giulini M, Alberga D, Mangiatordi G, Sánchez-Puig N, Saviano M, Tubiana L, Potestio R, Lattanzi G, Siliqi D
RgGuinier 2.9 nm
Dmax 10.5 nm
VolumePorod 44 nm3

SASDVF4 – Shwachman-Bodian-Diamond syndrome protein (SBDS) - R175W mutant

Ribosome maturation protein SBDS (R175W) experimental SAS data
MULTIFOXS model
Sample: Ribosome maturation protein SBDS (R175W) monomer, 29 kDa Homo sapiens protein
Buffer: 50 mM Tris pH 8.0, 10% glycerol, 300 mM NaCl, 5 mM MgCl2., pH:
Experiment: SAXS data collected at EMBL P12, PETRA III on 2022 Apr 6
Structural Implications of Missense Point Mutations in Shwachman–Bodian–Diamond Syndrome Protein (SBDS): A Combined SAXS/MD Investigation ACS Omega (2025)
Mattiotti G, Nanna V, Giulini M, Alberga D, Mangiatordi G, Sánchez-Puig N, Saviano M, Tubiana L, Potestio R, Lattanzi G, Siliqi D
RgGuinier 3.1 nm
Dmax 11.6 nm
VolumePorod 48 nm3

SASDVC9 – 7SK small nuclear RNA State A Low Magnesium Concentration Ensemble

RNA component of 7SK nuclear ribonucleoprotein experimental SAS data
DAMMIN model
Sample: RNA component of 7SK nuclear ribonucleoprotein monomer, 107 kDa Homo sapiens RNA
Buffer: 10 mM Bis-Tris, 100 mM NaCl, 15 mM KCl, 5% Glycerol, 3 mM MgCl2, pH: 5.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Jun 21
Solution Structure Determination and Biophysical Studies of 7SK RNP and 7SL SRP RNAs. RNA (2025)
D'Souza MH, Pereira HS, Tersteeg S, Vasudeva G, Siddiqui MQ, Agunlejika T, Kerr L, Girodat D, Patel T
RgGuinier 8.0 nm
Dmax 23.2 nm
VolumePorod 600 nm3

SASDVD9 – 7SK small nuclear RNA State B Low Magnesium Concentration Ensemble

RNA component of 7SK nuclear ribonucleoprotein experimental SAS data
DAMMIN model
Sample: RNA component of 7SK nuclear ribonucleoprotein monomer, 107 kDa Homo sapiens RNA
Buffer: 10 mM Bis-Tris, 100 mM NaCl, 15 mM KCl, 5% Glycerol, 3 mM MgCl2, pH: 5.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Jun 21
Solution Structure Determination and Biophysical Studies of 7SK RNP and 7SL SRP RNAs. RNA (2025)
D'Souza MH, Pereira HS, Tersteeg S, Vasudeva G, Siddiqui MQ, Agunlejika T, Kerr L, Girodat D, Patel T
RgGuinier 7.9 nm
Dmax 24.1 nm
VolumePorod 290 nm3