Crystal Structure of an Engineered LRRTM2 Synaptic Adhesion Molecule and a Model for Neurexin Binding.

Paatero A, Rosti K, Shkumatov AV, Sele C, Brunello C, Kysenius K, Singha P, Jokinen V, Huttunen H, Kajander T
Biochemistry 55(6):914-26 (2016 Feb 16)

PMID: 26785044 doi: 10.1021/acs.biochem.5b00971

Submitted to SASBDB: 2016 Jan 25 Published in SASBDB: 2016 Jan 26

SASDBG3 – Leucine-rich repeat transmembrane neuronal protein 2, cLRRTM2 (stability engineered construct) Sample: Mouse Leucine-rich repeat transmembrane neuronal protein 2, cLRRTM2 (stability engineered construct) monomer, 40 kDa Mus musculus protein Buffer: 20 mM Tris 150 mM NaCl 3% glycerol, pH: 7.4 Experiment: SAXS data collected at ID14-3, ESRF on 2015 Sep 27 RgGuinier 3.3 nm Dmax 13.1 nm

SASDBH3 – Leucine-rich repeat transmembrane neuronal protein 2, LRRTM2 (fragment 30-380) Sample: Mouse Leucine-rich repeat transmembrane neuronal protein 2, LRRTM2 dimer, 80 kDa Mus musculus protein Buffer: 20 mM Tris 150 mM NaCl 3% glycerol, pH: 7.4 Experiment: SAXS data collected at ID14-3, ESRF on 2015 Jun 28 RgGuinier 4.2 nm Dmax 21.6 nm