Bacterial targeting of the neutrophil inhibitory receptor LILRB3 to evade antibody immunity.

Rumpret M, Lewis Marffy AL, Zhang Y, van Woudenbergh E, van der Lans SPA, Xu X, Fu Z, Zhao Y, Catton EA, Paré G, McGregor F, Spiller OB, Fernandes MJ, de Haas CJC, van Strijp JAG, van Sorge NM, Geisbrecht BV, McCarthy AJ
Nat Commun (2026 Jun 11)

PMID: 42277001 doi: 10.1038/s41467-026-74098-6

Submitted to SASBDB: 2024 Jul 11 Published in SASBDB: 2026 Jun 16

SASDXH8 – Leukocyte Immunoglobulin-Like Receptor LILR-B3 Sample: Leukocyte immunoglobulin-like receptor subfamily B member 3 (P288R) monomer, 47 kDa Homo sapiens protein Buffer: 20mM HEPES, 140mM NaCl, pH: 7.4 Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2023 Oct 5 RgGuinier 3.6 nm Dmax 13.5 nm VolumePorod 137 nm3

SASDVA4 – β-Antigen C Protein B6C domain bound to Leukocyte Immunoglobulin-Like Receptor LILR-B3 Sample: IgA FC receptor monomer, 20 kDa Streptococcus agalactiae protein Leukocyte immunoglobulin-like receptor subfamily B member 3 (P288R) monomer, 47 kDa Homo sapiens protein Buffer: 20 mM HEPES, 300 mM NaCl, pH: 7.4 Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2023 Nov 17 RgGuinier 3.9 nm Dmax 13.5 nm VolumePorod 202 nm3

SASDVB4 – β-Antigen C Protein B75KN-CTD domain bound to Leukocyte Immunoglobulin-Like Receptor LILR-B3 Sample: Leukocyte immunoglobulin-like receptor subfamily B member 3 (P288R) monomer, 47 kDa Homo sapiens protein IgA FC receptor (N770H) monomer, 12 kDa Streptococcus agalactiae protein Buffer: 20 mM HEPES, 300 mM NaCl, pH: 7.4 Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2023 Nov 17 RgGuinier 3.9 nm Dmax 14.1 nm VolumePorod 175 nm3

SASDXG8 – Streptococcus agalactiae IgA FC receptor Sample: IgA FC receptor β-Antigen C Protein monomer, 71 kDa Streptococcus agalactiae protein Buffer: 20mM HEPES, 140mM NaCl, pH: 7.4 Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2023 Oct 5 RgGuinier 5.9 nm Dmax 20.2 nm VolumePorod 140 nm3

SASDXF8 – β-Antigen C Protein bound to Leukocyte Immunoglobulin-Like Receptor LILR-B3 Sample: IgA FC receptor β-Antigen C Protein monomer, 71 kDa Streptococcus agalactiae protein Leukocyte immunoglobulin-like receptor subfamily B3 monomer, 94 kDa Homo sapiens protein Buffer: 20mM HEPES, 140mM NaCl, pH: 7.4 Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2023 Oct 5 RgGuinier 7.0 nm Dmax 26.5 nm VolumePorod 447 nm3