A class III ligand oscillates between internal and terminal binding modes as it engages with the Dishevelled PDZ domain.
Kumar J,
Micka M,
Komárek J,
Klumpler T,
Bystrý V,
Sprangers R,
Bařinka C,
Bryja V,
Tripsianes K
Structure
(2025 Jun 5)
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Sample: |
Segment polarity protein dishevelled homolog DVL-3 monomer, 12 kDa Homo sapiens protein
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Buffer: |
50 mM sodium phosphate, 50 mM NaCl, 0.5 mM EDTA, pH: 6.5 |
Experiment: |
SAXS
data collected at Rigaku BioSAXS-2000, CEITEC on 2021 Jan 27
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RgGuinier |
1.6 |
nm |
Dmax |
4.3 |
nm |
VolumePorod |
20 |
nm3 |
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