A class III ligand oscillates between internal and terminal binding modes as it engages with the Dishevelled PDZ domain.

Kumar J, Micka M, Komárek J, Klumpler T, Bystrý V, Sprangers R, Bařinka C, Bryja V, Tripsianes K
Structure (2025 Jun 5)
PMID: 40516532
doi: 10.1016/j.str.2025.05.012
Submitted to SASBDB: 2025 Feb 25
Published in SASBDB:

SASDWG9 – PDZ domain of the segment polarity protein dishevelled homolog DVL-3

Segment polarity protein dishevelled homolog DVL-3 experimental SAS data
REFMAC model
Sample: Segment polarity protein dishevelled homolog DVL-3 monomer, 12 kDa Homo sapiens protein
Buffer: 50 mM sodium phosphate, 50 mM NaCl, 0.5 mM EDTA, pH: 6.5
Experiment: SAXS data collected at Rigaku BioSAXS-2000, CEITEC on 2021 Jan 27
RgGuinier 1.6 nm
Dmax 4.3 nm
VolumePorod 20 nm3