The herpes viral transcription factor ICP4 forms a novel DNA recognition complex.

Tunnicliffe RB, Lockhart-Cairns MP, Levy C, Mould AP, Jowitt TA, Sito H, Baldock C, Sandri-Goldin RM, Golovanov AP
Nucleic Acids Res 45(13):8064-8078 (2017 Jul 27)

PMID: 28505309 doi: 10.1093/nar/gkx419

Submitted to SASBDB: 2016 Nov 28 Published in SASBDB: 2017 May 30

SASDB68 – Immediate Early 3 DNA (ICP4N IE3_19mer) Sample: Immediate Early 3 dimer, 12 kDa DNA Buffer: 20 mM HEPES, 150 mM NaCl, pH: 7.4 Experiment: SAXS data collected at BM29, ESRF on 2015 Nov 12 RgGuinier 1.9 nm Dmax 6.9 nm

SASDB58 – Major viral transcription factor ICP4 (ICP4N dimer) Sample: Major viral transcription factor ICP4 dimer, 49 kDa Human alphaherpesvirus 1 protein Buffer: 20 mM HEPES, 150 mM NaCl, pH: 7.4 Experiment: SAXS data collected at B21, Diamond Light Source on 2015 Jul 27 RgGuinier 2.9 nm Dmax 12.7 nm

SASDB48 – Major viral transcription factor ICP4/Immediate Early 3 DNA (ICP4N IE3_19mer) complex Sample: Major viral transcription factor ICP4 dimer, 49 kDa Human alphaherpesvirus 1 protein Immediate Early 3 dimer, 12 kDa DNA Buffer: 20 mM HEPES, 150 mM NaCl, pH: 7.4 Experiment: SAXS data collected at B21, Diamond Light Source on 2015 Jul 27 RgGuinier 2.5 nm Dmax 8.3 nm VolumePorod 90 nm3