Targeting the phosphoprotein enriched in diabetes/astrocytes 15 death effector domain via fragment-based and integrative structural biology approaches.

Mercurio I, Carucci F, Nanna V, Di Marino S, Papadopoulos MGE, Bischetti M, Fata F, Malgieri G, Siliqi D, Piai A, Fattorusso R, Mangiatordi GF, Toniatti C, Saviano M, Alberga D
Int J Biol Macromol :154849 (2026 Oct 16)
PMID: 42887742
doi: 10.1016/j.ijbiomac.2026.154849 		Submitted to SASBDB: 2025 May 26
Published in SASBDB:

SASDX25 – Wild type astrocytic phosphoprotein PEA-15

Astrocytic phosphoprotein PEA-15 experimental SAS data
GASBOR model
Sample: Astrocytic phosphoprotein PEA-15 monomer, 15 kDa Cricetulus griseus protein
Buffer: 20 mM Na2PO4, 2 mM DTT, pH: 7
Experiment: SAXS data collected at EMBL P12, PETRA III on 2024 Nov 22
RgGuinier 2.2 nm
Dmax 11.0 nm
VolumePorod 27 nm3

SASDX35 – DD mutant astrocytic phosphoprotein PEA-15

Astrocytic phosphoprotein PEA-15 (S104D, S116D) experimental SAS data
GASBOR model
Sample: Astrocytic phosphoprotein PEA-15 (S104D, S116D) monomer, 15 kDa Cricetulus griseus protein
Buffer: 20 mM Na2PO4, 2 mM DTT, pH: 7
Experiment: SAXS data collected at EMBL P12, PETRA III on 2024 Nov 22
RgGuinier 2.4 nm
Dmax 12.7 nm
VolumePorod 27 nm3