Modulation of Homer1 EVH1 domain internal dynamics by putative autism-associated mutations.

Farkas F, Maruzs B, Kálmán ZE, Klumpler T, Batta G, Péterfia B, Gáspári Z
FEBS Lett (2026 May 28)
PMID: 42206738
doi: 10.1002/1873-3468.70369 		Submitted to SASBDB: 2025 Dec 10
Published in SASBDB:

SASDYW3 – Point mutant M65I of EVH1 domain of Homer protein homolog 1 from mouse monomer

Point mutant M65I of EVH1 domain of Homer protein homolog 1 from mouse monomer experimental SAS data
GROMACS model
Sample: Point mutant M65I of EVH1 domain of Homer protein homolog 1 from mouse monomer monomer, 14 kDa Mus musculus protein
Buffer: 20mM NaCl, 50 mM NaPi, 0.02% of sodium-azide, pH: 7.4
Experiment: SAXS data collected at Rigaku BioSAXS-2000, CEITEC on 2023 Nov 8
RgGuinier 1.7 nm
Dmax 5.3 nm
VolumePorod 24 nm3

SASDYX3 – Point mutant S97L of EVH1 domain of Homer protein homolog 1 from mouse monomer

Point mutant S97L of EVH1 domain of Homer protein homolog 1 from mouse monomer experimental SAS data
GROMACS model
Sample: Point mutant S97L of EVH1 domain of Homer protein homolog 1 from mouse monomer monomer, 14 kDa Mus musculus protein
Buffer: 20mM NaCl, 50 mM NaPi, 0.02% of sodium-azide, pH: 7.4
Experiment: SAXS data collected at Rigaku BioSAXS-2000, CEITEC on 2023 Nov 8
RgGuinier 1.7 nm
Dmax 4.3 nm
VolumePorod 23 nm3