An intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6.

Capraro F, Abis G, Incocciati A, Simpson PJ, Karimzadeh M, Masino L, Barley A, Bui TTT, Kelly G, Goodarzi H, Conte MR, Mardakheh FK
Nat Commun (2026 Feb 19)

PMID: 41714637 doi: 10.1038/s41467-026-69789-z

Submitted to SASBDB: 2026 Jan 20 Published in SASBDB: 2026 Feb 21

SASDYW5 – La-related protein 6 (LARP6) La-module apo Sample: La-related protein 6 monomer, 27 kDa Homo sapiens protein Buffer: 25 mM Tris-HCl, 100 mM KCl, 5 mM MgCl2, 1 mM DTT, pH: 7.5 Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Oct 1 RgGuinier 2.9 nm Dmax 8.3 nm VolumePorod 59 nm3

SASDYX5 – La-related protein 6 (LARP6) N-terminal domain (NTD) apo Sample: La-related protein 6 monomer, 34 kDa Homo sapiens protein Buffer: 25 mM Tris-HCl, 100 mM KCl, 5 mM MgCl2, 1 mM DTT, pH: 7.5 Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Oct 1 RgGuinier 3.6 nm Dmax 15.0 nm VolumePorod 138 nm3

SASDYY5 – La-related protein 6 (LARP6) N-terminal region (NTR) apo Sample: La-related protein 6 monomer, 9 kDa Homo sapiens protein Buffer: 25 mM Tris-HCl, 100 mM KCl, 5 mM MgCl2, 1 mM DTT, pH: 7.5 Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Oct 1 RgGuinier 2.7 nm Dmax 9.4 nm VolumePorod 21 nm3

SASDYZ5 – La-related protein 6 (LARP6) La-module bound to CTNNA1 P1 RNA, a fragment of the 3'-untranslated region of catenin alpha 1 mRNA Sample: La-related protein 6 monomer, 35 kDa Homo sapiens protein 3'-untranslated region of catenin alpha 1 mRNA, 8 kDa RNA Buffer: 25 mM Tris-HCl, 100 mM KCl, 5 mM MgCl2, 1 mM DTT, pH: 7.5 Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Oct 1 RgGuinier 3.0 nm Dmax 12.0 nm VolumePorod 100 nm3

SASDY26 – La-related protein 6 (LARP6) N-terminal domain (NTD) bound to CTNNA1 P1 RNA, a fragment of the 3'-untranslated region of catenin alpha 1 Sample: La-related protein 6 monomer, 42 kDa Homo sapiens protein 3'-untranslated region of catenin alpha 1 mRNA, 8 kDa RNA Buffer: 25 mM Tris-HCl, 100 mM KCl, 5 mM MgCl2, 1 mM DTT, pH: 7.5 Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Oct 1 RgGuinier 3.7 nm Dmax 15.3 nm VolumePorod 138 nm3