Dissecting NGF interactions with TrkA and p75 receptors by structural and functional studies of an anti-NGF neutralizing antibody.

Covaceuszach S, Cassetta A, Konarev PV, Gonfloni S, Rudolph R, Svergun DI, Lamba D, Cattaneo A
J Mol Biol 381(4):881-96 (2008 Sep 12)

PMID: 18635195 doi: 10.1016/j.jmb.2008.06.008

Published in SASBDB: 2015 Jul 7

SASDAS5 – ad11 Fab Sample: AD11 Fab dimer, 50 kDa Mus musculus protein Buffer: 50 mM Na-phosphate 1mM ethylenediaminetetraacetic aci, pH: 7 Experiment: SAXS data collected at EMBL X33, DORIS III, DESY on 2005 Oct 20 RgGuinier 2.6 nm Dmax 8.0 nm VolumePorod 95 nm3

SASDAT5 – NGF Sample: NGF dimer, 50 kDa Mus musculus protein Buffer: 10 mM Na-phosphate 150 mM NaCl, pH: 7.8 Experiment: SAXS data collected at EMBL X33, DORIS III, DESY on 2005 Oct 20 RgGuinier 3.1 nm Dmax 12.0 nm VolumePorod 102 nm3

SASDAU5 – ad11 Fab + NGF Sample: AD11 Fab dimer, 50 kDa Mus musculus protein NGF dimer, 50 kDa Mus musculus protein Buffer: 30 mM Na-phosphate 75 mM NaCl, pH: 7 Experiment: SAXS data collected at EMBL X33, DORIS III, DESY on 2005 Dec 20 RgGuinier 4.3 nm Dmax 16.0 nm VolumePorod 255 nm3