Solution structure of ectodomains of the insulin receptor family: the ectodomain of the type 1 insulin-like growth factor receptor displays asymmetry of ligand binding accompanied by limited conformational change.

Whitten AE, Smith BJ, Menting JG, Margetts MB, McKern NM, Lovrecz GO, Adams TE, Richards K, Bentley JD, Trewhella J, Ward CW, Lawrence MC
J Mol Biol 394(5):878-92 (2009 Dec 18)
PMID: 19835884
doi: 10.1016/j.jmb.2009.10.011 		Submitted to SASBDB: 2019 Nov 4
Published in SASBDB:

SASDHE2 – Type 1 insulin-like growth factor receptor ectodomains (IGF-1RΔβ)

Insulin-like growth factor 1 receptor experimental SAS data
BUNCH model
Sample: Insulin-like growth factor 1 receptor dimer, 202 kDa Homo sapiens protein
Buffer: 30 mM Tris, 140 mM NaCl, 0.02% w/v sodium azide,, pH: 7.5
Experiment: SAXS data collected at Bruker Nanostar, Australian Nuclear Science and Technology Organisation on 2008 Apr 22
RgGuinier 5.1 nm
Dmax 16.0 nm
VolumePorod 357 nm3

SASDHF2 – Insulin receptor ectodomains (IRΔβ)

Insulin receptor experimental SAS data
BUNCH model
Sample: Insulin receptor dimer, 203 kDa Homo sapiens protein
Buffer: 30 mM Tris, 140 mM NaCl, 0.02% w/v sodium azide,, pH: 7.5
Experiment: SAXS data collected at Bruker Nanostar, Australian Nuclear Science and Technology Organisation on 2008 Dec 7
RgGuinier 5.5 nm
Dmax 17.0 nm
VolumePorod 385 nm3