Search

  
Advanced search  

5 hits found for Badarau

SASDF45 – Leukocidin/Integrin alpha-M complex (LukGH-huCD11b-I) in the presence of a neutralizing antibody Fab fragment

Leukocidin GLeukocidin HLukGH neutralizing antibodyIntegrin alpha-M experimental SAS data
PYMOL model
Sample: Leukocidin G monomer, 36 kDa Staphylococcus aureus protein
Leukocidin H monomer, 38 kDa Staphylococcus aureus protein
LukGH neutralizing antibody monomer, 47 kDa Homo sapiens protein
Integrin alpha-M monomer, 22 kDa Homo sapiens protein
Buffer: 20 mM Hepes, 300 mM NaCl, 1 mM MgCl2, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2017 Sep 17
Molecular mechanism of leukocidin GH-integrin CD11b/CD18 recognition and species specificity. Proc Natl Acad Sci U S A (2019)
...Badarau A
RgGuinier 5.0 nm
Dmax 18.0 nm
VolumePorod 178 nm3

SASDF55 – Leukocidin (LukGH) from Staphylococcus aureus in complex with a neutralizing antibody

Leukocidin GLeukocidin HLukGH neutralizing antibody experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Leukocidin G monomer, 36 kDa Staphylococcus aureus protein
Leukocidin H monomer, 38 kDa Staphylococcus aureus protein
LukGH neutralizing antibody monomer, 47 kDa Homo sapiens protein
Buffer: 20 mM Hepes, 300 mM NaCl, 1 mM MgCl2, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2017 Sep 17
Molecular mechanism of leukocidin GH-integrin CD11b/CD18 recognition and species specificity. Proc Natl Acad Sci U S A (2019)
...Badarau A
RgGuinier 4.7 nm
Dmax 16.0 nm
VolumePorod 152 nm3

SASDZ46 – Engineered LysM-CHAP derivative of autolysin LytN (Fc-hel8-L1-3)

Fc-hel8-L1-3 experimental SAS data
Fc-hel8-L1-3 Kratky plot
Sample: Fc-hel8-L1-3 dimer, 109 kDa S.aureus protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH 7.0, pH: 7
Experiment: SAXS data collected at EMBL P12, PETRA III on 2025 Apr 6
SEC-SAXS data of Fc-hel8-L1-3
Adriana Badarau
RgGuinier 6.4 nm
Dmax 30.0 nm

SASDZ88 – Synthetic fusion protein comprising human IgG1 Fc, the CHAP domain of engineered Staphylococcus aureus LytN, and engineered Staphylococcus simulans lysostaphin (Fc-L2a-CHAP(alt)-LSN(HEK))

Fc-L2a-CHAP(alt)-LSN(HEK) experimental SAS data
Fc-L2a-CHAP(alt)-LSN(HEK) Kratky plot
Sample: Fc-L2a-CHAP(alt)-LSN(HEK) dimer, 156 kDa synthetic construct protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH 7.0, pH: 7
Experiment: SAXS data collected at EMBL P12, PETRA III on 2025 Apr 6
A chimeric, half-life extended lysin with a unique mode of action Frontiers in Microbiology 17 (2026)
...Badarau A
RgGuinier 8.9 nm
Dmax 40.0 nm

SASDZ98 – Engineered fusion of derivative of S.aureus LytN (CHAP domain) and derivative of S.simulans lysostaphin (Fc-L1-CHAP(opt)-LSN(HEK))

Fc-L1-CHAP(opt)-LSN(HEK) experimental SAS data
Fc-L1-CHAP(opt)-LSN(HEK) Kratky plot
Sample: Fc-L1-CHAP(opt)-LSN(HEK) dimer, 148 kDa synthetic construct protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH 7.0, pH: 7
Experiment: SAXS data collected at EMBL P12, PETRA III on 2025 Apr 6
A chimeric, half-life extended lysin with a unique mode of action Frontiers in Microbiology 17 (2026)
...Badarau A
RgGuinier 7.3 nm
Dmax 40.0 nm