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4 hits found for Bainbridge

SASDXE9 – poly(ADP-ribose)polymerase 1 (Af-PARP1) apo protein

Aspergillus fumigatus poly(ADP-ribose)polymerase 1 experimental SAS data
Aspergillus fumigatus poly(ADP-ribose)polymerase 1 Kratky plot
Sample: Aspergillus fumigatus poly(ADP-ribose)polymerase 1 monomer, 74 kDa Aspergillus fumigatus protein
Buffer: 20 mM HEPES, 150 mM NaCl, 2 mM TCEP, 2.5% (v/v) Glycerol, pH: 7.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Nov 14
The BRCT domain enhances DNA binding and catalytic efficiency of fungal PARPs. Nat Commun 17(1) (2026)
Bainbridge AG, Gianga TM, Hussain R, Parkin C, Longhurst AD, Helmstetter N, Farrer RA, Catania S, Siligardi G, Rack JGM
RgGuinier 4.4 nm
Dmax 13.7 nm
VolumePorod 131 nm3

SASDXF9 – poly(ADP-ribose)polymerase 1 (Af-PARP1) with N-terminal dBRCT domain truncation

Aspergillus fumigatus poly(ADP-ribosyl)polymerase 1 dBRCT experimental SAS data
Aspergillus fumigatus poly(ADP-ribosyl)polymerase 1 dBRCT Kratky plot
Sample: Aspergillus fumigatus poly(ADP-ribosyl)polymerase 1 dBRCT monomer, 58 kDa Aspergillus fumigatus protein
Buffer: 20 mM HEPES, 150 mM NaCl, 2 mM TCEP, 2.5% (v/v) Glycerol, pH: 7.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2025 Jul 28
The BRCT domain enhances DNA binding and catalytic efficiency of fungal PARPs. Nat Commun 17(1) (2026)
Bainbridge AG, Gianga TM, Hussain R, Parkin C, Longhurst AD, Helmstetter N, Farrer RA, Catania S, Siligardi G, Rack JGM
RgGuinier 3.2 nm
Dmax 10.9 nm
VolumePorod 111 nm3

SASDXG9 – poly(ADP-ribose)polymerase 1 (Af-PARP1) 5'P nicked DNA complex

Aspergillus fumigatus poly(ADP-ribose)polymerase 15'Phosphorylated nicked DNA damage mimetic experimental SAS data
Aspergillus fumigatus poly(ADP-ribose)polymerase 1 5'Phosphorylated nicked DNA damage mimetic Kratky plot
Sample: Aspergillus fumigatus poly(ADP-ribose)polymerase 1 monomer, 74 kDa Aspergillus fumigatus protein
5'Phosphorylated nicked DNA damage mimetic monomer, 14 kDa DNA
Buffer: 20 mM HEPES, 150 mM NaCl, 2 mM TCEP, 2.5% (v/v) Glycerol, pH: 7.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Nov 14
The BRCT domain enhances DNA binding and catalytic efficiency of fungal PARPs. Nat Commun 17(1) (2026)
Bainbridge AG, Gianga TM, Hussain R, Parkin C, Longhurst AD, Helmstetter N, Farrer RA, Catania S, Siligardi G, Rack JGM
RgGuinier 4.3 nm
Dmax 16.6 nm
VolumePorod 190 nm3

SASDXH9 – poly(ADP-ribose)polymerase 1 (Af-PARP1) with N-terminal dBRCT domain truncation:5'P nicked DNA complex

Aspergillus fumigatus poly(ADP-ribosyl)polymerase 1 dBRCT5'Phosphorylated nicked DNA damage mimetic experimental SAS data
Aspergillus fumigatus poly(ADP-ribosyl)polymerase 1 dBRCT 5'Phosphorylated nicked DNA damage mimetic Kratky plot
Sample: Aspergillus fumigatus poly(ADP-ribosyl)polymerase 1 dBRCT monomer, 58 kDa Aspergillus fumigatus protein
5'Phosphorylated nicked DNA damage mimetic monomer, 14 kDa DNA
Buffer: 20 mM HEPES, 150 mM NaCl, 2 mM TCEP, 2.5% (v/v) Glycerol, pH: 7.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Nov 14
The BRCT domain enhances DNA binding and catalytic efficiency of fungal PARPs. Nat Commun 17(1) (2026)
Bainbridge AG, Gianga TM, Hussain R, Parkin C, Longhurst AD, Helmstetter N, Farrer RA, Catania S, Siligardi G, Rack JGM
RgGuinier 3.5 nm
Dmax 11.4 nm
VolumePorod 151 nm3