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6 hits found for Bhatt

SASDYW2 – IgA1 dimer - Control

Human immunoglobulin IgA1 experimental SAS data
CUSTOM IN-HOUSE model
Sample: Human immunoglobulin IgA1 dimer, 320 kDa protein
Buffer: 8.2 mM Na2HPO4, 1.5 mM KH2PO4, 137 mM NaCl, 2.6 mM KCl (PBS), pH: 7.4
Experiment: SAXS data collected at BM29, ESRF on 2014 Sep 7
Atomistic scattering modelling of the solution structure of human dimeric IgA1 reveals a structural and mechanistic basis for IgA nephropathy. J Biol Chem :113156 (2026)
Bhatt JS, Yeo SC, Ireland SM, Ben-Younis A, Gor J, Molyneux K, Barratt J, Perkins SJ
RgGuinier 8.7 nm
Dmax 35.0 nm

SASDLX2 – Immunoglobulin G4 (IgG4) Deglycosylated

Immunoglobulin G subclass 4 experimental SAS data
CUSTOM IN-HOUSE model
Sample: Immunoglobulin G subclass 4 monomer, 145 kDa Homo sapiens protein
Buffer: 20 mM L-histidine, 138 mM NaCl, and 2.6 mM KCl buffer, pH: 6
Experiment: SAXS data collected at B21, Diamond Light Source on 2017 Oct 20
Using atomistic solution scattering modelling to elucidate the role of the Fc glycans in human IgG4. PLoS One 19(4):e0300964 (2024)
...Bhatt JS, Gor J, Dalby PA, Perkins SJ
RgGuinier 4.9 nm
Dmax 16.9 nm
VolumePorod 258 nm3

SASDYX2 – IgA1 dimer - Patient A

Human immunoglobulin IgA1 experimental SAS data
CUSTOM IN-HOUSE model
Sample: Human immunoglobulin IgA1 dimer, 320 kDa protein
Buffer: PBS buffer, 137 mM NaCl, 8.2 mM Na2HPO4, 2.6 mM KCl, 1.5 mM KH2PO4, pH: 7.4
Experiment: SAXS data collected at BM29, ESRF on 2014 Sep 7
Atomistic scattering modelling of the solution structure of human dimeric IgA1 reveals a structural and mechanistic basis for IgA nephropathy. J Biol Chem :113156 (2026)
Bhatt JS, Yeo SC, Ireland SM, Ben-Younis A, Gor J, Molyneux K, Barratt J, Perkins SJ
RgGuinier 8.6 nm
Dmax 35.0 nm

SASDLY2 – Immunoglobulin G4 (IgG4) Glycosylated

Immunoglobulin G subclass 4 experimental SAS data
CUSTOM IN-HOUSE model
Sample: Immunoglobulin G subclass 4 monomer, 145 kDa Homo sapiens protein
Buffer: 20 mM L-histidine, 138 mM NaCl, and 2.6 mM KCl buffer, pH: 6
Experiment: SAXS data collected at B21, Diamond Light Source on 2017 Oct 20
Using atomistic solution scattering modelling to elucidate the role of the Fc glycans in human IgG4. PLoS One 19(4):e0300964 (2024)
...Bhatt JS, Gor J, Dalby PA, Perkins SJ
RgGuinier 4.9 nm
Dmax 16.3 nm
VolumePorod 256 nm3

SASDYY2 – IgA1 dimer - Patient B

Human immunoglobulin IgA1 experimental SAS data
CUSTOM IN-HOUSE model
Sample: Human immunoglobulin IgA1 dimer, 320 kDa protein
Buffer: PBS buffer, 137 mM NaCl, 8.2 mM Na2HPO4, 2.6 mM KCl, 1.5 mM KH2PO4, pH: 7.4
Experiment: SAXS data collected at BM29, ESRF on 2014 Sep 7
Atomistic scattering modelling of the solution structure of human dimeric IgA1 reveals a structural and mechanistic basis for IgA nephropathy. J Biol Chem :113156 (2026)
Bhatt JS, Yeo SC, Ireland SM, Ben-Younis A, Gor J, Molyneux K, Barratt J, Perkins SJ
RgGuinier 8.4 nm
Dmax 35.0 nm

SASDYZ2 – IgA1 dimer - Patient C

Human immunoglobulin IgA1 experimental SAS data
CUSTOM IN-HOUSE model
Sample: Human immunoglobulin IgA1 dimer, 320 kDa protein
Buffer: PBS buffer, 137 mM NaCl, 8.2 mM Na2HPO4, 2.6 mM KCl, 1.5 mM KH2PO4, pH: 7.4
Experiment: SAXS data collected at BM29, ESRF on 2014 Sep 7
Atomistic scattering modelling of the solution structure of human dimeric IgA1 reveals a structural and mechanistic basis for IgA nephropathy. J Biol Chem :113156 (2026)
Bhatt JS, Yeo SC, Ireland SM, Ben-Younis A, Gor J, Molyneux K, Barratt J, Perkins SJ
RgGuinier 8.5 nm
Dmax 35.0 nm