Small Angle Scattering Biological Data Bank SASBDB


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7 hits found for Jahan

SASDFE6 – Sliding beta clamp

Beta sliding clamp experimental SAS data

Sample:	Beta sliding clamp dimer, 86 kDa Mycobacterium tuberculosis protein
Buffer:	50 mM Tris pH 8.0, 200 mM NaCl , 2 mM β-mercaptoethanol, pH: 8
Experiment:	SAXS data collected at BM29, ESRF on 2017 May 15

Regulation of futile ligation during early steps of BER in M. tuberculosis is carried out by a β-clamp-XthA-LigA tri-component complex International Journal of Biological Macromolecules (2022)
...Jahan F, Ramachandran R

R_g^Guinier	3.7	nm
D_max	10.3	nm
Volume^Porod	186	nm³

SASDFF6 – Probable exodeoxyribonuclease III protein XthA, sliding beta clamp complex

Beta sliding clampProbable exodeoxyribonuclease III protein XthA (Exonuclease III) (EXO III) (AP endonuclease VI) experimental SAS data

Sample:	Beta sliding clamp dimer, 86 kDa Mycobacterium tuberculosis protein Probable exodeoxyribonuclease III protein XthA (Exonuclease III) (EXO III) (AP endonuclease VI) monomer, 33 kDa Mycobacterium tuberculosis protein
Buffer:	50 mM Tris-HCl, 200 mM NaCl, 2 mM β-mercaptoethanol, pH: 8
Experiment:	SAXS data collected at BM29, ESRF on 2017 May 15

R_g^Guinier	3.5	nm
D_max	11.3	nm
Volume^Porod	98	nm³

SASDFG6 – Probable exodeoxyribonuclease III protein XthA, sliding beta clamp, DNA ligase-A tricomplex

Beta sliding clampProbable exodeoxyribonuclease III protein XthADNA ligase A experimental SAS data

Sample:	Beta sliding clamp dimer, 86 kDa Mycobacterium tuberculosis protein Probable exodeoxyribonuclease III protein XthA monomer, 31 kDa Mycobacterium tuberculosis protein DNA ligase A monomer, 76 kDa Mycobacterium tuberculosis protein
Buffer:	50 mM Tris-HCl, 200 mM NaCl, 2 mM β-mercaptoethanol, pH: 8
Experiment:	SAXS data collected at BM29, ESRF on 2017 May 17

R_g^Guinier	5.8	nm
D_max	25.3	nm
Volume^Porod	501	nm³

SASDFH6 – Probable exodeoxyribonuclease III protein XthA, sliding beta clamp, DNA ligase-A tricomplex in the presence of DNA substrate

Probable exodeoxyribonuclease III protein XthADNA ligase ABeta sliding clampDNA ligase A nicked DNA substrate experimental SAS data

Sample:	Probable exodeoxyribonuclease III protein XthA monomer, 31 kDa Mycobacterium tuberculosis protein DNA ligase A monomer, 76 kDa Mycobacterium tuberculosis protein Beta sliding clamp dimer, 86 kDa Mycobacterium tuberculosis protein DNA ligase A nicked DNA substrate dimer, 16 kDa DNA
Buffer:	50 mM Tris pH 8.0, 200 mM NaCl , 2 mM β-mercaptoethanol, pH: 8
Experiment:	SAXS data collected at BM29, ESRF on 2017 May 17

R_g^Guinier	5.8	nm
D_max	19.1	nm
Volume^Porod	496	nm³

SASDKP7 – Probable transcriptional regulatory protein Lrp/AsnC protein Rv2324

Probable transcriptional regulatory protein (Probably AsnC-family) experimental SAS data

Sample:	Probable transcriptional regulatory protein (Probably AsnC-family) dimer, 36 kDa Mycobacterium tuberculosis (strain … protein
Buffer:	20 mM Tris, 150 mM NaCl, 2 mM EDTA, pH: 7.5
Experiment:	SAXS data collected at Anton Paar SAXSpace, CSIR-Central Drug Research Institute on 2019 Mar 1

Mycobacterium tuberculosis Rv2324 is a multifunctional feast/famine regulatory protein involved in growth, DNA replication and damage control. Int J Biol Macromol 252:126459 (2023)
...Jahan F, Krishnan MY, Ramachandran R

R_g^Guinier	2.7	nm
D_max	11.6	nm
Volume^Porod	156	nm³

SASDKQ7 – Probable transcriptional regulatory protein Lrp/AsnC protein Rv2324 in the presence of methionine

Sample:	Probable transcriptional regulatory protein (Probably AsnC-family) octamer, 143 kDa Mycobacterium tuberculosis (strain … protein
Buffer:	20 mM Tris, 150 mM NaCl, 2 mM EDTA, 2 mM methionine, pH: 7.5
Experiment:	SAXS data collected at Anton Paar SAXSpace, CSIR-Central Drug Research Institute on 2019 Dec 5

R_g^Guinier	4.0	nm
D_max	13.8	nm
Volume^Porod	246	nm³

SASDTT8 – UvrB (UvrABC system protein B)

UvrABC system protein B experimental SAS data

Sample:	UvrABC system protein B dimer, 156 kDa Mycobacterium tuberculosis (strain … protein
Buffer:	50 mM Tris pH-8, 200 mM NaCl, 2% glycerol, pH:
Experiment:	SAXS data collected at Anton Paar SAXSpace, CSIR-Central Drug Research Institute on 2023 Jun 6

Inhibition of Mycobacterium tuberculosis UvrB by small molecules: Potent NER disruption and structural insights into dimer conformation. Int J Biol Macromol :147338 (2025)
Jahan F, Anand S, Kumar S, Pandey G, Siddiqi MI, Krishnan MY, Ramachandran R

R_g^Guinier	6.7	nm
D_max	17.5	nm
Volume^Porod	120	nm³