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4 hits found for Lauren Anderson

SASDZS5 – Frozen human Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 DH/PH tandem (P-Rex2 DH/PH ) with sucrose as cryoprotectant

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 DH/PH tandem experimental SAS data
BILBOMD model
Sample: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 DH/PH tandem monomer, 44 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 200 mM NaCl, 2 mM DTT, 1% glycerol, pH: 7
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2026 Feb 17
Freezing the P-Rex2 DH/PH tandem
Lauren Anderson
RgGuinier 2.6 nm
Dmax 8.4 nm
VolumePorod 48 nm3

SASDZT5 – Frozen human P-Rex2 DH/PH (Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein) without cryoprotectant

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 DH/PH tandem experimental SAS data
BILBOMD model
Sample: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 DH/PH tandem monomer, 44 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 200 mM NaCl, 2 mM DTT, 1% glycerol, pH: 7
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2026 Feb 17
Freezing the P-Rex2 DH/PH tandem
Lauren Anderson
RgGuinier 2.6 nm
Dmax 8.5 nm
VolumePorod 55 nm3

SASDZU5 – Human Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein DH/PH domain and DEP1 module (P-Rex2 DH/PH-DEP1)

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 DH/PH-DEP1 experimental SAS data
BILBOMD model
Sample: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 DH/PH-DEP1 monomer, 55 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 200 mM NaCl, 2 mM DTT, 1% glycerol, pH: 7
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2025 Jun 10
The Rho guanine-nucleotide exchange factor P-Rex2 exhibits structural and regulatory features distinct from the related RhoGEF P-Rex1 Journal of Biological Chemistry 302(7):113229 (2026)
Anderson L, Marde R, Muma G, Nayak V, Phan C, Li S, Cash J
RgGuinier 2.9 nm
Dmax 10.5 nm
VolumePorod 77 nm3

SASDZV5 – Human Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger protein 2 DH/PH domain tandem (P-Rex2 DH/PH)

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 DH/PH tandem experimental SAS data
BILBOMD model
Sample: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 DH/PH tandem monomer, 44 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 200 mM NaCl, 2 mM DTT, 1% glycerol, pH: 7
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2025 Jun 10
The Rho guanine-nucleotide exchange factor P-Rex2 exhibits structural and regulatory features distinct from the related RhoGEF P-Rex1 Journal of Biological Chemistry 302(7):113229 (2026)
Anderson L, Marde R, Muma G, Nayak V, Phan C, Li S, Cash J
RgGuinier 2.6 nm
Dmax 8.4 nm
VolumePorod 52 nm3