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8 hits found for Tomas Brom

SASDSE7 – Human CDAN1-interacting nuclease 1 (CDIN1): analysis of SEC peak

CDAN1-interacting nuclease 1 experimental SAS data
ALPHAFOLD model
Sample: CDAN1-interacting nuclease 1 dimer, 67 kDa Homo sapiens protein
Buffer: 20 mM Tris HCl, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at Anton Paar SAXSpoint 2.0, Institute of Biotechnology, Czech Academy of Sciences/Centre of Molecular Structure on 2021 Sep 2
Structural insights into inherited anemia CDA-I: disease-associated mutations disrupt Codanin1-CDIN1 complex
Tomas Brom
RgGuinier 3.0 nm
Dmax 8.2 nm
VolumePorod 84 nm3

SASDSF7 – Human Codanin1 (C-terminus): analysis of second monomeric SEC peak

Codanin-1 experimental SAS data
ALPHAFOLD model
Sample: Codanin-1 monomer, 25 kDa Homo sapiens protein
Buffer: 20 mM Tris HCl, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at Anton Paar SAXSpoint 2.0, Institute of Biotechnology, Czech Academy of Sciences/Centre of Molecular Structure on 2022 Mar 5
Structural insights into inherited anemia CDA-I: disease-associated mutations disrupt Codanin1-CDIN1 complex
Tomas Brom
RgGuinier 2.7 nm
Dmax 7.5 nm
VolumePorod 54 nm3

SASDSG7 – Human Codanin1 (C-terminus): analysis of first oligomeric SEC peak

Codanin-1 experimental SAS data
ALPHAFOLD model
Sample: Codanin-1 monomer, 25 kDa Homo sapiens protein
Buffer: 20 mM Tris HCl, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at Anton Paar SAXSpoint 2.0, Institute of Biotechnology, Czech Academy of Sciences/Centre of Molecular Structure on 2022 Mar 5
Structural insights into inherited anemia CDA-I: disease-associated mutations disrupt Codanin1-CDIN1 complex
Tomas Brom
RgGuinier 4.1 nm
Dmax 10.7 nm
VolumePorod 220 nm3

SASDVJ4 – Complex of CDAN1-interacting nuclease 1 and Codanin1 C-terminal domain (frames 712 - 720)

Codanin-1CDAN1-interacting nuclease 1 experimental SAS data
ALPHAFOLD model
Sample: Codanin-1 monomer, 25 kDa Homo sapiens protein
CDAN1-interacting nuclease 1 monomer, 33 kDa Homo sapiens protein
Buffer: 20 mM Tris HCl, 150 mM NaCl, 5% glycerol, pH: 8
Experiment: SAXS data collected at EMBL P12, PETRA III on 2023 Sep 29
Anemia-associated mutations disrupt the CDIN1-Codanin1 complex in inherited congenital dyserythropoietic anemia I (CDA-I) disease. FEBS J (2026)
...Brom T, Nečasová I, Janovič T, Veverka P, Verma N, Uhrík L, Hernychova L, Hofr C
RgGuinier 3.0 nm
Dmax 10.6 nm
VolumePorod 102 nm3

SASDV49 – Human Codanin1 C-terminal domain (frames 842 - 851)

Codanin-1 experimental SAS data
ALPHAFOLD model
Sample: Codanin-1 monomer, 25 kDa Homo sapiens protein
Buffer: 20 mM Tris HCl, 150 mM NaCl, 5% glycerol, pH: 8
Experiment: SAXS data collected at EMBL P12, PETRA III on 2023 Sep 29
Anemia-associated mutations disrupt the CDIN1-Codanin1 complex in inherited congenital dyserythropoietic anemia I (CDA-I) disease. FEBS J (2026)
...Brom T, Nečasová I, Janovič T, Veverka P, Verma N, Uhrík L, Hernychova L, Hofr C
RgGuinier 2.4 nm
Dmax 7.4 nm
VolumePorod 46 nm3

SASDV39 – Human CDAN1-interacting nuclease 1 (frames 692 - 701)

CDAN1-interacting nuclease 1 experimental SAS data
ALPHAFOLD model
Sample: CDAN1-interacting nuclease 1 monomer, 33 kDa Homo sapiens protein
Buffer: 20 mM Tris HCl, 150 mM NaCl, 5% glycerol, pH: 8
Experiment: SAXS data collected at EMBL P12, PETRA III on 2023 Sep 29
Anemia-associated mutations disrupt the CDIN1-Codanin1 complex in inherited congenital dyserythropoietic anemia I (CDA-I) disease. FEBS J (2026)
...Brom T, Nečasová I, Janovič T, Veverka P, Verma N, Uhrík L, Hernychova L, Hofr C
RgGuinier 2.8 nm
Dmax 8.9 nm
VolumePorod 104 nm3

SASDVG4 – Human CDAN1-interacting nuclease 1 (frames 717 - 723)

CDAN1-interacting nuclease 1 experimental SAS data
ALPHAFOLD model
Sample: CDAN1-interacting nuclease 1 dimer, 67 kDa Homo sapiens protein
Buffer: 20 mM Tris HCl, 150 mM NaCl, 5% glycerol, pH: 8
Experiment: SAXS data collected at EMBL P12, PETRA III on 2023 Sep 29
Anemia-associated mutations disrupt the CDIN1-Codanin1 complex in inherited congenital dyserythropoietic anemia I (CDA-I) disease. FEBS J (2026)
...Brom T, Nečasová I, Janovič T, Veverka P, Verma N, Uhrík L, Hernychova L, Hofr C
RgGuinier 2.8 nm
Dmax 9.9 nm
VolumePorod 85 nm3

SASDVH4 – Human Codanin1 C-terminal domain (frames 779 - 791)

Codanin-1 experimental SAS data
ALPHAFOLD model
Sample: Codanin-1 monomer, 25 kDa Homo sapiens protein
Buffer: 20 mM Tris HCl, 150 mM NaCl, 5% glycerol, pH: 8
Experiment: SAXS data collected at EMBL P12, PETRA III on 2023 Sep 29
Anemia-associated mutations disrupt the CDIN1-Codanin1 complex in inherited congenital dyserythropoietic anemia I (CDA-I) disease. FEBS J (2026)
...Brom T, Nečasová I, Janovič T, Veverka P, Verma N, Uhrík L, Hernychova L, Hofr C
RgGuinier 2.5 nm
Dmax 9.3 nm
VolumePorod 51 nm3