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7 hits found for Estrogen receptor alpha

SASDEE2 – ...estrogen receptor alpha

Estrogen receptor experimental SAS data
CUSTOM IN-HOUSE model
Sample: Estrogen receptor monomer, 20 kDa Homo sapiens protein
Buffer: 20 mM sodium phosphate, 50 mM NaCl, 0.05 mM TCEP, pH: 7.4
Experiment: SAXS data collected at 16-ID (LiX), National Synchrotron Light Source II (NSLS-II) on 2017 Jun 12
...Estrogen Receptor Transactivation Domain. Structure 27(2):229-240.e4 (2019)
Peng Y, Cao S, Kiselar J, Xiao X, Du Z, Hsieh A, Ko S, Chen Y, Agrawal P, Zheng W, Shi W, Jiang W, Yang L, Chance MR, Surewicz WK, Buck M, Yang S
RgGuinier 3.0 nm
Dmax 10.0 nm

SASDSK2 – ...estrogen receptor alpha, N-terminal domain (NTD) at pH 7.4

Estrogen receptor experimental SAS data
Estrogen receptor Kratky plot
Sample: Estrogen receptor monomer, 20 kDa Homo sapiens protein
Buffer: 20 mM sodium phosphate, 150 mM NaCl, 0.5 mM EDTA, 0.1 mM PMSF, pH: 7.4
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2019 Jul 21
The sequence–structure–function relationship of intrinsic ERα disorder Nature (2025)
Du Z, Wang H, Luo S, Yun Z, Wu C, Yang W, Buck M, Zheng W, Hansen A, Kao H, Yang S
RgGuinier 3.2 nm
Dmax 14.0 nm
VolumePorod 47 nm3

SASDVC5 – ...estrogen receptor alpha (pSer118), N-terminal domain (NTD) at pH 7.4

Estrogen receptor experimental SAS data
Estrogen receptor Kratky plot
Sample: Estrogen receptor monomer, 20 kDa Homo sapiens protein
Buffer: 20 mM sodium phosphate, 50 mM NaCl, 0.05 mM TCEP, pH: 7.4
Experiment: SAXS data collected at 16-ID (LiX), National Synchrotron Light Source II (NSLS-II) on 2024 Jul 17
The sequence–structure–function relationship of intrinsic ERα disorder Nature (2025)
Du Z, Wang H, Luo S, Yun Z, Wu C, Yang W, Buck M, Zheng W, Hansen A, Kao H, Yang S
RgGuinier 3.6 nm
Dmax 16.0 nm
VolumePorod 70 nm3

SASDSE5 – ...estrogen receptor alpha (S118A), N-terminal domain (NTD) at pH 7.4

Estrogen receptor (mutant S118A) experimental SAS data
Estrogen receptor (mutant S118A) Kratky plot
Sample: Estrogen receptor (mutant S118A) monomer, 20 kDa Homo sapiens protein
Buffer: 20 mM sodium phosphate, 150 mM NaCl, 0.5 mM EDTA, 0.1 mM PMSF, pH: 7.4
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2019 Jul 21
The sequence–structure–function relationship of intrinsic ERα disorder Nature (2025)
Du Z, Wang H, Luo S, Yun Z, Wu C, Yang W, Buck M, Zheng W, Hansen A, Kao H, Yang S
RgGuinier 3.2 nm
Dmax 15.0 nm
VolumePorod 71 nm3

SASDSF5 – ...estrogen receptor alpha (S118D), N-terminal domain (NTD) at pH 7.4

Estrogen receptor (mutant S118D) experimental SAS data
Estrogen receptor (mutant S118D) Kratky plot
Sample: Estrogen receptor (mutant S118D) monomer, 20 kDa Homo sapiens protein
Buffer: 20 mM sodium phosphate, 150 mM NaCl, 0.5 mM EDTA, 0.1 mM PMSF, pH: 7.4
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2019 Jul 21
The sequence–structure–function relationship of intrinsic ERα disorder Nature (2025)
Du Z, Wang H, Luo S, Yun Z, Wu C, Yang W, Buck M, Zheng W, Hansen A, Kao H, Yang S
RgGuinier 3.5 nm
Dmax 16.0 nm
VolumePorod 62 nm3

SASDWC7 – ...estrogen receptor alpha ligand binding domain (LBD) at pH 7.5

Estrogen receptor alpha experimental SAS data
DAMMIF model
Sample: Estrogen receptor alpha dimer, 55 kDa Homo sapiens protein
Buffer: 20 mM Tris-HCl pH 7.5, 150 mM NaCl, 5% glycerol, 2 mM TCEP, pH: 7.5
Experiment: SAXS data collected at BioSAXS, Australian Synchrotron on 2024 Nov 9
A ternary switch model governing ERα ligand binding domain conformation. Nat Commun 16(1):10363 (2025)
McDougal DP, Pederick JL, Novick SJ, Jovcevski B, Warrender AK, Pascal BD, Griffin PR, Bruning JB
RgGuinier 2.4 nm
Dmax 7.4 nm
VolumePorod 74 nm3

SASDWD7 – ...estrogen receptor alpha ligand binding domain (LBD) at pH 7.5

Estrogen receptor alpha experimental SAS data
DAMMIF model
Sample: Estrogen receptor alpha dimer, 57 kDa Melanotaenia fluviatilis protein
Buffer: 20 mM Tris-HCl pH 7.5, 150 mM NaCl, 5% glycerol, 2 mM TCEP, pH: 7.5
Experiment: SAXS data collected at BioSAXS, Australian Synchrotron on 2024 Nov 9
A ternary switch model governing ERα ligand binding domain conformation. Nat Commun 16(1):10363 (2025)
McDougal DP, Pederick JL, Novick SJ, Jovcevski B, Warrender AK, Pascal BD, Griffin PR, Bruning JB
RgGuinier 2.5 nm
Dmax 9.2 nm
VolumePorod 72 nm3