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2 hits found for Mitogen-activated protein kinase 14

SASDRC6 – ...mitogen-activated protein kinase kinase 6 (MKK6GRA) bound to mitogen-activated protein kinase 14 (p38α) with ADP-AlF4

Mitogen-activated protein kinase 14Dual specificity mitogen-activated protein kinase kinase 6Adenosine 5'-Diphosphate Tetrafluoroaluminate experimental SAS data
Mitogen-activated protein kinase 14 Dual specificity mitogen-activated protein kinase kinase 6 Adenosine 5'-Diphosphate Tetrafluoroaluminate Kratky plot
Sample: Mitogen-activated protein kinase 14 monomer, 40 kDa Homo sapiens protein
...mitogen-activated protein kinase kinase 6 monomer, 42 kDa synthetic construct protein
Adenosine 5'-Diphosphate Tetrafluoroaluminate monomer, 1 kDa
Buffer: 50 mM HEPES, 200 mM NaCl, 10 mM MgCl2, 5 % glycerol, 0.5 mM TCEP, pH: 7.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2019 May 15
Architecture of the MKK6-p38α complex defines the basis of MAPK specificity and activation Science 381(6663):1217-1225 (2023)
Juyoux P, Galdadas I, Gobbo D, von Velsen J, Pelosse M, Tully M, Vadas O, Gervasio F, Pellegrini E, Bowler M
RgGuinier 3.2 nm
Dmax 12.1 nm
VolumePorod 113 nm3

SASDRD6 – ...mitogen-activated protein kinase kinase 6 (MKK6GRA) bound to mitogen-activated protein kinase 14 (p38α) with AMP-PCP

Mitogen-activated protein kinase 14Dual specificity mitogen-activated protein kinase kinase 65′‐adenylyl methylenediphosphonate experimental SAS data
Mitogen-activated protein kinase 14 Dual specificity mitogen-activated protein kinase kinase 6 5′‐adenylyl methylenediphosphonate Kratky plot
Sample: Mitogen-activated protein kinase 14 monomer, 40 kDa Homo sapiens protein
...mitogen-activated protein kinase kinase 6 monomer, 42 kDa synthetic construct protein
5′‐adenylyl methylenediphosphonate monomer, 1 kDa
Buffer: 50 mM HEPES, 200 mM NaCl, 10 mM MgCl2, 5 % glycerol, 0.5 mM TCEP, pH: 7.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2019 May 15
Architecture of the MKK6-p38α complex defines the basis of MAPK specificity and activation Science 381(6663):1217-1225 (2023)
Juyoux P, Galdadas I, Gobbo D, von Velsen J, Pelosse M, Tully M, Vadas O, Gervasio F, Pellegrini E, Bowler M
RgGuinier 4.2 nm
Dmax 14.0 nm
VolumePorod 116 nm3