SASBDB entries for UniProt ID: P00736

SASDBZ7 – Complement factor 1s in complex with Complement factor 1r

UniProt ID: P00736 (18-705) Complement C1r subcomponent

UniProt ID: P09871 (16-688) Complement C1s subcomponent

Complement C1r subcomponentComplement C1s subcomponent experimental SAS data
CORAL model
Sample: Complement C1r subcomponent dimer, 156 kDa Homo sapiens protein
Complement C1s subcomponent dimer, 150 kDa Homo sapiens protein
Buffer: 50 mM TrisHCl, 145 mM NaCl, 3 mM CaCl2, pH: 7.4
Experiment: SAXS data collected at BM29, ESRF on 2014 Dec 8
Structure and activation of C1, the complex initiating the classical pathway of the complement cascade. Proc Natl Acad Sci U S A 114(5):986-991 (2017)
Mortensen SA, Sander B, Jensen RK, Pedersen JS, Golas MM, Jensenius JC, Hansen AG, Thiel S, Andersen GR
RgGuinier 11.6 nm

SASDB38 – Inactivated complement factor 1 (C1)

UniProt ID: P02747 (23-245) Complement C1q subcomponent subunit C

UniProt ID: P02746 (28-253) Complement C1q subcomponent subunit B

UniProt ID: P02745 (23-245) Complement C1q subcomponent subunit A

UniProt ID: P00736 (18-705) Complement C1r subcomponent

UniProt ID: P09871 (16-688) Complement C1s subcomponent

Complement C1q subcomponent subunit CComplement C1q subcomponent subunit BComplement C1q subcomponent subunit AComplement C1r subcomponentComplement C1s subcomponent experimental SAS data
CORAL model
Sample: Complement C1q subcomponent subunit C hexamer, 142 kDa Homo sapiens protein
Complement C1q subcomponent subunit B hexamer, 142 kDa Homo sapiens protein
Complement C1q subcomponent subunit A hexamer, 142 kDa Homo sapiens protein
Complement C1r subcomponent dimer, 156 kDa Homo sapiens protein
Complement C1s subcomponent dimer, 150 kDa Homo sapiens protein
Buffer: 50 mM EPPS, 145 mM NaCl, 3 mM CaCl2, pH: 8.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2015 Aug 16
Structure and activation of C1, the complex initiating the classical pathway of the complement cascade. Proc Natl Acad Sci U S A 114(5):986-991 (2017)
Mortensen SA, Sander B, Jensen RK, Pedersen JS, Golas MM, Jensenius JC, Hansen AG, Thiel S, Andersen GR
RgGuinier 11.5 nm
Dmax 36.6 nm

SASDKV7 – CCP2-SP domains of the complement C1r subcomponent

UniProt ID: P00736 (375-705) Complement C1r subcomponent

Complement C1r subcomponent experimental SAS data
PYMOL model
Sample: Complement C1r subcomponent monomer, 38 kDa Homo sapiens protein
Buffer: 10 mM HEPES, 140 mM NaCl, pH: 7.3
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2019 Sep 24
A structural basis for inhibition of the complement initiator protease C1r by Lyme disease spirochetes
Ryan Garrigues
RgGuinier 2.4 nm
Dmax 7.9 nm
VolumePorod 63 nm3

SASDKX7 – CCP2-SP domains of the complement C1r subcomponent bound to the complement inhibitory domain of the Borrelia burgdorferi fibronectin-binding protein BBK32

UniProt ID: O50835 (206-348) Fibronectin-binding protein BBK32

UniProt ID: P00736 (376-705) Complement C1r subcomponent

Fibronectin-binding protein BBK32Complement C1r subcomponent experimental SAS data
PYMOL model
Sample: Fibronectin-binding protein BBK32 monomer, 17 kDa Borrelia burgdorferi (strain … protein
Complement C1r subcomponent monomer, 38 kDa Homo sapiens protein
Buffer: 10 mM HEPES, 140 mM NaCl, pH: 7.3
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2019 Sep 24
A structural basis for inhibition of the complement initiator protease C1r by Lyme disease spirochetes
Ryan Garrigues
RgGuinier 2.8 nm
Dmax 8.6 nm
VolumePorod 75 nm3